Navigation Links
How genetic malfunction causes a form of retardation

Researchers have discovered that the genetic malfunction that causes a form of mental retardation called Noonan Syndrome (NS) produces an imbalance in the genesis of two types of cells in the developing embryonic brain. This imbalance, they theorize, could explain how the genetic abnormality gives rise to the neural pathology of the disorder. More broadly, they said, the new insight into the mechanism underlying NS could apply to other inherited forms of retardation.

Freda Miller of the Hospital for Sick Children and University of Toronto and colleagues published their findings in the April 19, 2007 issue of the journal Neuron, published by Cell Press.

NS is a relatively common genetic disorder, occurring in one of every 2,500 live births. It is characterized by congenital heart defects, short stature, learning disabilities, and mental retardation. Approximately 50% of NS cases are caused by a genetic mutation in a biochemical switch called SHP-2. SHP-2 is involved in molecular pathways regulating development of brain cells. The NS mutations cause SHP-2 to be constantly activated.

Specifically, SHP-2 plays a role in the pathways governing differentiation of immature precursor cells into neurons and glial cells. Unlike neurons, which conduct nerve impulses, glial cells are supporting cells that surround neurons and insulate them from one another.

In experiments with cultured precursor cells, the researchers found that SHP-2 activates the regulatory pathway that causes genesis of neurons and inhibits the pathway that generates glial cells. And in experiments with both cell cultures and mouse embryos, they found that the same kind of mutation in SHP-2 that can be found in NS patients disrupts the neuron-glial balance by further promoting the formation of neurons and inhibiting glial cell formation.

The researchers also studied the effects of the mutation in mice engineered to mimic the human disorder. Like humans with NS, the mice had only one mutant copy of the SHP-2 gene, while the other was normal. The researchers observed in the animals?brains increases in neuron density and percentage, as well as a large decrease in glial cells called astrocytes.

“Little is known about how genetic perturbations lead to mental retardation,?wrote Miller and colleagues. “Here, we have identified a signaling protein, SHP-2, that plays a key role in allowing environmental cues such as growth factors to instruct multipotent precursor cells to generate one cell type versus another. Moreover, we have shown that the same constitutively activated SHP-2 that occurs in a subpopulation of NS patients causes aberrant neural development in mice, providing a potential explanation for the cognitive dysfunction and neuroanatomical perturbations observed in this disorder. Such a mechanism may well generalize to other syndromes where signaling pathways that are important for neural cell genesis are genetically perturbed.?

The researchers speculated that “genetic perturbations such as those seen in NS, or perhaps even in more commonly studied disorders such as Rett Syndrome, might first perturb cell genesis, and then this might in turn alter many later aspects of neural development, ultimately resulting in impaired circuitry and cognitive dysfunction.?


'"/>

Source:Cell Press


Related biology news :

1. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
2. Scientists detect probable genetic cause of some Parkinsons disease cases
3. Mouse brain tumors mimic those in human genetic disorder
4. Scientists identify genetic pathways essential to RNA interference
5. Researchers trace evolution to relatively simple genetic changes
6. Key mechanism in genetic inheritance during cell division identified
7. Scientists identify genetic pathways essential to RNA interference
8. MUHC scientists describe genetic resistance to rampant virus
9. Mosaic mouse technique offers a powerful new tool to study diseases and genetics
10. Montreal researchers probe the genetic basis of memory
11. Biologists determine genetic blueprint of social amoeba
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/9/2017)... 9, 2017 The biomass boiler market report ... biomass boiler market globally in terms of revenue (US$ ... The market for biomass boilers has been segmented on ... and country/region. The market based on feedstock type, has ... biogas & energy crops, urban residues, and others. On ...
(Date:2/8/2017)... Report Highlights The global biosurgery ... billion in 2016 at a compound annual growth rate ... Includes - An overview of the global market for ... from 2015 and 2016, and projections of compound annual ... market on the basis of product type, source, application, ...
(Date:2/3/2017)... 3, 2017  Texas Biomedical Research Institute announced that its ... Schlesinger as the Institute,s new President and CEO. Dr. ... 31, 2017. He is currently the Chair of the Department ... for Microbial Interface Biology at Ohio State University. ... President and CEO of Texas Biomed," said Dr. James ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... Dublin - Research and Markets has ... Market-By Type, By Application, By End User, By Region, By Country: ... ... Market is forecasted to grow at a CAGR of 11.33% during ... crop protection market is driven by the surging demand for less ...
(Date:2/22/2017)... , ... February 22, 2017 , ... ... Dr. Daniel Spyker, PhD, MD former Acting Deputy Director in the FDA CDRH ... Drug Evaluation Staff has joined the company as an Expert Consultant. , In ...
(Date:2/22/2017)... and RESEARCH TRIANGLE PARK, N.C., Feb. 22, 2017 /PRNewswire/ ... today announced its financial results for the fourth ... "Our annual 2016 financial results reflect continued growth ... exceeded $700 million," said Martine Rothblatt, Ph.D., United ... results strengthen our ability to develop and advance ...
(Date:2/21/2017)... ... February 21, 2017 , ... During HIMSS 2017, ... health applications, announced a partnership with Redox, a leader in cloud-based healthcare integration ... clinical systems while keeping data secure in the cloud. , The digital health ...
Breaking Biology Technology: