Navigation Links
How stem cells are regulated

Researchers from Biotech Research & Innovation Centre (BRIC) at University of Copenhagen have identified a new group of proteins that regulate the function of stem cells. The results are published in the new issue of Cell.

All living organisms, including human beings, consist of a number of specialised cell types that all originate from the same type of primal cell; the embryonic stem cell. Stem cells can develop into any type of cell through a carefully regulated process referred to as cellular differentiation. During differentiation, specific genes are switched on while other genes are switched off. The genes that are activated during differentiation determine which type of cell the stem cell will become. The result is that cells in a particular organ, e.g. a liver, only express genes specific to that organ.

Director of BRIC, Professor Kristian Helin led the research team consisting of Jesper Christensen, Karl Agger and Paul Cloos. Last year, the same research group published an article in Nature on how a group of Jumonji proteins regulate the growth of cancer cells and are involved in the development of specific cancer types.

BRIC’s new results show that a different subgroup of Jumonji proteins is essential for cellular differentiation. The Jumonji enzymes can turn off, or inactivate, particular genes that play an important part in embryogenesis. The conclusions are based on studies of the nematode (roundworm) C. elegans and studies of mouse embryonic stem cells. The C. elegans studies were carried out in collaboration with another of BRIC’s research groups, led by Associate Professor Lisa Salcini.

The BRIC researchers are currently developing inhibitors to the Jumonji proteins. Their aim is to use these inhibitors to treat cancer patients with increased levels of the Jumonji proteins.
'"/>

Source:University of Copenhagen


Page: 1

Related biology news :

1. Wisconsin scientists grow critical nerve cells
2. Spleen may be source of versatile stem cells
3. Researchers discover way to make cells in the eye sensitive to light
4. Priming embryonic stem cells to fulfill their promise
5. Lack of enzyme turns fat cells into fat burners
6. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
7. Elusive HIV shape change revealed; Key clue to how virus infects cells
8. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
9. Enzyme allows B cells to resist death, leading to leukemia
10. Scientists rid stem cell culture of key animal cells
11. Genetically modified natural killer immune cells attack, kill leukemia cells
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/15/2016)... , Dec. 14, 2016 "Increase in ... biometrics market" The mobile biometrics market is expected to ... 49.33 billion by 2022, at a CAGR of 29.3% ... factors such as the growing demand for smart devices, ... transactions. "Software component is expected to grow ...
(Date:12/8/2016)... , Dec. 8, 2016  Singulex, Inc., the leader ... technology, entered into a license and supply agreement with ... The agreement provides Singulex access to Thermo Scientific BRAHMS ... is used to diagnose systemic bacterial infection ... to aid in assessing the risk of ...
(Date:12/7/2016)... 2016   Avanade is helping Williams Martini ... in history, exploit biometric data in order to critically ... the competitive edge against their rivals after their impressive, ... Avanade has worked with Williams during the 2016 season ... (heart rate, breathing rate, temperature and peak acceleration) for ...
Breaking Biology News(10 mins):
(Date:1/20/2017)... ... January 20, 2017 , ... SpineFrontier, ... next evolution in spinal fusion, the MISquito Percutaneous Pedicle Screw System (part ... SpineFrontier is focused on technique driven product solutions that provide maximum efficiency ...
(Date:1/19/2017)... 2017 /PRNewswire -- WuXi AppTec, a leading global ... technology platform, today announced that it has acquired ... drug discovery contract research organization (CRO). After completion ... subsidiary of WuXi, and will continue to focus ... services. The acquisition will further strengthen WuXi,s R&D ...
(Date:1/19/2017)... GAITHERSBURG, Md. , Jan. 19, ... Altimmune, Inc., a privately-held immunotherapeutics company targeting infectious ... agreement for the merger of PharmAthene and Altimmune ... Novartis Venture Fund, HealthCap, Truffle Capital and Redmont ... and diversified immunotherapeutics company with four clinical stage ...
(Date:1/19/2017)... ... 18, 2017 , ... LabRoots , the leading provider ... world, was today awarded the "Best Science & Technology Social Networking Service 2016" ... decided upon by a dedicated team of researchers and analysts. , The 2016 ...
Breaking Biology Technology: