Navigation Links
How can identical twins be genetically different?

They sleep together, eat together, and most people find it impossible to tell them apart. Identical twins who grow up together share just about everything, including their genes. But sometimes only one twin will have health problems when genetics predicts both of them should.

Scientists at the University of Michigan Medical School are just beginning to understand how two people who are so similar biologically can be so different when it comes to the development of diseases like rheumatoid arthritis.

U-M researchers have discovered three genes that are over-expressed in rheumatoid arthritis, or RA, that were not known to be associated with the disease before. They also found that non-genetic factors influenced the expression of these genes and that the expression patterns varied between identical twins where only one twin had RA. Results of the U-M study were published in the July issue of Arthritis and Rheumatism.

RA is a chronic inflammatory disease that damages joints. RA causes pain, loss of movement, and bone deformities. It affects 2.1 million Americans. There are many genetic factors that put people at a high-risk for developing RA, yet only 15 percent of identical twins will both develop it.

Scientists compared gene expression patterns of 11 pairs of monozygotic twins, who shared the same egg and were genetically identical, but only one of them had RA. They found three new genes that were significantly over-expressed in the twin with RA compared to the one without the disease. This is the first report for RA that examines gene expression patterns in monozygotic twins.

"This is the crux of the issue we are trying to address in RA -- how two patients can have the same genes but different disease outcomes. Identical twins represent the best experimental system to address this question," says Joseph Holoshitz, M.D., an associate professor of internal medicine at U-M Medical School and co-author of the study.

T
'"/>

Source:University of Michigan Health System


Page: 1 2 3

Related biology news :

1. UCLA scientists discover immune response to HIV differs, even in identical twins
2. Cloned stem cells prove identical to fertilized stem cells
3. Identical twins may have more differences than meet the eye
4. Study finds that a womans chances of having twins can be modified by diet
5. Are dancers genetically different than the rest of us? Yes, says Hebrew University researcher
6. Researchers report technique for freezing and preserving genetically enhanced pig embryos
7. Researchers create genetically matched embryonic stem cells for transplantation
8. Science researchers genetically transform immune cells into tumor fighters
9. Scientists genetically engineer tomatoes with enhanced folate content
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: How can identical twins genetically different

(Date:9/30/2014)... in German . ... expensive foods in the world. Because they grow underground, people ... distinctive smell of truffles is not only of interest to ... direction of the Goethe University Frankfurt have discovered that the ... which are trapped inside truffle fruiting bodies. , White truffles ...
(Date:9/30/2014)... getting pregnanteven with IVF? Here,s some hope: A new ... The FASEB Journal , explains how scientists ... as PAWP, which induced embryo development in human and ... development by the sperm cell during fertilization. , "We ... major paradigm shift in our understanding of human fertilization ...
(Date:9/30/2014)... , Sept. 30, 2014 Winners of The Economist,s ... Innovation Summit scheduled to take place at the JW Marriott Hong ... the award winners will share their experiences and the lessons those ... made a proven innovation over the past decade, will be presented ... night before the summit. It will be the first time the ...
Breaking Biology News(10 mins):On the trail of the truffle flavor 2Synthetic sperm protein raises the chance for successful in vitro fertilization 2Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 2Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 3Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 4Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 5Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 6Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 7
... ORLANDO, Nov. 6 Downing an energy drink may ... in a small study presented at the American Heart ... Wayne State University researchers, blood pressure and heart rate ... a day of a popular energy drink., While the ...
... has published a new analysis showing that as plant species ... and contain fewer total plants a situation that could ... The article is to appear in the online ... the week of Nov. 5. The process by which ...
... today its involvement in an expanded access program ... for phenylketonuria (PKU), a rare genetic metabolic disorder ... can result in severe mental retardation. Currently, there ... program at Nationwide Childrens. Under an expanded ...
Cached Biology News:Energy drinks may pose risks for people with high blood pressure, heart disease 2Energy drinks may pose risks for people with high blood pressure, heart disease 3Scientists warn that species extinction could reduce productivity of plants on Earth by half 2Nationwide Children's Hospital involved in expanded access program for treatment of PKU 2
(Date:9/30/2014)... German . , The ... a semiconductor layer. Quantum dots are small structures that spontaneously ... short laser pulse is fired at the photonic crystal, its ... change in the electromagnetic field around it. This change can ... the dot. As soon as the refractive index recovers its ...
(Date:9/30/2014)... Sept. 30, 2014 Pacific Northwest Biotechnology, ... Summary Global Markets Direct,s, ,Pacific Northwest Biotechnology, ... an overview of the Pacific Northwest Biotechnology, LLC,s ... provides comprehensive information on the current therapeutic developmental ... comparative analysis at various stages, therapeutics assessment by ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Over the ... primarily due to rising R&D budgets and increased acceptance ... fast growing pharmaceutical and biotechnology industries are also catalyzing ... laboratory filtration market is expected to grow at a ... is estimated to be worth $2,532.6 million by 2019. ...
(Date:9/30/2014)... 30, 2014 CORD:USE Cord Blood Bank – ... it has entered into an Equity and Exclusive Services ... licensed a series of patented technologies for the isolation of ... applications.  Tianhe is performing Phase I/II clinical trials in ... using Tianhe,s Stem Cell Educator Therapy showing ...
Breaking Biology Technology:Ultrafast remote switching of light emission 2Pacific Northwest Biotechnology, LLC - Product Pipeline Review - 2014 2Pacific Northwest Biotechnology, LLC - Product Pipeline Review - 2014 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 2Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 3Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 4Global Laboratory Filtration Market To See 7.0% CAGR to 2019 Says a Research Report Available at ReportsnReports.com 5CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 4
... Companies Require Most Dramatic ChangesNEW YORK, March 9 ... rising risk, more than 40 percent of executives surveyed ... say that their companies need to institute significant changes ... according to the results of a new white paper ...
... a privately held biotechnology company focused on the discovery ... disease, today announced that Ulrik B. Nielsen has been ... and Edward (Tad) J. Stewart to Senior Vice President ... played critical roles in building Merrimack into ...
... March 9 PURE Bioscience (Nasdaq: ... citrate (SDC) antimicrobial, today announced that John J. ... of Directors. Dr. Carbone fills the vacancy ... February 13, 2009.(Logo: http://www.newscom.com/cgi-bin/prnh/20060119/LATH060LOGO )Michael L. ...
Cached Biology Technology:Increasing Economic and Business Risks Will Transform the Global Life Sciences Industry 2Increasing Economic and Business Risks Will Transform the Global Life Sciences Industry 3Increasing Economic and Business Risks Will Transform the Global Life Sciences Industry 4Increasing Economic and Business Risks Will Transform the Global Life Sciences Industry 5Merrimack Pharmaceuticals Promotes Ulrik B. Nielsen, Ph.D. to Chief Scientific Officer and Edward J. Stewart to Senior Vice President of Business Development 2PURE Bioscience Board Appoints John J. Carbone, MD to Board of Directors 2PURE Bioscience Board Appoints John J. Carbone, MD to Board of Directors 3PURE Bioscience Board Appoints John J. Carbone, MD to Board of Directors 4
...
... With increasing age, the autofluorescent pigment ... many cell types, including neurons. The ... the use of fluorescence microscopy in ... its broad excitation and emission spectra, ...
Purified anti-LAT...
Polyclonal Antibody to AHI1 / Jouberin...
Biology Products: