Navigation Links
How mammals fuel milk production may have implications for cancer

s three times its total body weight in milk, which consists of lipid, protein, and lactose. To accomplish this, two distinct developmental programs must be executed: first, cells must proliferate and differentiate to form the structures that will ultimately serve as the site of milk synthesis, the researchers said. Second, mammary epithelial cells must coordinately activate multiple biosynthetic pathways—as well as deactivate pathways that break lipids down—in order to have the metabolic capacity to synthesize large quantities of milk.

Earlier studies by the researchers found that the protein kinase Akt1 rises in concentration during pregnancy and lactation, suggesting a potential developmental role for the kinase in milk production. Another study showed that permanent activation of Akt1 in the mammary glands of mice leads to early lipid accumulation during pregnancy, raising the possibility that the gene might be important in the increased synthetic demand for lipid during lactation.

To further investigate, in the current study, the researchers examined mice lacking either Akt1 or the related gene Akt2, which are expressed in the same areas of the mammary gland at distinct developmental stages. While Akt1 protein increases during pregnancy and lactation, Akt2 levels decline.

Indeed, the researchers found that the mammary gland cells of Akt1-deficient mice failed to engage critical metabolic pathways during the transition from pregnancy to lactation, which in turn led to other deficiencies. Specifically, the mammary cells failed to increase their uptake of glucose, cells?primary energy source, and their synthesis of lipid. The cells also did not lower the level of enzymes that break down lipids.

As early as two days after birth, pups nursed by mice lacking Akt1 weighed significantly less than those nursed by normal mothers. That difference in weight only grew more exaggerated with time. In contrast, the researchers reported,
'"/>

Source:Cell Press


Page: 1 2 3

Related biology news :

1. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
2. Master gene controls healing of skin in fruit flies and mammals
3. Unlike other mammals, newborn dolphins and orcas stay active 24/7 during first months of development
4. Oxygen increase caused mammals to triumph, researchers say
5. Evolutionary conservation of a mechanism of longevity from worms to mammals
6. Marine mammals are on the frontline of failing ocean health
7. Avian influenza virus in mammals spreads beyond the site of infection to other organ systems
8. Insects and mammals share common fat-building pathway, study suggests
9. Yale researchers find environmental toxins disruptive to hearing in mammals
10. More evidence mammals, fruit flies share make-up on function of biological clocks
11. Elephants, large mammals recover from poaching in Africas oldest national park
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: How mammals fuel milk production may have implications for cancer

(Date:12/24/2014)... YORK , Dec. 23, 2014  Since its launch ... helped thousands of people to eliminate the pain of ... the antiquated system with their own biometrics fused to ... remember usernames and passwords, Hoyos Labs , the ... announced today that it is offering the app for ...
(Date:12/22/2014)... Conn. , Dec. 22, 2014  NXT-ID, Inc. ... the "Company"), a biometric authentication company focused on the ... pickpocket, entertainer and security consultant, Apollo Robbins ... biometric smart wallet.  Apollo Robbins ... and 7 th , 2015, demonstrating some of his ...
(Date:12/22/2014)... DUBLIN , Dec. 22, 2014 /PRNewswire/ ... ) has announced the addition of the ... report to their offering. ... This insight provides an overview of the ... Watermarking aims to control and monitor piracy ...
Breaking Biology News(10 mins):1U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4The Global Watermarking and Fingerprinting Markets 2
... Institute for Animal Health, Pirbright, UK Met Office and ... are working together on an early-warning system to help ... a study published today in Weather . The ... anticipate when disease carrying midges are likely to be ...
... PHILADELPHIA People with the heritable disorder of the ... develop basal cell carcinoma of the skin may have ... According to results of a placebo-controlled, randomized, double-blind, Phase ... inhibiting the development of basal cell carcinomas in a ...
... at University College London say they have gleaned a key ... No. 1 cause of vision loss in the elderly, by ... onset of the condition. In a paper to be ... Biological Chemistry , the team reports for the first time ...
Cached Biology News:Scientists create early-warning system to defend rare Jersey cows from continental disease 2Celebrex inhibited the burden of skin cancer in high-risk patients 2New research findings may help stop age-related macular degeneration at the molecular level 2
(Date:12/24/2014)... Texas , Dec. 23, 2014 ... company focused on gynecologic disease, announced today that ... Schuler , Birchview Fund LLC and several Vermillion ... of unregistered shares of Vermillion,s common stock and ... stock in a private placement.  ...
(Date:12/24/2014)... Fla. , Dec. 23, 2014  Rock Creek ... that it has filed a Clinical Trial Application (CTA) ... Healthcare products Regulatory Agency (MHRA) seeking regulatory approval to ... lead molecule, Anatabine Citrate. Contingent on the ... conduct a Phase I trial to assess the safety, ...
(Date:12/22/2014)... 22, 2014   Synthetic Biologics, Inc. ... pathogen-specific therapies for serious infections and diseases, ... today announced positive topline safety and tolerability ... of SYN-004, the Company,s investigational oral beta-lactamase ... difficile (C. difficile) infection, antibiotic-associated diarrhea ...
(Date:12/22/2014)... , Dec. 22, 2014 GenomeDx Biosciences today ... Prostate Cancer Classifier, a genomic test for prostate cancer, ... high-risk men managed by radical prostatectomy without adjuvant therapy. ... is relatively uncommon, using tumor genomics to identify these ... disease is an important advance. The study has been ...
Breaking Biology Technology:Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3
... boxes tend to get sulky and intractable when they encounter ... in the data stream. They're a little like us that ... our own intractability, assuming we recognize it and choose to ... people who begin to look like their pets. Do we ...
... and Human Services Secretary Mike Leavitt announced yesterday that ... will be formed to make recommendations for a nationwide ... , ,This news makes the Digital Healthcare Conference ... 9 at the Fluno Center in Madison, even more ...
... experiences were passed down to new businesses at the ... 8 in Milwaukee at the Hyatt Regency. , ,New ... providers converged at the conference to learn techniques and ... for their ability to meet challenges and come away ...
Cached Biology Technology:Machine like me 2Machine like me 3Preview: Electronic health records, tech choices explored at Digital Healthcare Conference 2Preview: Electronic health records, tech choices explored at Digital Healthcare Conference 3Conference focuses on experience, challenges of being an entrepreneur 2Conference focuses on experience, challenges of being an entrepreneur 3Conference focuses on experience, challenges of being an entrepreneur 4
...
Reacts with the 80 kDa fragment of the M-chain of human merosin....
Mouse anti-JNK (PT183/185) Class: Antibody Product Group: Signalling molecules and phospho-specific Antibody...
ICAD / DFF45 (NT) Affinity Purified Polyclonal Antibody...
Biology Products: