Navigation Links
How mammals fuel milk production may have implications for cancer

the offspring of Akt2-deficient mice gained weight normally.

The researchers further showed that the mice without Akt1 displayed a four-fold reduction in milk secretion compared to either normal mice or mice lacking Akt2.

The findings represent some of the first to reveal functional differences between Akt1 and Akt2, the researchers said. The new findings show that Akt1 is uniquely essential for lactation and establish a role for the isoform in glucose metabolism, a function earlier linked almost exclusively to Akt2, they said.

The findings may have important implications for cancer therapy, as the Akt pathway is also one of the most commonly activated in cancer, Chodosh said.

“The metabolic demands of the lactating mammary epithelial cell bear many similarities to those of tumor cells in that pathways controlling energy generation as well as carbohydrate, protein, and lipid synthesis must be coordinated to support the anabolic processes central to growth,?the researchers wrote. “In this regard, Akt1’s ability to act as a central regulator of nutrient uptake and utilization is consistent with the frequent observation of constitutive activation of the PI3K/AKT pathway in a wide range of human cancers, including those of the breast.?

Cancer cells also commonly exhibit increased rates of glucose uptake as part of a shift toward a greater reliance on that sugar’s breakdown for energy, a phenomenon known as the Warburg effect. Such increased glycolytic metabolism in tumors is associated with increased tumor aggressiveness and poor prognosis, the researchers said.

“Our findings demonstrating a physiological requirement for Akt1 in the control of glucose and lipid metabolism further implicate Akt1 activation as a potential mediator of the Warburg effect and reinforce the importance of efforts to design pharmacologic agents that will inhibit this pathway in tumors.?
'"/>

Source:Cell Press


Page: 1 2 3

Related biology news :

1. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
2. Master gene controls healing of skin in fruit flies and mammals
3. Unlike other mammals, newborn dolphins and orcas stay active 24/7 during first months of development
4. Oxygen increase caused mammals to triumph, researchers say
5. Evolutionary conservation of a mechanism of longevity from worms to mammals
6. Marine mammals are on the frontline of failing ocean health
7. Avian influenza virus in mammals spreads beyond the site of infection to other organ systems
8. Insects and mammals share common fat-building pathway, study suggests
9. Yale researchers find environmental toxins disruptive to hearing in mammals
10. More evidence mammals, fruit flies share make-up on function of biological clocks
11. Elephants, large mammals recover from poaching in Africas oldest national park
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: How mammals fuel milk production may have implications for cancer

(Date:9/18/2014)... and ethnic groups describe losing eyesight as potentially ... more so than other conditions including: loss of ... 49% of non-Hispanic whites, 43% of Asians and ... ailment is the worst that could happen to ... AIDS/HIV. Hispanics and Asians ranked cancer first ...
(Date:9/18/2014)... Elsevier, a world-leading provider of scientific, technical and ... Research Management Society (ARMS), recognized the academic research ... Scopus Young Researcher of the Year Awards. , ... National Convention Centre and in conjunction with the ... representing Australia,s and New Zealand,s scientific community. Guest ...
(Date:9/18/2014)... protective tentacles of host anemones, but new research shows ... across the open ocean. Although the process of long-distance ... the first time that the high level exchange of ... Steve Simpson, Senior Lecturer in Marine Biology and Global ... the Australian Research Council Centre of Excellence for Coral ...
Breaking Biology News(10 mins):Americans rate losing eyesight as having greatest impact on their lives 2Americans rate losing eyesight as having greatest impact on their lives 3Elsevier and Australasian Research Management Society award scientists at Scopus ceremony 2Expedition finds Nemo can travel great distances to connect populations 2Expedition finds Nemo can travel great distances to connect populations 3
... diagnostics could be minutes particles of rust, iron oxide, ... silicon dioxide. These magnetic nanoparticles, a mere 29 to ... trap antibodies to the virus that causes cervical cancer ... According to scientists in Vietnam, it is relatively ...
... Scripps Research Institute scientists have converted adult skin ... to first go through the laborious process of generating ... lead to new treatments for a range of diseases ... heart disease, Parkinson,s, and Alzheimer,s disease. The work ...
... the dozens of antibiotics that followed it, streptococcus bacteria ... world. The reason: the superb evolutionary skills of this ... landmark paper published this week in Science , ... used full genome sequencing to identify the precise steps ...
Cached Biology News:Detecting lethal diseases with rust and sand 2Scripps Research scientists convert skin cells to beating heart cells 2Scripps Research scientists convert skin cells to beating heart cells 3New research traces evolutionary path of multidrug-resistant strep bacteria 2New research traces evolutionary path of multidrug-resistant strep bacteria 3
(Date:9/18/2014)... LONDON , Sept. 18, 2014 ... near-patient testing, is performed outside a clinical laboratory. ... hence in administrating appropriate treatments and medication. POCT ... and prevalence of lifestyle diseases such as diabetes, ... and user-friendly. POCT devices are standardized to minimize ...
(Date:9/18/2014)... , September 18, 2014 /PRNewswire/ ... Markets ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has announced ... Materials - Global Strategic Business Report" ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,This report analyzes the ... US$ Million by the following Product ...
(Date:9/18/2014)... 18, 2014 Research and Markets ... "Global N-acetylcysteine Industry Report 2014" report to ... Industry Report 2014 is a professional and in-depth ... N-acetylcysteine industry. The report provides a ... applications and industry chain structure. The N-acetylcysteine market ...
(Date:9/18/2014)... LOUIS , Sept. 18, 2014  U.S. biotech ... by signing an exclusive license for technology developed by ... control gene expression in plants, including for applications in ... The technology was developed under the ... officer at Kultevat and former president of the Danforth ...
Breaking Biology Technology:POCT Market in China 2014-2018 2Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Global N-acetylcysteine Industry Report 2014 2Kultevat obtains license of gene switch technology 2
... NEW YORK, Nov. 9, 2010 Reportlinker.com announces that ... catalogue: Biomarkers - technologies,markets and ... Summary This report follows ... that can be objectively measured and evaluated as an ...
... NeoStem, Inc. (NYSE Amex: NBS ) ("NeoStem" or ... U.S. and China, today announced that NeoStem,s Chairman and CEO, ... at Moves Magazine,s 2010 Power Women Awards Dinner & Ceremony ... Street, New York City. This event marks ...
... Nov. 9, 2010 /PRNewswire-Asia-FirstCall/ -- ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... function(data) { var s = ,; var first_result; // Results are keyed by longUrl, so we need to ...
Cached Biology Technology:Reportlinker Adds Biomarkers - Technologies, Markets And Companies 2Reportlinker Adds Biomarkers - Technologies, Markets And Companies 3Reportlinker Adds Biomarkers - Technologies, Markets And Companies 4Reportlinker Adds Biomarkers - Technologies, Markets And Companies 5Reportlinker Adds Biomarkers - Technologies, Markets And Companies 6Reportlinker Adds Biomarkers - Technologies, Markets And Companies 7Reportlinker Adds Biomarkers - Technologies, Markets And Companies 8Reportlinker Adds Biomarkers - Technologies, Markets And Companies 9Reportlinker Adds Biomarkers - Technologies, Markets And Companies 10Reportlinker Adds Biomarkers - Technologies, Markets And Companies 11Reportlinker Adds Biomarkers - Technologies, Markets And Companies 12Reportlinker Adds Biomarkers - Technologies, Markets And Companies 13Reportlinker Adds Biomarkers - Technologies, Markets And Companies 14Reportlinker Adds Biomarkers - Technologies, Markets And Companies 15Reportlinker Adds Biomarkers - Technologies, Markets And Companies 16Reportlinker Adds Biomarkers - Technologies, Markets And Companies 17Reportlinker Adds Biomarkers - Technologies, Markets And Companies 18Reportlinker Adds Biomarkers - Technologies, Markets And Companies 19Reportlinker Adds Biomarkers - Technologies, Markets And Companies 20NeoStem Chairman and CEO to be Honored at the Moves 2010 Power Women Awards 2China Biologic Products Schedules Conference Call to Discuss Third Quarter 2010 Results 2China Biologic Products Schedules Conference Call to Discuss Third Quarter 2010 Results 3China Biologic Products Schedules Conference Call to Discuss Third Quarter 2010 Results 4China Biologic Products Schedules Conference Call to Discuss Third Quarter 2010 Results 5China Biologic Products Schedules Conference Call to Discuss Third Quarter 2010 Results 6China Biologic Products Schedules Conference Call to Discuss Third Quarter 2010 Results 7China Biologic Products Schedules Conference Call to Discuss Third Quarter 2010 Results 8
Sheep Serum US Origin...
Human LAIR2 Biotinylated Affinity Purified PAb...
... Lacks the mycobacteria found in Complete Freund's Adjuvant ... Incomplete, Freund's Adjuvant is used ... used to produce water-in-oil emulsions of immunogens. ... long-lasting antibody responses which can be attributed to ...
HiTrap Streptavidin HP, 5 x 1 ml. Category: Chromatography Systems & Accessories, Systems....
Biology Products: