Navigation Links
Horse antibodies against the bird flu virus H5N1 are effective as treatment in mice

Antibodies against the bird flu virus H5N1, derived from horses, prevent mice infected with H5N1 from dying from the virus.

A study published today in the open access journal Respiratory Research (http://respiratory-research.com) reveals that a dose of 100 µg of horse anti-serum effectively protects infected mice. These results suggest that anti-H5N1 antibodies developed in horses could potentially be used to prevent death from H5N1 influenza, or as early treatment for the disease, in humans.

Jiahai Lu from Sun Yat-Sen University in Guangzhou, China and colleagues from other institutions in China infected dog kidney cells in vitro with a lethal dose of H5N1 and simultaneously exposed the cells to horse antibodies against H5N1. Lu et al.'s results show that horse antibodies to H5N1 protected cells against H5N1 in vitro ?the cells simultaneously infected with H5N1 and exposed to horse antibodies did not die.

Lu et al. then injected horse antibodies into 40 mice that had been infected with a lethal dose of H5N1 24 hours earlier. The authors also injected horse serum without H5N1 antibodies into a group of mice that acted as controls.

The authors found that 50µg of antibody protected 70% of the mice against death by H5N1 and 100 µg of antibody protected 100% of the mice. The mice in the control group died nine hours after receiving the normal horse serum.


'"/>

Source:BioMed Central


Page: 1

Related biology news :

1. Horseshoe crab decline threatens shorebird species
2. Trojan Horse agent halts bone metastasis in mice
3. Horse genome assembled
4. First production of human monoclonal antibodies in chicken eggs published in Nature Biotechnology
5. Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned
6. Mice studies illustrate potential of chimp/human antibodies to protect against smallpox
7. GlycoFi announces the first production of antibodies with human glycosylation in yeast
8. Data published in PNAS show antibodies can be made 10 times more toxic to cancer cells
9. Report calls for improved monoclonal antibodies against solid tumors
10. Cheaper, better disease treatments expected from faster approach to developing antibodies
11. Researchers from the University of Navarra analyze new kinds of cancer-fighting antibodies
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/20/2016)...  VoiceIt is excited to announce its new ... By working together, VoiceIt and VoicePass will offer ... take slightly different approaches to voice biometrics, collaboration ... usability. Both ... "This marketing and technology partnership allows ...
(Date:5/3/2016)...  Neurotechnology, a provider of high-precision biometric identification ... Identification System (ABIS) , a complete system for ... can process multiple complex biometric transactions with high ... face or iris biometrics. It leverages the core ... MegaMatcher Accelerator , which have been used in ...
(Date:4/26/2016)... 27, 2016 Research and ... Biometrics Market 2016-2020"  report to their offering.  , ... The analysts forecast the global multimodal biometrics ... during the period 2016-2020.  Multimodal biometrics ... such as the healthcare, BFSI, transportation, automotive, and ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , June 27, 2016  Global demand for ... percent through 2020 to $7.2 billion.  This market ... beverages, cleaning products, biofuel production, animal feed, and ... diagnostics, and biocatalysts). Food and beverages will remain ... by increasing consumption of products containing enzymes in ...
(Date:6/27/2016)... , ... June 27, 2016 , ... ... bring innovative medical technologies, services and solutions to the healthcare market. The company's ... of various distribution, manufacturing, sales and marketing strategies that are necessary to help ...
(Date:6/24/2016)... , June 24, 2016 Epic Sciences ... detects cancers susceptible to PARP inhibitors by targeting ... cells (CTCs). The new test has already been ... in multiple cancer types. Over 230 ... damage response pathways, including PARP, ATM, ATR, DNA-PK ...
(Date:6/23/2016)... 2016   Boston Biomedical , an industry ... to target cancer stemness pathways, announced that its ... Drug Designation from the U.S. Food and Drug ... including gastroesophageal junction (GEJ) cancer. Napabucasin is an ... cancer stemness pathways by targeting STAT3, and is ...
Breaking Biology Technology: