Navigation Links
How mammals fuel milk production may have implications for cancer

s three times its total body weight in milk, which consists of lipid, protein, and lactose. To accomplish this, two distinct developmental programs must be executed: first, cells must proliferate and differentiate to form the structures that will ultimately serve as the site of milk synthesis, the researchers said. Second, mammary epithelial cells must coordinately activate multiple biosynthetic pathways—as well as deactivate pathways that break lipids down—in order to have the metabolic capacity to synthesize large quantities of milk.

Earlier studies by the researchers found that the protein kinase Akt1 rises in concentration during pregnancy and lactation, suggesting a potential developmental role for the kinase in milk production. Another study showed that permanent activation of Akt1 in the mammary glands of mice leads to early lipid accumulation during pregnancy, raising the possibility that the gene might be important in the increased synthetic demand for lipid during lactation.

To further investigate, in the current study, the researchers examined mice lacking either Akt1 or the related gene Akt2, which are expressed in the same areas of the mammary gland at distinct developmental stages. While Akt1 protein increases during pregnancy and lactation, Akt2 levels decline.

Indeed, the researchers found that the mammary gland cells of Akt1-deficient mice failed to engage critical metabolic pathways during the transition from pregnancy to lactation, which in turn led to other deficiencies. Specifically, the mammary cells failed to increase their uptake of glucose, cells?primary energy source, and their synthesis of lipid. The cells also did not lower the level of enzymes that break down lipids.

As early as two days after birth, pups nursed by mice lacking Akt1 weighed significantly less than those nursed by normal mothers. That difference in weight only grew more exaggerated with time. In contrast, the researchers reported,
'"/>

Source:Cell Press


Page: 1 2 3

Related biology news :

1. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
2. Master gene controls healing of skin in fruit flies and mammals
3. Unlike other mammals, newborn dolphins and orcas stay active 24/7 during first months of development
4. Oxygen increase caused mammals to triumph, researchers say
5. Evolutionary conservation of a mechanism of longevity from worms to mammals
6. Marine mammals are on the frontline of failing ocean health
7. Avian influenza virus in mammals spreads beyond the site of infection to other organ systems
8. Insects and mammals share common fat-building pathway, study suggests
9. Yale researchers find environmental toxins disruptive to hearing in mammals
10. More evidence mammals, fruit flies share make-up on function of biological clocks
11. Elephants, large mammals recover from poaching in Africas oldest national park
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: How mammals fuel milk production may have implications for cancer

(Date:7/11/2014)... started near the City of Entiat on Tuesday, July ... fire quickly grew to over 1,000 acres by evening. ... is under investigation by the Washington Department of Natural ... local resources in developing fire control strategies and tactics. ... State Department of Natural Resources, (WA DNR), Bureau of ...
(Date:7/11/2014)... "mouse TRAP" to capture the early signs of kidney ... the Journal of Clinical Investigation . Their new ... extract cellular and genetic information from a variety of ... Institute for Medical Research in 2008, TRAP involves attaching ... of the cell type of interest. Scientists can then ...
(Date:7/11/2014)... with other group members to reduce aggression and gain ... strategy for grooming activities shows a certain pattern across ... scientific journal Biology Letters . , Grooming between ... without ulterior motives. To be groomed has hygienic benefits ... another individual can provide access to infants, mating opportunities ...
Breaking Biology News(10 mins):Baboons groom early in the day to get benefits later 2
... Boston, Mass. A computational physicist and a cognitive ... the beginnings of a noninvasive test to evaluate an ... which records electrical activity in the brain, with machine-learning ... percent accuracy in distinguishing between 9-month-old infants known to ...
... cycle, helping sequester significant amounts of carbon. Some algal ... discolor coastal waters and reduce the amount of light ... "red tide," the term "harmful algal blooms" (HABs) was ... biomass can sometimes also turn the ocean waters brown ...
... Cross-disciplinary teams of scientists studying genetic pathways that ... also cause certain forms of congenital heart disease ... muscle that is the leading cause of sudden death ... mutations into mice and successfully treated HCM in the ...
Cached Biology News:Using EEGs to diagnose autism spectrum disorders in infants 2Using EEGs to diagnose autism spectrum disorders in infants 3Brown tide culprit sequenced: Genome of the first of algal bloom species 2Brown tide culprit sequenced: Genome of the first of algal bloom species 3Brown tide culprit sequenced: Genome of the first of algal bloom species 4Cancer-related pathways reveal potential treatment target for congenital heart disease 2Cancer-related pathways reveal potential treatment target for congenital heart disease 3
(Date:7/10/2014)... Deep Knowledge Ventures last week ... ‘Commercialising Longevity Research’ and welcomed a host of ... Bioscience Innovation Center for the event, organised by ... Ltd. The meeting highlighted the need for both ... age-related disease, as well as the crucial role ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Unraveling life’s ... together. The Archer Family purchased a DNA ... DNA, but ended up with a lifetime of memories, ... within the family members’ DNA genuinely brought the family ... to search deeper into genetic history and prior to ...
(Date:7/10/2014)... EvoDerma ’s NOOME Anti-Aging Motion has been upgraded for ... a second treatment cup to help prevent and smooth skin ... thinner on the edges for a softer contact with the ... surfaces on the face, neck and décolleté. Choose to use ... such as the cheeks and neck, or opt for the ...
(Date:7/10/2014)... July 10, 2014 On July ... Medvedev , presented Russia,s first ... . The Company is developing a unique project called ... BIOCAD develops a number of innovative drugs based on ... The ceremony took place at the International Exhibition "Innoprom ...
Breaking Biology Technology:DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2
... up by 48% at EUR958 Million - EBITDA Margin ... the Target Segment of Pharmaceutical Plastics,in South America: Brazilian ... to provisional figures, Gerresheimer AG has just completed,another record ... up by,48.1%; the adjusted Group EBITDA margin reached 19%. ...
... think a lot about "Homeland Security," but one Montana ... home gardeners also serves to keep us safe from ... the Bozeman campus recently received a five-year grant for ... the lab provides an early warning system of biological ...
... manufactured product our clothes, money, appliances, the paint ... cars will be embedded with intelligence, networks of ... dust or an Internet of Things. The world of ... have surveillance systems, biometrics, personal communicators, machine learning and ...
Cached Biology Technology:2007 Another Record Year in Terms of Sales and Earnings for Gerresheimer 22007 Another Record Year in Terms of Sales and Earnings for Gerresheimer 3Montana State University lab gives early warnings about biological invaders 2Montana State University lab gives early warnings about biological invaders 3Supportive devices or unnecessary surveillance? 2