Navigation Links
Hormone helps mice 'hibernate,' survive starvation

e molecular impact of PPAR-alpha in mice, the researchers found that it stimulates production of FGF21, a member of a hormone family that has been shown to lower blood glucose levels in diabetic and obese mice.

FGF21, in turn, stimulates the use of stored fats as energy and causes torpor. In properly fed mice, FGF21 is not normally active; however, when the researchers introduced FGF21 into these mice, the animals’ metabolism changed.

“When mice were given this hormone, their metabolism appeared as if they were starved, even after they had just eaten,” said Dr. Kliewer.

Because limiting food consumption is known to have a range of beneficial effects, such as lowering blood pressure, cholesterol and glucose levels in the blood, Dr. Kliewer is interested in understanding how FGF21 impacts these processes.

“We want to see if we can get some benefits of eating less without actually eating less,” he said.

Manipulating the PPAR-alpha-FGF21 signaling pathway might ultimately prove to be a vital part of the ongoing search for new therapies for human obesity and other metabolic conditions, Dr. Kliewer said.

“Given that the PPAR-alpha receptor already is the target of drugs that work to boost high-density lipoproteins, or the ‘good’ cholesterol, and reduce the amount of fat in the blood, we believe this new pathway may lead to a new class of drugs that will impact many human conditions,” he said.


'"/>

Source:UT Southwestern Medical Center


Page: 1 2

Related biology news :

1. Hormones and growth: The control of body size and developmental growth rate in fruit flies
2. Menopause Symptoms May Come Back After Stopping Menopausal Hormone Therapy
3. Hormone linked to brains cravings for food and other energy sources
4. Jumping gene helps explain immune systems abilities
5. Protein helps regulate the genes of embryonic stem cells
6. Scientists reveal the shape of a protein that helps retroviruses break into cells
7. Thai spice helps cut blood sugar swings
8. Chemists synthesize molecule that helps body battle cancers, malaria
9. Ancient DNA helps clarify the origins of two extinct New World horse species
10. Massey Cancer Center researcher helps to identify a piece of the cancer puzzle
11. Study: Well-known protein helps stem cells become secretory cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Hormone helps mice hibernate survive starvation

(Date:5/17/2013)... May 17, 2013, Shenzhen, China---- Why Tibetan antelope ... Qinghai-Tibetan Plateau? In a collaborative research published in ... BGI, and other institutes provide evidence that some ... adaption to harsh highland environments. The data in ... specific genetic mechanisms and the biology of other ...
(Date:5/17/2013)... international team of scientists using a new X-ray method ... living frog embryo in greater detail than ever before., ... research and the search for new treatments for genetic ... fr Technologie in Germany, in collaboration with the Advanced ... National Laboratory, released the most precise depiction ever of ...
(Date:5/16/2013)... HOUSTON African-American adults living closer to a fast ... than those who lived further away from fast food, ... Anderson Cancer Center, and this association was particularly strong ... new study published online in the American Journal ... residential proximity to a fast food restaurant, and among ...
Breaking Biology News(10 mins):The genome sequence of Tibetan antelope sheds new light on high-altitude adaptation 2New X-ray method shows how frog embryos could help thwart disease 2Body mass index of low income African-Americans linked to proximity of fast food restaurants 2Body mass index of low income African-Americans linked to proximity of fast food restaurants 3
... study by scientists at the University of Miami (UM) Rosenstiel ... to estimate how much of the ocean,s pollution is falling ... understanding of how toxic airborne chemicals, from the burning of ... oceans globally. By measuring Beryllium-7 (7Be) isotope concentrations ...
... PORTLAND, Ore. Researchers at Oregon Health & Science ... for a kind of cancer called sarcoma. In a study ... Cancer Cell , they report that childhood and adult sarcomas ... which these tumors first start. These findings may lead to ...
... of deadly hantavirus outbreaks in people can be predicted months ... in vegetation that boost mouse populations, a University of Utah ... rodent-borne illnesses worldwide. "It,s a way to remotely track ... all the time," says Denise Dearing, professor of biology at ...
Cached Biology News:University of Miami scientists find new way to estimate global rainfall and track ocean pollution 2Scientists discover cell of origin for childhood muscle cancer 2Monitoring killer mice from space 2Monitoring killer mice from space 3Monitoring killer mice from space 4Monitoring killer mice from space 5
(Date:5/16/2013)... 16, 2013 As the weather warms, women ... favorite Spring looks. While most make a statement with fashion, ... women find the warmer weather mixes makeup and sweat to ... the onset of acne during warmer months, Adult Acne ... treatment users the best ways to deter breakouts. , ...
(Date:5/16/2013)... , May 16, 2013 /PRNewswire/ ... market research report is available in ... Competitor Analysis: Therapeutic Proteins ... http://www.reportlinker.com/p01171947/Competitor-Analysis-Therapeutic-Proteins-–-Biosimilars-Biobetters--Biosuperiors.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Biopharmaceutical   ...   The new Competitive ...
(Date:5/16/2013)... Arlington, VA (PRWEB) May 16, 2013 ... for Primary Cells & Stem Cell-Derived Cells: Current and ... low, the number of suppliers in the primary cells ... examines what cell types are used most often, how ... is the market size and anticipated growth rate. ...
(Date:5/16/2013)... Stephen Y. Chou, Founder of Nanonex Corporation, will be ... IEEE Nano 2013 in Beijing, China, on August 5th ... becoming one of the most critical nanofabrication technologies today ... large area, and low cost unmatchable by other nanofabrication ... a broad range of industries, from ICs, nano/micro optical ...
Breaking Biology Technology:Adult Acne Treatment, Probiotic Action Shares New Tips for Women on How to Fight Acne While Wearing Makeup 2Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 2Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 3Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 4Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 5Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 6Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 7Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 8BioInformatics LLC New Market Report – The Market for Primary Cells & Stem Cell-Derived Cells: Current and Future Opportunities (13-004) 2BioInformatics LLC New Market Report – The Market for Primary Cells & Stem Cell-Derived Cells: Current and Future Opportunities (13-004) 3Founder, Prof. Stephen Chou to Give Tutorial on Nanoimprint at IEEE Nano 2013 2
... Inc.,(Nasdaq CM: INSM), a developer of follow-on biologics ... the,Company has retained the services of RBC Capital ... "Insmed,s Board of Directors and senior management ... be utilizing RBC,s experience and,expertise to examine a ...
... (http://www.amdl.com ) AMDL,Inc., (Amex: ADL ) a leading ... the US, announced that the,AMDL-ELISA DR- 70(R) (FDP) test ... the,detection of cancer in clinical practice according to an ... at the University Hospital,in Frankfurt Germany. The results were ...
... 11 Bioheart, Inc.,(Nasdaq: BHRT ) ... and,biologics that help monitor, diagnose and treat ... Doug Owens, Director,Clinical Affairs, will assume responsibility ... investigational MyoCell(R) Therapy clinical,trials from Richard T. ...
Cached Biology Technology:Insmed Retains RBC Capital Markets as Strategic Financial Advisor 2Insmed Retains RBC Capital Markets as Strategic Financial Advisor 3AMDL ELISA DR-70(R) (FDP) is Promising as Effective Cancer Detection Test 2AMDL ELISA DR-70(R) (FDP) is Promising as Effective Cancer Detection Test 3Bioheart, Inc., Announces Management Change 2Bioheart, Inc., Announces Management Change 3
...
Full-length cDNA 5-PRIME end of clone CS0DE013YM09 of Placenta of Homo sapiens (human). [Source:Uniprot/SPTREMBL;Acc:Q86TS7] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
5(S)-HETE-d8 is used as an internal standard for the quantification of 5(S)-HETE by stable isotope dilution mass spectrometry....
... atoms at the 9, 10, 12, and 13 ... internal standard for the quantification of 9(S)-HODE by ... the lipoxygenation of linoleic acid in both plants ... plaques, as an esterified component of membrane phospholipids ...
Biology Products: