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How nature tinkers with the cellular clock

e a safety net when temporal control at the gene level fails, cells also regulate the activity of cell cycle proteins directly, switching them on and off and modifying them at particular sites. A closer look at these proteins revealed that changes in the control of gene expression often go together with changes in the regulation of the corresponding protein.

"To our surprise, we found that these two different mechanisms of temporal control evolve together in a coordinated fashion," says Søren Brunak, Professor at DTU. "This double layer of control seems so important that evolution has conserved it despite dramatic changes in the regulation of each mechanism."

The new insights gained have broad implications. The principles discovered might govern also the control of other temporally regulated systems like embryonic development. The fast evolution of temporal regulation also raises the question in how far general conclusions about regulatory systems can be drawn from studying simple model organisms like yeast or fruit flies.


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Source:European Molecular Biology Laboratory


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