Navigation Links
How HIV 'exhausts' killer T cells

American and South African scientists working at the epicenter of the AIDS epidemic in South Africa have discovered how the human immunodeficiency virus (HIV) "exhausts" killer T cells that would otherwise attack the virus. The researchers found that HIV can simply "turn off" fully functional T cells by flipping a molecular switch on the cells. In test tube studies, however, the scientists showed that they could reinvigorate the killer T cells by blocking that inhibitory switch, which is called programmed death-1 (PD-1).

The study's senior author, Bruce Walker, a Howard Hughes Medical Institute researcher at Massachusetts General Hospital, said that clinical testing of drugs that block the PD-1 switch could begin very soon, since such drugs exist already. However, he cautioned that these kinds of drugs could cause serious side effects, including autoimmune reactions that trigger the immune system to attack the body. Walker added that the researchers' findings will also likely have application in understanding other chronic viral diseases.

The findings by Walker and his colleagues were published in an advance online publication on August 20, 2006, by the journal Nature. Walker is also at the Partners AIDS Research Center and Harvard Medical School. Other co-authors were from the University of KwaZulu Natal in South Africa, Oxford University, Dana-Farber Cancer Institute of Harvard Medical School, Emory University School of Medicine, and The Wistar Institute.

"It's long been known that people with HIV infection have a lot of HIV-specific immune cells that one would think would be actively combating the virus," said Walker. "But a major puzzle has been that even in late-stage illness, when one can still measure great numbers of these immune cells, they don't seem to be controlling the virus at all."

An important clue to why killer T cells stop functioning after infection came from ear
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3 4

Related biology news :

1. Genetically modified natural killer immune cells attack, kill leukemia cells
2. Thinking the pain away? Study shows the brains painkillers may cause placebo effect
3. Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack
4. Can two killers make a cure?
5. Secret sex life of killer fungus?
6. Brazilians sequence genes of pig and poultry killers
7. Russian surrogate alcohols are a killer
8. Pain killer fights breast cancer by targeting key enzyme
9. Newly discovered killer cell fights cancer
10. Three-in-one virus killer prevents common, often fatal infections
11. Hope for major advance in fighting world killer disease
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: How HIV exhausts killer cells

(Date:9/18/2014)... 2014Many Americans across racial and ethnic groups describe ... on their day-to-day life, more so than other ... speech (57% of African-Americans, 49% of non-Hispanic whites, ... asked which disease or ailment is the worst ... among African-Americans followed by AIDS/HIV. Hispanics and ...
(Date:9/18/2014)... from several disciplines will be celebrated tonight at the ... in improving the health of premature infants and in ... The researchers, whose work was supported by the National ... former Atomic Energy Commission, will be honored at a ... A bipartisan group of Members of Congress will be ...
(Date:9/18/2014)... comprise all spheres of our planet. Manifold interactions ... and perturbations that resulted in increases of the ... climate changes which influence the complex biogeochemical processes ... these feedback mechanisms has become an important new ... past three decades. , In parallel, a novel ...
Breaking Biology News(10 mins):Americans rate losing eyesight as having greatest impact on their lives 2Americans rate losing eyesight as having greatest impact on their lives 33rd annual Golden Goose award ceremony honors 8 researchers; Unusual work had big results 2Greenhouse gas research enters a new era 2
... LOUIS, MO, September 19, 2011 Dr. Martin Fregene, ... Plant Science Center has been tasked with leading the ... Akin Adesina, the Honourable Minister for Agriculture and Natural ... and will remain a co-Principal Investigator of BC Plus ...
... ,URBANA A University of Illinois study reports a ... patients who have developed resistance to chemotherapy. U of ... peptide lunasin binds to a specific receptor in highly metastatic ... "When lunasin was used in combination with the chemotherapy ...
... 2011) Dietary salt intake and obesity are two important ... packs its own punch, but when combined, they deliver more ... their individual contributions. Discovering the molecular mechanisms behind this lethal ... by Toshiro Fujita, MD, professor and chairman of the Department ...
Cached Biology News:Danforth Center scientist recruited to spearhead cassava green revolution for Nigeria 2Danforth Center scientist recruited to spearhead cassava green revolution for Nigeria 3Soy peptide + chemo drug block colon cancer's spread to liver 2Abnormal activation of a protein may explain deadly link between high salt intake and obesity 2
(Date:9/20/2014)... September 20, 2014 MediVet America ... perform a groundbreaking surgery at the specialized Wolvega Horse ... superficial digital flexor tendon was ruptured 90% and her ... injury is a death sentence for a horse. , ... stem cell treatments . This revolutionary regenerative option ...
(Date:9/19/2014)... 2014 Follow us on ... revolutionize the world has attracted diverse players including ... start-ups. The early years of nanotechnology development was ... to the high risks involved, which deterred private ... this evolving technology have been growing over the ...
(Date:9/19/2014)... SPRINGS, Florida , September 19, 2014 ... companies release latest developments, patents and results of studies ... GNSZ), Eli Lilly and Company (NYSE: LLY ... Celgene Corporation (NASDAQ: CELG ) and Arena ... GNSZ), a leader in developing prodrug therapeutics for the ...
(Date:9/19/2014)... -- The new , Healthcare and Life Sciences ... on PharmaBoardroom.com for free download , looks ... Spanish economy in 2009, and the austerity measures that followed, ... in times of trouble. "Despite the crisis, ... market, and the general conditions to invest are favorable to ...
Breaking Biology Technology:World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 2World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 3Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 3Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 4Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 2Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 3Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 4Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 5Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 6Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 7PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3
... ROCHESTER, N.Y., July 14 Bio-Optronics, Inc., a leader ... an intelligent, hosted software solution that can simultaneously handle the ... build the best staff schedules. , , ... process. , , Bio-Optronics ...
... VIENNA, Austria, July 14 Elan Corporation, plc (NYSE: ... presented information this week at the Alzheimer Association 2009 International Conference ... presentation about the growing burden of care and costs associated with ... sheds light on the impact of AD, which, as the population ...
... Kelly ... topic of "Capitalizing on Trends in Negotiation, Contracts, and Risk and Reward." Discussion ... providers such as clinical research organizations. , ... Washington, DC (PRWEB) July 14, 2009 -- ClearTrial ( www.cleartrial.com ...
Cached Biology Technology:NEW Momentum(TM) Physician and Staff Scheduling Software for Imaging Centers, OB/GYN, and Other Specialty Practices Improves Productivity and Equity in Scheduling 2Studies Presented at International Conference on Alzheimer's Disease Reveal Substantial Economic Costs and Caregiver Burden Associated with Alzheimer's Disease 2Studies Presented at International Conference on Alzheimer's Disease Reveal Substantial Economic Costs and Caregiver Burden Associated with Alzheimer's Disease 3Studies Presented at International Conference on Alzheimer's Disease Reveal Substantial Economic Costs and Caregiver Burden Associated with Alzheimer's Disease 4Studies Presented at International Conference on Alzheimer's Disease Reveal Substantial Economic Costs and Caregiver Burden Associated with Alzheimer's Disease 5Studies Presented at International Conference on Alzheimer's Disease Reveal Substantial Economic Costs and Caregiver Burden Associated with Alzheimer's Disease 6Studies Presented at International Conference on Alzheimer's Disease Reveal Substantial Economic Costs and Caregiver Burden Associated with Alzheimer's Disease 7ClearTrial Selected to Lead Executive Panel from Pharmaceutical and Service Provider Companies at ExL Conference 2ClearTrial Selected to Lead Executive Panel from Pharmaceutical and Service Provider Companies at ExL Conference 3
... DX's sensitivity of DNA detection has been improved. ... an agarose gel can be detected > 20 ... be purified by organic solvent extraction or with ... worked well.) DNA excised from agarose gel ...
... The RapidTrace SPE Workstation is a ... phase extraction platform. Utilizing 1ml or 3ml ... process up to 100 samples in less ... be loaded with 10 cartridges, and up ...
... form of cell suicide, which follows a ... of this process is a cascade of ... participate in a series of reactions that ... and result in the cleavage of protein ...
... manufactured for DNA purification from agarose gels ... light. The Purification of DNA from an ... work. The conventional method of visualizing DNA ... light damages DNA and significantly decreases cloning ...
Biology Products: