Navigation Links
How brain pacemakers erase diseased messages

Brain "pacemakers" that have helped ease symptoms in people with Parkinson's disease and other movement disorders seem to work by drowning out the electrical signals of their diseased brains.

Despite the clinical success of the devices, which have been approved by the Food and Drug Administration and can be found in the heads of about 30,000 Americans, the mechanisms by which deep brain stimulation alleviates disease symptoms aren't well understood.

Biomedical engineers at Duke University's Pratt School of Engineering have found that stimulation administered by rapid-fire electrical pulses deep in the brain produces what they call an "informational lesion." By relaying a repetitious and therefore meaningless message, constant pulses overwhelm the erratic bursts of brain activity characteristic of disease.

"Periodic bursts in the brains of people with tremor -- which might follow a pattern such as 'pop-pop-pop, silence, pop-pop-pop, silence' -- propagate pathological information within brain circuits," said Warren Grill, the study's lead investigator and an associate professor of biomedical engineering. "If you replace that instead with a constant 'pop-pop-pop-pop-pop-pop,' you've erased that pathological information."

Grill said the high-frequency deep brain stimulation acts like a surgical lesion, another acceptable treatment for severe tremor disorders and epilepsies. But the electronic device has the advantage of being adjustable or reversible.

The researchers' report appears in a special June 2007 issue of the journal IEEE Transactions on Neural Systems and Rehabilitation Engineering, edited in part by Grill. The study was conducted by a team that included Alexis Kuncel, a doctoral student in biomedical engineering at Duke, and Scott Cooper, a neurologist at the Cleveland Clinic, with support from the National Institutes of Health.

The FDA approved the use of deep brain stimulation for Parkinson's disea
'"/>

Source:Duke University


Page: 1 2 3

Related biology news :

1. Controversial drug shown to act on brain protein to cut alcohol use
2. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
3. Mouse brain tumors mimic those in human genetic disorder
4. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
5. First atlas of key brain genes could speed research on cancer, neurological diseases
6. NYU study reveals how brains immune system fights viral encephalitis
7. Stem cells from brain transformed to produce insulin at Stanford
8. Birds brains reveal source of songs
9. Loves all in the brain: fMRI study shows strong, lateralized reward, not sex, drive
10. Revolutionary nanotechnology illuminates brain cells at work
11. A puzzle piece found in unraveling the wiring of the brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: How brain pacemakers erase diseased messages

(Date:6/17/2015)... 17, 2015  Crossmatch™, a leading provider of ... U.are.U ® 4500 fingerprint readers have been ... Inc., a San Jose, CA ... security, improve accountability and reduce fraud at the ... identity confirmation for employee sign in and transaction ...
(Date:6/16/2015)... June 16, 2015 Fingerprint Cards has ... sensors in the company,s portfolio from one of its module ... to mainly take place during the third quarter 2015. The ... Asia . Jörgen Lantto, CEO of FPC, ... the   growing interest from smartphone OEMs in integrating touch ...
(Date:6/15/2015)... A new report [ 1 ] ... consumers using mobile banking applications want their mobile devices to ... instead of having to prove who they are with passwords ...   -   The Fusion of Financial Services, Mobile and ... channel used by Gen X and Gen Y to access ...
Breaking Biology News(10 mins):Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3FPC Receives Order for Touch Fingerprint Sensors of 375 MSEK 2One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 2One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 4
... (MERS) is prevalent in camels throughout Saudi Arabia and has ... study to be published on February 25 in mBio ... Microbiology. "Our study shows the MERS coronavirus (MERS-CoV) is ... University, New York. "Adult camels were more likely to have ...
... Scientists are revealing how microbes living on floating ... and the potential harm they pose to invertebrates, humans ... delves deeper into the largely unexplored world of the ... on ocean plastic that was first discovered last year. ...
... , AMHERST, Mass. Like a kindergarten or a busy ... are common gathering places where pollinators such as bees and ... might be as benign as the sniffles or as debilitating ... how pathogens of pollinators are transmitted at flowers," postdoctoral researcher ...
Cached Biology News:MERS virus widespread in Saudi Arabian camels 2AGU: Uncovering the secret world of the Plastisphere 2As hubs for bees and pollinators, flowers may be crucial in disease transmission 2
(Date:6/30/2015)... Clara CA (PRWEB) , ... June 30, 2015 ... ... microscopy (AFM) is hosting a webinar to provide advanced scientific research into new ... science, bio science and energy. Touted as 'the wonder material of the ...
(Date:6/30/2015)... ... June 30, 2015 , ... uBiome and OpenBiome ... on mechanics of fecal microbiota transplantation in C. difficile patients. , SAN FRANCISCO, ... patients undergoing fecal microbiota transplantation (FMT) as a treatment for Clostridium difficile infections ...
(Date:6/30/2015)... ... June 30, 2015 , ... Matrix Marketing Group, ... it has hired Gem Swartz to head up its account management department as vice ... Both Gem and Amanda bring senior account management and delivery expertise to the growing ...
(Date:6/30/2015)...  The Dr. Samadi Prostate Cancer Center in ... suite of new genetic testing methods for men with an ... cancer. Dr. Samadi,s Prostate Cancer Center ... the risk and optimizing the diagnosis of prostate cancer, both ... now offer these revolutionary genetic tests to men with an ...
Breaking Biology Technology:How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 2How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 3How Graphene–based Nanomaterials and Films Revolutionize Science Explained in July 9 Webinar Hosted by Park Systems 4uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 3Matrix Marketing Group Expands Client Services Team 2New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 2New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 3New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 4New Revolutionary Genetic Testing for Prostate Cancer Offered at Dr. Samadi's Prostate Cancer Center 5
... Pitney Bowes, a mail and document management solutions company ... Firstlogic in a $50.3 million buyout of La ... , ,Company representatives said employment ramifications of the deal ... ,The transaction is expected to close in the third ...
... -- Esker Software has added fax reception to its pay-per-use, ... be able to receive faxes directly into their inboxes. , ... of the most common desktop applications to automate faxing of ... , ,"By adding the flexibility of inbound faxing, we have ...
... Startup entrepreneurs throughout the Upper Midwest will have the chance ... the Wisconsin Early Stage Symposium . , ,The event, ... run from Oct. 19-20. It is being organized by the ... Network and the Wisconsin Entrepreneurs' Network. , ,"When you think ...
Cached Biology Technology:Pitney Bowes to acquire Firstlogic 2Conference will focus on financing of early-stage ventures 2Conference will focus on financing of early-stage ventures 3
...
cysteine and glycine-rich protein 2,...
... agent and DNA-topoisomersae II inhibitor (IC50 = 59.2 ... C 29 H 32 O 13 ... Store at: RT ... Soluble to 100 mM ...
HSPBP1 Antibody...
Biology Products: