Navigation Links
How blood flow dictates gene expression

Researchers at the University of Pennsylvania School of Medicine have pinpointed a key regulatory protein that translates blood flow into gene expression. The investigators showed that in a model of mouse embryonic development a transcription factor called Klf2, which resides in cells that line blood vessels, is activated by rapid, pulsed blood flow, as reported in the December issue of Developmental Cell. Understanding Klf2's role in blood vessel and muscle biology could help with fighting atherosclerosis.

"We always knew that there had to be this line of communication from the vessel lining, or endothelium, to the smooth muscles, which never sees a blood cell," says senior author Mark Kahn, MD, Associate Professor of Medicine. "That's where Klf2 fits: This is the first time, at a molecular level, that this chain has been demonstrated in an animal."

Swirling eddies of blood form when vessels branch, much like when a river divides. Atherosclerosis typically forms at these sites of so-called disturbed flow as opposed to regions of rapid blood flow through the main vessels. This relationship between atherosclerosis and flow has been known for decades. More recently, tissue- culture studies have shown that Klf2 is activated by increased blood flow, or "fluid sheer stress."

Indeed, in this study Kahn; first author John S. Lee, MD, PhD, Instructor in the Department of Medicine; and colleagues show that the expression of Klf2 in a developing mouse embryo mirrors events in previous tissue-culture studies. They found that Klf2 is expressed on the high-flow side of developing mitral and aortic valves in the heart of a 14-day-old embryo.

The researchers surmise that the mechanical stimulus of blood flowing in a vessel leads to the upregulation of Klf2, which either activates or represses genes that control smooth muscle tone, that is the caliber of the vessel. (Tone is governed by how much a muscle contracts or relaxes.) The
'"/>

Source:University of Pennsylvania School of Medicine


Page: 1 2

Related biology news :

1. White blood cell waste disposal system plays critical regulatory role
2. Epstein-Barr virus protein crucial to its role in blood cancers
3. New insight into regulation of blood stem cells
4. Nano-bumps could help repair clogged blood vessels
5. First technology to remove prions that cause vCJD from blood launched
6. Breakthrough isolating embryo-quality stem cells from blood
7. Thai spice helps cut blood sugar swings
8. Study shows humans have ability to track odors, much like bloodhounds
9. Mad cow proteins successfully detected in blood
10. Unexpected lock and key mechanism found for the assembly of tumor blood vessels
11. Redesigned protein accelerates blood clotting
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: How blood flow dictates gene expression

(Date:5/27/2015)... , May 27, 2015   ... medication safety systems and image documentation solutions ... of comprehensive, technologically-advanced automation solutions, is pleased ... integration. The Codonics® Safe Label System® (SLS), ... in conjunction with the Omnicell Anesthesia Workstation, ...
(Date:5/22/2015)... According to a new market research report ... by Software (Middleware, Databases), by Hardware (Cameras, Integrated Devices), ... - Global Forecast to 2020", published by MarketsandMarkets, Facial ... to $6.19 Billion by 2020, at a CAGR of ... and   43 Figures spread through 140 Pages and ...
(Date:5/20/2015)... OXFORD, Conn. , May 20, 2015 ... "Company") announces that its wholly owned subsidiary, 3D-ID LLC, ... contractor under Team Battelle for the biometrics technology portion ... Unrestricted Suite Contract from the Department of the Army. ... facial recognition products developed for government, law enforcement and ...
Breaking Biology News(10 mins):Codonics and Omnicell Expand Partnership 2Codonics and Omnicell Expand Partnership 3Codonics and Omnicell Expand Partnership 4Facial Recognition Market Worth $6.19 Billion by 2020 2Facial Recognition Market Worth $6.19 Billion by 2020 3NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3
... Francisco have launched a groundbreaking study to determine whether ... the most common congenital chest deformity, in the same ... chest, which is known medically as pectus excavatum, is ... to the breastbone. The deformed cartilage pulls the breastbone ...
... recurrent cancer of the central nervous system that occurs primarily ... a clinical trial at the University of California, San Francisco. ... is always fatal. Findings from a group of 12 ... effective in stimulating the patient’s immune system to attack ...
... that chimpanzees from West Africa were cracking nuts with ... years ago. The result suggests chimpanzees developed this behaviour ... was a trait inherited from our common ancestor. Julio ... the Noulo site in Cote d'Ivoire, the only known ...
Cached Biology News:Study to explore using magnets to correct 'sunken chest' 2Study to explore using magnets to correct 'sunken chest' 3UCSF brain tumor vaccine trial shows promising results 2UCSF brain tumor vaccine trial shows promising results 3The chimpanzee stone age 2
(Date:6/3/2015)... Typical racks for laboratory freezers are generally ... often taking up unnecessary room in already crowded freezers. ... Box Freezer Racks offer a customizable storage solution ... boxes and freezers. , “These racks are perfect ... multiple people because users can configure freezer space to ...
(Date:6/3/2015)... Green Earth Energy has restructured their ... the RCBC Waste to Energy system. Paul Douglas ... family business, http://www.greenearthwaste.com which has been operating ... recycling to their waste collection services in 2012 and ... Fortune 500 companies with manufacturing plants in West Tennessee. ...
(Date:6/3/2015)... REYKJAVIK, Iceland , June 3, 2015   ... genome to improve health worldwide, today announced that it ... to provide clinical interpretation of the whole genome sequences ... of the first phase of the 100,000 Genomes Project ... WuXi NextCODE will deploy its unique database ...
(Date:6/3/2015)... June 03, 2015 Global Stem ... Inc. have announced plans to conduct Romania’s first ever ... Through an alliance with Miami-based Stem Cell Training, Inc., ... the Adipose and Bone Marrow Stem Cell Training Course ... reconstructive plastic surgery specialist practicing in Bucharest and Tel ...
Breaking Biology Technology:Freezer Space Can Now Be Configured Your Way with New Modular Freezer Racks 2WuXi NextCODE Wins Genomics England Clinical Interpretation Tender in both Rare Disease and Cancer 2Global Stem Cells Group Announces First Stem Cell Training Course to Take Place in Romania 2Global Stem Cells Group Announces First Stem Cell Training Course to Take Place in Romania 3
... Jersey, October 29, Rosetta Genomics Ltd. (Nasdaq: ROSG ... announced today its,management will present at Oppenheimer 19th ... the Waldorf-Astoria Hotel in New York,City., About ... occurring, small,RNAs that act as master regulators and ...
... /Xinhua-PRNewswire/ -- Sinovac Biotech Ltd. (Amex:,SVA), a vaccine-focused ... scheduled to present at two upcoming investor conferences, ... York City and the,Credit Suisse Asian Healthcare Conference ... Financial Manager, is scheduled to present on,Tuesday, November ...
... Osteotech, Inc.,(Nasdaq: OSTE ), a leader ... healing, announced today that it has received 510(k) ... ("FDA") for its next,generation grafting material. Osteotech received ... substitute, and as a bone void filler, for ...
Cached Biology Technology:Rosetta Genomics to Present at Oppenheimer's 19th Annual Healthcare Conference 2Rosetta Genomics to Present at Oppenheimer's 19th Annual Healthcare Conference 3Sinovac to Participate in Two Upcoming Investor Conferences 2Osteotech Receives FDA Clearance for its Next Generation Grafting Material 2