Navigation Links
How exactly does the brain control breathing?

An understanding of exactly how the brain controls breathing is fundamental to the treatment of respiratory disorders. We know that breathing is an automatic rhythmic process that persists without conscious effort whether we are awake or asleep, but the question that has intrigued many scientists for well over 100 years is what maintains this almost fail safe vital rhythm throughout life?

Experimental Physiology editor Julian Paton invited two world renowned scientists Dr. Guyenet from the University of Charlottesville and Dr. Richerson from Yale University, to use the journal as a forum to discuss the issue and attempt to resolve their differences in opinion.

Both authors agree that the respiratory rhythm requires specialised nerve cells (central chemoreceptors) to power the rhythm, but the issue highly debated by Guyenet and Richerson is the precise location and cell types involved. Guyenet proposes that these nerve cells are located in a ventral area of the brainstem (the retrofacial region) and loaded with a transmitter substance called glutamate. Their close proximity to the ventral surface of the brain allows them to sense and react to changes in the pH of the cerebrospinal fluid; this is deemed an essential property of a central chemoreceptor. Richerson, on the other hand, stipulates that central chemoreceptors are found close to the midline blood vessels of the brainstem allowing them to 'taste' the pH of the blood. His cells do not contain glutamate but a substance called serotonin.

Experimental Physiology asked each author to stake out his claim and provide rebuttals and critiques of each others' articles (recently published in Nature Neuroscience).

To view this fascinating exchange of views published in Experimental Physiology-

Retrotrapezoid nucleus: a litmus test for the identification of central chemoreceptors
Patrice G. Guyenet, Ruth L. Stornetta, Douglas A. Bayliss and Daniel K. Mulkey
Exp Physiol 90 .3, pg.247

Homing in on the specific phenotype(s) of central respiratory chemoreceptors
G. B. Richerson, W. Wang, M. R. Hodges, C. I. Dohle, A. Diez-Sampedro
Exp Physiol 90.3, pg.259

Respiratory control by ventral surface chemoreceptor neurons in rats. Nature Neuroscience, 7(12), 1360-1369. Mulkey, DK, Stornetta, RL, Weston, MC, Simmons, JR, Parker, A, Bayliss, DA & Guyenet, PG (2004).

Midbrain serotonergic neurons are central pH chemoreceptors. Nature Neuroscience. Vol. 6(11), 1139-1140 Severson CA. Wang W. Pieribone VA. Dohle CI. Richerson GB. (2003).


'"/>

Source:Blackwell Publishing Ltd.


Related biology news :

1. Controversial drug shown to act on brain protein to cut alcohol use
2. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
3. Mouse brain tumors mimic those in human genetic disorder
4. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
5. First atlas of key brain genes could speed research on cancer, neurological diseases
6. NYU study reveals how brains immune system fights viral encephalitis
7. Stem cells from brain transformed to produce insulin at Stanford
8. Birds brains reveal source of songs
9. Loves all in the brain: fMRI study shows strong, lateralized reward, not sex, drive
10. Revolutionary nanotechnology illuminates brain cells at work
11. A puzzle piece found in unraveling the wiring of the brain
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2017)... 2017   ivWatch LLC , a medical device company focused ... announced receipt of its ISO 13485 Certification, the global standard for ... for Standardization (ISO®). ... 400 Continuous Monitoring device for the early detection of IV infiltrations. ... "This is an important milestone for ivWatch, ...
(Date:7/20/2017)... Delta (NYSE: DAL ) customers now can use fingerprints instead ... National Airport (DCA). ... Delta launches biometrics to board aircraft at Reagan Washington National Airport ... Delta,s biometric boarding pass experience that launched in ... the boarding process to allow eligible Delta SkyMiles Members who are enrolled ...
(Date:6/30/2017)... , June 30, 2017 Today, American ... and supplier of face and eye tracking software, ... Product provider program. "Artificial intelligence ... way to monitor a driver,s attentiveness levels while ... being able to detect fatigue and prevent potential ...
Breaking Biology News(10 mins):
(Date:8/18/2017)... ... August 18, 2017 , ... ... they will feature Federal Hybrids, Inc. in an upcoming episode, scheduled to broadcast ... American Farmer will explore Federal Hybrids, the independent, family-owned seed company. Educating audiences ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... for the Semiconductor, MEMS, and Microfluidics Industries, announces the new Model 800E front ... more often in automated production mask aligners. OAI has already received and ...
(Date:8/17/2017)... Springs, FL (PRWEB) , ... August 17, 2017 ... ... announced that the stock market news outlet had provided a research update on ... company's nasally administered TRT product. , According to Soulstring, prescription rates for Natesto® ...
(Date:8/17/2017)... (PRWEB) , ... August 17, 2017 , ... ... cancer research and personalized medicine, today announced the launch of a new breast ... Missouri. The study’s goal is to evaluate the potential for early detection of ...
Breaking Biology Technology: