Navigation Links
How A Latent Virus Eludes Immune Defenses

For a virus to survive, it must elude the ever vigilant immune sentinels of its host. A latent virus can escape immune detection if it resides in nondividing cells and doesn’t produce any proteins. No viral proteins means no red flags for immune cells. If the virus targets one of the many cell types that rarely divide, it’s relatively safe while latent. But some viruses, like the gamma-herpesvirus, infect B cells of the immune system, which occasionally divide. The gamma-herpesvirus genome persists as circular pieces of DNA called episomes. When an infected B cell divides, the latent gamma-herpes virus episome must replicate and segregate into daughter cells along with the cell’s genome. Viral replication and segregation requires the services of a protein called the episome maintenance protein—a potentially recognizable target for immune cells.

Gamma-herpesviruses, including Epstein-Barr virus (EBV) and Kaposi’s sarcoma–associated herpesvirus (KSHV), can induce uncontrolled lymphocyte (immune cell) proliferation and result in lymphoma, Hodgkin’s disease, and Kaposi’s sarcoma. These diseases arise from the persistent latent infections that take hold after initial infections are controlled by immune defenses. The episome maintenance protein produced by EBV, called EBNA-1, harbors an amino acid element in its epitope—the region that binds to a T cell and triggers an immune response—that helps the viral protein evade the killer T cells that could destroy it. Lab studies show that the amino acid element limits EBNA-1’s interaction with T cells by inhibiting synthesis and, to a lesser degree, degradation of the protein. How this evasive action works or helps the virus in a living organism is not entirely clear. But if T cells aren’t presented with bits of viral protein, they have no way of knowing the virus is present.

In a new study, Neil Bennett, Janet May, and Philip Stevenson explore this question by studying virus–host interactions in mice infected wit
'"/>

Source:PLoS Biology


Page: 1 2 3

Related biology news :

1. Latent memory of cells comes to life
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Study: Soap And Water Work Best In Ridding Hands Of Disease Viruses
4. Mayo Clinic Researchers Create Obedient Virus; First Step To Use Measles Virus Against Cancer
5. Norovirus, AIDS vaccine and Hepatitis Virus
6. Virus-host interactions at sea effect global photosynthesis
7. Secrets to antibodys success against West Nile Virus surprise scientists
8. “Hitchhiking?Viruses as Cancer Drug Delivery System
9. Virus uses tiny RNA to evade the immune system
10. Virus chip detects new virus in prostate tumors
11. Virus has catastrophic affect on red squirrels, research shows
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: How Latent Virus Eludes Immune Defenses

(Date:12/22/2014)... Research and Markets ( http://www.researchandmarkets.com/research/fx4bg3/the_global ) ... Global Watermarking and Fingerprinting Markets" report to ... This insight provides an overview ... markets. Watermarking aims to control and monitor piracy ...
(Date:12/19/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has ... America Perimeter Security Systems Market" report to their offering. ... North American perimeter security market is estimated to grow at ... U.S. market holds a larger share in this market, ...
(Date:12/17/2014)... 15, 2014 Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ... Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology ... http://photos.prnewswire.com/prnh/20130307/600769 Based on a ... introduces for the first time a fingerprint sensor in ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2
... Prof. Nathan Nelson of Tel Aviv University,s Department ... has been awarded the 2012 Israel Prize in the ... in Jerusalem on the eve of Israel,s Independence Day ... molecular biology, Prof. Nelson is internationally renowned for his ...
... soon become a thing of the past. Instead, with ... painless injection four times a year would be enough. ... and is delivered by an injection into the outer layer ... The nanocarrier will then slowly release the drug over ...
... receive this year,s Charles Rodolphe Brupbacher Prize for Cancer ... of chronic inflammation in the development of tumors. The ... considered one of the highest accolades for cancer researchers ... Thursday in the framework of an international symposium on ...
Cached Biology News:NTU launches new centre to develop new eye-deas for occular therapeutics 2NTU launches new centre to develop new eye-deas for occular therapeutics 3Brupbacher Prize goes to cancer researcher Michael Karin 2
(Date:1/22/2015)... 2015 Selexis SA, a serial innovation ... Banks (RCBs) used for drug discovery to commercial manufacturing, ... include Next-Generation Sequencing (NGS) data packages. The ... manufacturing by ensuring the integrity of the gene, validation ...
(Date:1/22/2015)... , Jan. 22, 2015   Cypher Genomics, Inc., ... Inc. (NASDAQ: SQNM ), the leading ... for next generation noninvasive prenatal tests (NIPT). Through ... technology, called Mantis™, to advance analysis of clinically-relevant ...
(Date:1/22/2015)... 22, 2015  Derma Sciences, Inc. (Nasdaq: ... advanced wound care, announces that AMNIOEXCEL® and AMNIOMATRIX®, ... added to the Premier, Inc. Regenerative Skin Grafting ... the AMNIOEXCEL® and AMNIOMATRIX® product lines, which continue ...
(Date:12/24/2014)... YORK , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. ... critical areas, announced the closing of an underwritten public offering ... up to an aggregate 3,500,000 shares of common stock, at ... warrant.  The warrants have a per share exercise price of ...
Breaking Biology Technology:Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3
... Embryo Donation International (EDI), one of the few, ... officially opened today to provide cost-effective embryo donation options ... family.     (Logo: http://photos.prnewswire.com/prnh/20110405/FL76876LOGO) ... number of frozen embryos abandoned or discarded ...
... 2011 Champions Oncology, Inc. (OTC: CSBR) ("the Company", formerly ... the private placement of 12.5 million shares of its common ... gross proceeds to the company of $9.4 million. ... in: Sales resources dedicated to growing its ...
... Caliper Life Sciences, Inc. (NASDAQ: CALP ), ... discovery and life-sciences research, today announced that its Caliper ... research collaboration with Denver-based Catholic Health Initiatives (CHI), one ... health care system,s Center for Translational Research (CTR), which ...
Cached Biology Technology:A New Company Is Born - Embryo Donation International 2Champions Oncology (formerly Champions Biotechnology) Completes $9.4 Million Financing 2Champions Oncology (formerly Champions Biotechnology) Completes $9.4 Million Financing 3Caliper Announces New Oncology Research Collaboration 2Caliper Announces New Oncology Research Collaboration 3
... reports the data from any one of IITC ... recorder. The final data is sent from the ... is automatic for Systolic, Mean, Heart Rate while ... is always in the position to override the ...
... Custom DNA microarrays designed for your specific ... powerful Paraflo microfluidic synthesis platform. Thousands of ... and LC Sciences can provide assistance with ... as part of our comprehensive Custom DNA ...
... RNA aptamer screening and binding optimization and ... microfluidic on-chip synthesis platform. These microarrays are ... Aptamer Microarray Service. Probe Content ... contains greater than 1500 known aptamer sequences. ...
... for RNA aptamer screening and binding optimization ... Paraflo microfluidic on-chip synthesis platform. Thousands of ... on-chip and LC Sciences can provide assistance ... available as part of our comprehensive DNA/RNA ...
Biology Products: