Navigation Links
How stem cells are regulated

Researchers from Biotech Research & Innovation Centre (BRIC) at University of Copenhagen have identified a new group of proteins that regulate the function of stem cells. The results are published in the new issue of Cell.

All living organisms, including human beings, consist of a number of specialised cell types that all originate from the same type of primal cell; the embryonic stem cell. Stem cells can develop into any type of cell through a carefully regulated process referred to as cellular differentiation. During differentiation, specific genes are switched on while other genes are switched off. The genes that are activated during differentiation determine which type of cell the stem cell will become. The result is that cells in a particular organ, e.g. a liver, only express genes specific to that organ.

Director of BRIC, Professor Kristian Helin led the research team consisting of Jesper Christensen, Karl Agger and Paul Cloos. Last year, the same research group published an article in Nature on how a group of Jumonji proteins regulate the growth of cancer cells and are involved in the development of specific cancer types.

BRIC’s new results show that a different subgroup of Jumonji proteins is essential for cellular differentiation. The Jumonji enzymes can turn off, or inactivate, particular genes that play an important part in embryogenesis. The conclusions are based on studies of the nematode (roundworm) C. elegans and studies of mouse embryonic stem cells. The C. elegans studies were carried out in collaboration with another of BRIC’s research groups, led by Associate Professor Lisa Salcini.

The BRIC researchers are currently developing inhibitors to the Jumonji proteins. Their aim is to use these inhibitors to treat cancer patients with increased levels of the Jumonji proteins.
'"/>

Source:University of Copenhagen


Page: 1

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. Spleen may be source of versatile stem cells
3. Researchers discover way to make cells in the eye sensitive to light
4. Priming embryonic stem cells to fulfill their promise
5. Lack of enzyme turns fat cells into fat burners
6. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
7. Elusive HIV shape change revealed; Key clue to how virus infects cells
8. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
9. Enzyme allows B cells to resist death, leading to leukemia
10. Scientists rid stem cell culture of key animal cells
11. Genetically modified natural killer immune cells attack, kill leukemia cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: How stem cells are regulated

(Date:6/17/2013)... An international team led by scientists at The Scripps ... Albert Einstein College of Medicine of Yeshiva University has ... the tuberculosis (TB) bacterium in two different ways. , ... of the major global health crises of our timethe ... Peter G. Schultz, the Scripps Family Chair Professor of ...
(Date:6/17/2013)... understand the concept of improving original foundations with more ... the University of Pittsburgh,s Kenneth P. Dietrich School of ... that could make drug delivery, gas storage, and gas ... findings were reported in the latest issue of the ... JACS ). , The recent work builds upon Pitt ...
(Date:6/17/2013)... Kansas State University research associate has received a prestigious ... to prevent the spread of malaria. , Bart Bryant, ... of Health,s National Research Service Award Individual Postdoctoral Fellowship, ... seventh Kansas State University researcher to receive the award ... hold such an award. , Bryant, a university doctoral ...
Breaking Biology News(10 mins):New compound excels at killing persistent and drug-resistant tuberculosis 2New compound excels at killing persistent and drug-resistant tuberculosis 3New compound excels at killing persistent and drug-resistant tuberculosis 4'Chemical architects' build materials with potential applications in drug delivery and gas storage 2NIH fellowship helps researcher fight malaria, understand mosquito immunity 2
... Detects Faces in Motion, Matches with Watch-list ... Lithuania, March 9 Neurotechnology, a provider ... the availability of VeriLook Surveillance SDK, a ... using live video streams from high-resolution digital ...
... Va., March 10 CEL-SCI Corporation (NYSE Alternext US: ... launch a new manufacturing process that could allow drugs ... maintain their potency and thereby potentially also their shelf ... by CEL-SCI may also significantly accelerate the time to ...
... March 19 during 12 p.m. Advertising Research Foundation ... (R), a revolutionary media research firm, recently conducted ... Foundation (ARF) conference and provided attendees with same-day ... comprise impactful presentations. Results of the study, which ...
Cached Biology News:VeriLook Surveillance SDK Provides Real-Time Face Identification Using Video Surveillance Cameras 2VeriLook Surveillance SDK Provides Real-Time Face Identification Using Video Surveillance Cameras 3CEL-SCI Corporation to Launch Aseptic Filling for Stem Cell Produced Therapies and Other Biological Products 2CEL-SCI Corporation to Launch Aseptic Filling for Stem Cell Produced Therapies and Other Biological Products 3CEL-SCI Corporation to Launch Aseptic Filling for Stem Cell Produced Therapies and Other Biological Products 4Innerscope Research(R) Uses Same-Day Results From Biometric Study to Identify Key Themes, Styles Behind Effective, Engaging Speaker Presentations 2
(Date:6/18/2013)... June 18, 2013 Kitware , ... announces a new Fast-Track award from the U.S. Department ... environment (IDAE) for the nuclear power industry. , Construction ... more than 30 years, but the United States’ nuclear ... gains in power plant utilization through improved refueling, maintenance, ...
(Date:6/17/2013)... Belvoir, VA (PRWEB) June 17, 2013 ... annual Basic Research Technical Review at the Waterford in ... More than 300 grant awardees will present technical details ... Technical sessions will cover a broad range of counter ... (2) Cognitive, Information and Network Science; (3) Science for ...
(Date:6/17/2013)... (PRWEB) June 17, 2013 With the huge ... launch of the Chief Medical Officer Summit for Emerging Life ... will take place in San Francisco on November 4-5, 2013 ... the first time, West Coast Chief Medical Officers at biotechs ... Elizabeth Stoner, Managing Director of MPM Capital. Valerie Bowling, Executive ...
(Date:6/17/2013)... June 17, 2013 ... announced the addition of the "North ... Formulations [Liposomes, Microspheres, & Nanoparticles], Devices [Disposables ... Free & Auto Injectors] & Therapeutics- Forecasts ... ,      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ...
Breaking Biology Technology:Kitware to Develop an Open-Source HPC Design-Analysis Environment for Nuclear Energy Research 2Invitation to Register: Annual Defense Threat Reduction Agency Basic Research Technical Review 2Chief Medical Officer Summit for Biotechs Goes West 2Chief Medical Officer Summit for Biotechs Goes West 3North America Injectable Drug Delivery Market - by Formulations, Devices & Therapeutics- Forecasts to 2017 2North America Injectable Drug Delivery Market - by Formulations, Devices & Therapeutics- Forecasts to 2017 3
... 2010 (BRONX, NY) By constructing a microscope ... cells, researchers at Albert Einstein College of Medicine ... that occur during one of the most important "trips" ... Ribonucleic acid (RNA) molecules from the nucleus into the ...
... Therapies, Inc., (VTI) is pleased to announce that ... in Riyadh, Kingdom of Saudi Arabia (K.S.A.) in the further ... L i VER Failure) clinical trial to the ... therapy product, ELAD®, can prevent deterioration of liver function and ...
... BASKING RIDGE, N.J., Sept. 16 Regado Biosciences, a ... with active control agents, announced that David J. Mazzo, ... UBS Global Life Sciences Conference.  Dr. Mazzo,s presentation will ... York City on Wednesday, September 22, 2010 at 8:00 ...
Cached Biology Technology:Nature study shows how molecules escape from the nucleus 2Nature study shows how molecules escape from the nucleus 3Vital Therapies Expands SILVER Trial to Saudi Arabia 2Vital Therapies Expands SILVER Trial to Saudi Arabia 3Vital Therapies Expands SILVER Trial to Saudi Arabia 4Regado Biosciences to Present at the UBS Global Life Sciences Conference on September 22, 2010 in New York City 2Regado Biosciences to Present at the UBS Global Life Sciences Conference on September 22, 2010 in New York City 3
ANTI L-DOPA...
The Light Diagnostics Calicivirus Genotype 1&2 Typing OligoDetect assay is applicable for the qualitative detection of calicivirus RNA generated by an in-house validated in vitro nucleic acid amplifi...
Recombinant Rat CINC-2 alpha, CF...
sodium channel, nonvoltage-gated 1 alpha,...
Biology Products: