Navigation Links
Hormone helps mice 'hibernate,' survive starvation

A key hormone enables starving mice to alter their metabolism and “hibernate” to conserve energy, revealing a novel molecular target for drugs to treat human obesity and metabolic disorders, UT Southwestern Medical Center researchers have found.

The starvation-fighting effects of the hormone, called fibroblast growth factor 21 (FGF21), are described for the first time in a study appearing online today in Cell Metabolism.

FGF21, triggered in starving mice by a specific cellular receptor that controls the use of fat as energy, spurs a metabolic shift to burning stored fats instead of carbohydrates and induces a hibernation-like state of decreased body temperature and physical activity, all geared to promote survival.

“This hormone changes the metabolism and behavior of mice in the face of inadequate nutrition,” said Dr. Steven Kliewer, professor of molecular biology and pharmacology at UT Southwestern and the study’s senior author. “We hope to manipulate this hormone-receptor signaling pathway to craft the next generation of drugs to combat human obesity and other conditions.”

Mammals on the brink of starvation normally shift their main fuel source from carbohydrates to stored fats, promoting survival during foodless periods. Some mammals also enter a hibernation-like state of regulated hypothermia, known as torpor, which conserves energy.

The molecular driver behind this reaction to starvation, however, had been unknown.

To find an answer, UT Southwestern researchers and other scientists examined potential molecular cues and cellular interactions at play during starvation and fasting.

They focused on a nuclear receptor – a protein that turns genes on and off in the body – called peroxisome proliferator-activated receptor alpha, or PPAR-alpha, which is known to control the use of fat as energy. Starving mice without PPAR-alpha become hypoglycemic and quickly die.

In analyzing th
'"/>

Source:UT Southwestern Medical Center


Page: 1 2

Related biology news :

1. Hormones and growth: The control of body size and developmental growth rate in fruit flies
2. Menopause Symptoms May Come Back After Stopping Menopausal Hormone Therapy
3. Hormone linked to brains cravings for food and other energy sources
4. Jumping gene helps explain immune systems abilities
5. Protein helps regulate the genes of embryonic stem cells
6. Scientists reveal the shape of a protein that helps retroviruses break into cells
7. Thai spice helps cut blood sugar swings
8. Chemists synthesize molecule that helps body battle cancers, malaria
9. Ancient DNA helps clarify the origins of two extinct New World horse species
10. Massey Cancer Center researcher helps to identify a piece of the cancer puzzle
11. Study: Well-known protein helps stem cells become secretory cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Hormone helps mice hibernate survive starvation

(Date:7/30/2014)... Embryonic stem cells can develop into a multitude of cells ... development into the specific types of mature cells that make ... , One key seems to be long chains of sugars ... Godula,s group at the University of California, San Diego, has ... sugars, but can be more easily manipulated to direct the ...
(Date:7/30/2014)... published online today in the journal Scientific Reports ... Kodra and Auroop Ganguly found that while global temperature ... temperature extremes. For instance, while each year,s average hottest ... also tend to fall within a wider range of ... being observed. This means that even as overall temperatures ...
(Date:7/29/2014)... In the high-tech world of science, researchers sometimes ... Barbara,s Douglas McCauley did just that to study ... muricatum ) on coral reef ecosystems at two ... Using direct observation, animal tracking and computer simulation, ... Ecology, Evolution and Marine Biology, and his colleagues ...
Breaking Biology News(10 mins):Big data confirms climate extremes are here to stay 2Underwater elephants 2Underwater elephants 3
... at the Oregon National Primate Research Center at Oregon ... gene that appears to control how stem cells become ... implications for the study of Parkinson's disease, brain and ... might be combated by replacing lost or damaged brain ...
... that produce bird feathers have been visualized and analyzed for ... journey that may ultimately shed light on human organ regeneration. ... the journal Nature, was performed by a group of prominent ... University of Southern California. , "What we found is that ...
... team of scientists is proposing that endangered California condors raised ... so that the birds can once again feast on the ... , The researchers from Stanford University and four other institutions ... early condors and their potential prey. Writing in the Nov. ...
Cached Biology News:OHSU discovery sheds light into how stem cells become brain cells 2USC researchers track down the stem cells that create feathers 2USC researchers track down the stem cells that create feathers 3Seal rookeries could provide a reliable food source for endangered California condors, study finds 2Seal rookeries could provide a reliable food source for endangered California condors, study finds 3Seal rookeries could provide a reliable food source for endangered California condors, study finds 4Seal rookeries could provide a reliable food source for endangered California condors, study finds 5
(Date:7/29/2014)... “PharmaSphere: Emerging Biotech Investment Report ... Funding” report provides in-depth analysis of the current ... venture capital segments of the financial industry, bearing ... significant impact on the future of emerging biotechnology ... report identifies regions of the world that are ...
(Date:7/29/2014)... The advanced optical methods and applications for ... a revolution in the neurosciences were the inspiration behind ... SPIE, the international society for optics and photonics ... of the BRAIN Initiative in the United States, and ... vision for and provide examples of the impact that ...
(Date:7/29/2014)... LA JOLLA, Calif. , July 29, 2014 /PRNewswire/ ... therapy-based diagnostic and therapeutic company focused on extending the ... have hired Franz Och , Ph.D., an expert ... Chief Data Scientist. Och comes to HLI from Google ... of Google Translate. He will report directly to HLI ...
(Date:7/29/2014)... ultralight foam of atom-thick sheets can be made to ... at Rice University. , In microscopic images, the ... floors and walls that reinforce each other. The structure ... walls of graphene oxide that self-assemble with the assistance ... say the foam could find use in structural components, ...
Breaking Biology Technology:Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 2Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 3Strategic Trends of Biotech Investment Industry (Private Equity and Venture Capital Funding) in New Report Available at MarketOptimizer.org 4SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 2SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 3SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 4Franz Och, Ph.D., Expert in Machine Learning and Machine Translation, Joins Human Longevity, Inc. as Chief Data Scientist 2Franz Och, Ph.D., Expert in Machine Learning and Machine Translation, Joins Human Longevity, Inc. as Chief Data Scientist 3Tough foam from tiny sheets 2
... , , , LEXINGTON, Mass. ... holding gmbh announced today the launch of the first human cancer ... targeted Next-Generation Sequencing (NGS). The new catalog cancer biochip features 115 ... of cancer by the Wellcome Trust Sanger Institute. , ...
... , , RARITAN, N.J., July 13 ... can accurately predict the prognosis and survival in patients ... published report in the July 10 issue of the ... retrospective study compared how well CTCs and a more ...
... , SAN MARINO, Calif., July 13 ... compounds for HIV/AIDS, autoimmune diseases, and cancer, has retired the majority ... other debt and recently issued new shares. , ... financing through the issuance of shares. This transaction originally was disclosed ...
Cached Biology Technology:First Catalog Cancer Biochip for Sequence Capture Now Available from febit 2Monitoring Circulating Tumor Cells With the CellSearch(R) System Can Predict Prognosis in Metastatic Breast Cancer 2Monitoring Circulating Tumor Cells With the CellSearch(R) System Can Predict Prognosis in Metastatic Breast Cancer 3Monitoring Circulating Tumor Cells With the CellSearch(R) System Can Predict Prognosis in Metastatic Breast Cancer 4Viral Genetics Retires Nearly $3.5 Million Convertible Debt and Provides Updates on Capital Structure and Stock Issuances 2Viral Genetics Retires Nearly $3.5 Million Convertible Debt and Provides Updates on Capital Structure and Stock Issuances 3
...
... Fully adjustable mixing angle, Variable speed, Digital ... a number of different sized tubes, Spillage ... cultures, keeping biological samples in suspension and ... be used in incubators up to 60C ...
... The DNA Engine Opticon 2 real-time PCR ... LEDs for fluorescence excitation (470-505 nm) and ... nm, 540-700 nm). The Opticon 2 system ... cycler, which includes a thermal gradient feature. ...
... Multicolor capability allows detection of SYBR ... channel, and a range of fluorophores in ... VIC, and TAMRA for a multitude ... discrimination. DNA Engine thermal cycler offers precision ...
Biology Products: