Navigation Links
How fish mend a broken heart

New evidence to explain how a common tropical fish mends a broken heart may suggest methods for coaxing the damaged hearts of mammals to better heal, researchers report in the November 3, 2006 issue of Cell, published by Cell Press.

The researchers found that the hearts of zebrafish harbor progenitor cells that spring into action to restore wounded heart muscle. Cells from a membrane layer that surrounds the heart, called the epicardium, follow suit, invading the wounded cardiac tissue and stimulating the growth of new blood vessels.

"Zebrafish can survive pretty massive injury to the heart--the loss of about a quarter of their ventricle," said Kenneth Poss of Duke University Medical Center. The ventricle, which receives blood and then pumps it back out to the body, is one of two chambers that make up the fish heart. "This study gets at some of the important mechanistic questions about how they rebuild the heart, and some of the key factors that contribute."

In contrast to zebrafish, the cardiac damage and scarring caused by heart attacks is a major killer among humans, making "the inability to replace damaged cardiac muscle one of the most prominent regenerative failures of mammals," wrote Alexandra Lepilina and Ashley Coon, the study's first authors.

However, mammalian hearts have been found to contain rare populations of progenitor cells, they added. As in zebrafish, the hearts of adult mammals, including humans, are also housed inside an epicardium, a tissue about which little is known.

"Scientists haven't paid much attention to the epicardium in adults," Poss said. "These findings in fish should encourage more exploration of what adult epicardium can do.

"There is the potential that these cells could be utilized for therapies."

The ability to regenerate tissue is a feature shared among vertebrate species, the researchers said. However, particular animals, including certain amphibians and fish, display an "elevated regenerative spectrum, with many more tissues capable of impressive regeneration," they said. For instance, certain newts or salamanders can regenerate limbs, spinal cord, retina, brain, and heart tissue.

While progenitor cell populations have been identified within most mammalian organs, including skin, skeletal muscle, brain, and heart, these cells vary widely in frequency and the ability to regenerate damaged or lost tissue, they said. In most mammalian organs, progenitor cells can restore cells lost in the course of normal organ function or after minor injury but cannot regenerate after major damage or removal of structures.

"It is believed that the capacity for regeneration is an ancestral condition that has occasionally been lost in the course of vertebrate evolution." Poss said. "Thus, most biologists suspect that the machinery to optimize regeneration from progenitor cells is present, but lies dormant, in mammals."

In an earlier study, Poss and his colleagues found that zebrafish have a unique ability to regenerate cardiac muscle after major injury. They further suspected that illumination of the fishes' ability might offer important insights into "how heart regeneration is naturally optimized."

In the current study, they found that heart regeneration proceeds through two coordinated stages. First, a mass of undifferentiated, pre-cardiac cells form. Those progenitor cells then begin to differentiate and divide, to replace the damaged heart muscle.

In the second step, the epicardium surrounding the heart chambers "lights up" with activity as developmental genes switch on, Poss said. The epicardium expands to rapidly cover the wounded heart muscle.

A subset of those epicardial cells then alters their identity, invading the wound and providing essential new blood vessels to the growing muscle.

They further found that the two-part regeneration process is coordinated by so-called "fibrob last growth factor" (Fgf) signals. Fgf signals are known for their ability to encourage invasive cell behavior, Poss explained.

Indeed, they found, heart muscle cells produce the growth factor, while epicardial cells harbor receptors that are triggered by the signal. When the researchers experimentally blocked the Fgf signal, heart regeneration failed.

"It is tempting to speculate that the ability to mobilize epicardial cells and cultivate such a cardiogenic environment is a primary reason why zebrafish, as opposed to other laboratory models, effectively regenerate [heart muscle]," the researchers concluded. Indeed, they added, mammalian hearts typically show insufficient blood vessel growth after a heart attack.

"Experimental attempts to modify this deficiency are underway, including delivery of growth factors or bone marrow-derived cells that may promote [the formation of new blood vessels]…Success in these pursuits or by directly utilizing epicardial cells or their progenitors could prove favorable for encouraging regeneration from mammalian cardiac progenitor cells."


'"/>

Source:Cell Press


Related biology news :

1. Single stem cells from bone heal a broken heart
2. Nanotubes inspire new technique for healing broken bones
3. UCLA imaging study of children with autism finds broken mirror neuron system
4. UT Southwestern researchers find gene mutation that leads to broken hearts
5. Tracing broken wiring in stroke patients
6. Global study shows all tobacco bad for the heart
7. New study shows antibiotic may protect the heart
8. Getting to the heart of the heart
9. Slowing the racing heart
10. Hawaiian treasure, macadamia nuts good for the heart
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/14/2016)... 2016 http://www.apimages.com ) - ... - Renvoi : image disponible via AP Images ... --> DERMALOG, le leader de ... lecteurs d,empreintes digitales pour l,enregistrement des réfugiés en ... pour produire des cartes d,identité aux réfugiés. DERMALOG ...
(Date:3/10/2016)... --> --> ... and Access Management Market by Component (Provisioning, Directory Services, ... Organization Size, by Deployment, by Vertical, and by Region ... market is estimated to grow from USD 7.20 Billion ... a Compound Annual Growth Rate (CAGR) of 12.2% during ...
(Date:3/9/2016)... , March 9, 2016 ... identified that more than 23,000 public service employees either ... been receiving their salary unlawfully.    --> ... government identified that more than 23,000 public service employees ... had been receiving their salary unlawfully.    --> ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... ... April 28, 2016 , ... Next week ... talk on its first-in-class technologies for tissue stem cell counting and expansion to ... Biology to Reprogramming & CRISPR-based Genome Engineering in Burlington, Massachusetts. , The attention ...
(Date:4/27/2016)... ... April 27, 2016 , ... The Pittcon Organizing Committee is pleased ... has been a volunteer member of Committee since 1987. Since then, he has served ... and treasurer and was chairman for both the program and exposition committees. In his ...
(Date:4/27/2016)... ... 27, 2016 , ... NDA Partners Chairman Carl Peck, ... Expert Consultant. Mr. Clark was formerly a Vice President with US Pharmacopeia, ... molecule monographs based on analytical methods. NDA Partners Expert Consultants are top ...
(Date:4/27/2016)... 27, 2016 MedDay, a biotechnology company ... the appointment of Catherine Moukheibir as Chairman of its Board ... Jean Jacques Garaud , who contributed to the rapid ... immediately. Catherine started her career in strategy consulting ... London .  She held C-Suite level roles ...
Breaking Biology Technology: