Navigation Links
How cell suicide protects plants from infection

Researchers at Yale have identified a gene that regulates the major immune response in plants, programmed cell death (PCD), according to a recent report in the journal Cell.

To protect themselves from viruses, plants create a zone of dead cells around an infection site that prevents the infection from spreading. Savithramma Dinesh-Kumar, associate professor of Molecular, Cellular and Developmental Biology at Yale and his colleagues discovered how the plants keep from killing themselves after they turn on the cell-suicide PCD process.

Dinesh-Kumar first developed a technique for silencing or inactivating plant genes -- a technique that is now used by several research groups. His group studies the interaction between plants and viruses using tobacco as a model system.

They identified and silenced a "pro-survival" gene, BECLIN-1, that is important in the PCD response. When BECLIN-1 is active, infection is localized to a small number of cells that later die and form discrete brown lesions on the leaves. When the gene is inactivated, the plant can no longer regulate PCD, leading to cell death throughout the leaf and plant.

PCD has been described in virtually all cell types, both plant and animal. It is an important aspect of many biological processes including immune system function, embryonic development and elimination of defective cells. Failure of PCD can result in devastating diseases such as cancer, Alzheimer's and AIDS.

"This work gives us a better understanding of how plants fend off microbial attacks through carefully controlled destruction of infected cells," said James Anderson, of the Division of Genetics and Developmental Biology at the National Institute of General Medical Sciences (NIGMS). "Like other studies carried out in model organisms, these findings shed light on similar processes that occur in mammals, and may eventually be used to better human health."


'"/>

Source:Yale University


Page: 1

Related biology news :

1. University of Minnesota researchers take new look at cellular suicide
2. Protein averts cell suicide but might contribute to cancer
3. Bound for destruction: Ubiquitination protects against improper Notch signaling
4. Experiments provide proof of how traveling in groups protects insects
5. Experiments provide proof of how traveling in groups protects insects
6. Substance protects resilient staph bacteria
7. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
8. NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses
9. Mutation in clams protects against paralytic shellfish poisoning but raises human health risk
10. Excess liver gene protects against high-fat diet
11. New vaccine protects more effectively against tuberculosis
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/16/2016)... DUBLIN , Dec 16, 2016 Research ... Access System Market - Global Forecast to 2021" report to ... ... projected to grow at a CAGR of 14.06% from 2016 to ... 2016, and is projected to reach 854.8 Million by 2021. The ...
(Date:12/15/2016)... --  WaferGen Bio-systems, Inc. (NASDAQ: WGBS ... that on December 13, 2016, it received a letter ... Market LLC which acknowledged that, as of December 12, ... had been at $1.00 or greater for ten consecutive ... Rule 5550(a)(2) of the Nasdaq Stock Market. ...
(Date:12/15/2016)... 2016  There is much more to innovative access ... engine. Continental will demonstrate the intelligence of today,s solutions ... . Through the combination of the keyless entry and ... elements, the international technology company is opening up new ... "The integration of biometric elements brings our ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... Berkeley, CA (PRWEB) , ... January 19, 2017 ... ... the delivery of product vigilance software to leading biopharmaceutical and medical device manufacturers ... Mail is a fully 21 CFR Part 11-compliant email client designed to provide ...
(Date:1/19/2017)... 2017  ArmaGen, Inc., today announced that it ... chief executive officer, as well as a member ... ArmaGen more than 17 years of executive management ... biotherapeutics and pharmaceuticals. "Mathias is ... and skillset necessary to lead ArmaGen to its ...
(Date:1/19/2017)... , ... January 18, 2017 , ... ... Institutes of Health (NIH) to update its Data Sharing Policy. Specifically, the nation’s ... of grant applications subject to the existing policy. AMIA recommended that NIH earmark ...
(Date:1/19/2017)... ... January 19, 2017 , ... FireflySci Inc. is a go-getter ... The tremendous growth is accounted to two main factors. The first is the ... network of vendors supplying FireflySci products all around the world. , 2016 was a ...
Breaking Biology Technology: