Navigation Links
Hopkins scientists link immune response to 'ghost' parasites and severely congested sinuses

left untreated, polyps can lead to severe blockage and recurring infections.

All patients were monitored for a minimum of nine months to see if polyps and their resulting symptoms returned. Ten in the surgery group had their polyps return within six months, while 12 remained symptom free.

The Hopkins team took samples during surgery of the mucous membrane lining the nose, and using real-time polymerase chain reaction tests, analyzed the samples for any genetic differences between the groups.

When researchers initially compared all the nasal tissue samples, they found that half had the gene for AMCase turned on, or expressed, to make the chitinase protein. During follow up, they found that the 10 patients who had their polyps return had exceedingly higher levels of AMCase expression than the other sinusitis patients and controls. Gene expression of another inflammatory protein, called interleukin-13, already known to be high in asthmatics, was also found to be elevated in those with polyps, but the levels of interleukin-13 did not have the same predictive value as the elevated expression of AMCase, researchers say.

Lane adds that future research will have to determine if high genetic expression of AMCase is an underlying cause of inflammation or if AMCase is simply one of many chemicals produced by cells in the nose in response to chronic inflammation.

The next phase of their research, he says, is to look for what triggers the anti-parasite response. However, Lane cautions that this reaction against parasites may come at the expense of the nose's ability to ward off other invaders, such as bacteria, viruses or fungi.

"The epithelial cells lining the nasal and sinus cavities play an important role as first responders of the immune system," he says. "But when they are distracted fighting non-existent parasites, they cannot deal well with the very real microbes continuously coming into the nose."


'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2 3 4

Related biology news :

1. Hopkins AIDS experts issue warning about global efforts to provide drug therapies
2. Hopkins scientists uncover tags that force proteins to cell surface
3. Johns Hopkins flu expert calls for mandatory vaccination of health care workers
4. Whole-genome study at Johns Hopkins reveals a new gene associated with abnormal heart rhythm
5. Hopkins researchers discover genetic switch that turns off an oxygen-poor cells combustion engine
6. Hopkins study suggests commercially available antibiotic may help fight dementia in HIV patients
7. Johns Hopkins lab scientists tame overactive CF protein
8. Hopkins researchers develop new tool to watch real-time chemical activity in cells
9. Hopkins scientists show hallucinogen in mushrooms creates universal mystical experience
10. Hopkins researchers discover how brain protein might control memory
11. Wisconsin scientists grow critical nerve cells
Post Your Comments:
(Date:9/19/2014)... the sake of fairness per se but in order ... Frans de Waal, PhD, and Sarah Brosnan, PhD, co-authors ... is defined as a negative reaction to unequal outcomes. ... , Their conclusion comes after the co-authors reviewed more ... it is the evolution of forestalling partner dissatisfaction with ...
(Date:9/19/2014)... study shows that legume plants regulate their symbiotic ... that are transmitted through the plant structure from ... of bacteria-holding nodules in the roots. This collaborative ... Institute for Basic Biology, the Graduate University for ... Sustainable Resource Science in Japan. , Legumes, ...
(Date:9/18/2014)... A sleep-promoting circuit located deep in the primitive ... Discovered by researchers at Harvard School of Medicine and ... Sciences, this is only the second "sleep node" identified ... both necessary and sufficient to produce deep sleep. , ... the study demonstrates that fully half of all of ...
Breaking Biology News(10 mins):Evolution of responses to (un)fairness 2Evolution of responses to (un)fairness 3For legume plants, a new route from shoot to root 2No sedative necessary: Scientists discover new 'sleep node' in the brain 2
... number of rivers and lakes are being invaded by exotic ... Such species represent a threat to native species, as they ... the case of the mudsnail Potamopyrgus antipodarum ... and has spread throughout rivers, lakes or streams in Europe, ...
... found that silicone foul release coatings may be an important ... water and hydropower infrastructure. Allen D. Skaja, Ph.D., PCS, of ... metal alloys over three years at Parker Dam on the ... to reduce the rate of mussel settlement, and any attached ...
... Calif. ( www.ucr.edu ) Research by Nosang ... Riverside, Bourns College of Engineering, has enabled a ... that can detect small quantities of harmful airborne ... Economy Corporation company, has completed the prototype which ...
Cached Biology News:Survival without water: A key trait of an aquatic invader to spread 2'Electronic nose' prototype developed 2
(Date:9/20/2014)... (PRWEB) September 20, 2014 MediVet ... to perform a groundbreaking surgery at the specialized Wolvega ... mare's superficial digital flexor tendon was ruptured 90% and ... of injury is a death sentence for a horse. ... stem cell treatments . This revolutionary regenerative ...
(Date:9/19/2014)... to disease risks, the biological characteristics people care most ... for heightthe textbook example of a complex traitattributes like ... multiple genetic and environmental influences, making it challenging to ... geneticists typically mate two individuals that differ in key ... then study their descendents, looking for genes that tend ...
(Date:9/19/2014)... Chips that use light, rather than electricity, to ... and energy efficiency is a growing concern as ... chief components of optical circuits light emitters, ... to build. One promising light source for optical ... optical properties when deposited as a single, atom-thick ...
(Date:9/19/2014)... YORK , Sept. 19, 2014  An entire ... forms of inherited neuropathies – Charcot-Marie-Tooth disease (CMT) – ... and legs, causing extreme muscle atrophy, weakness, and foot ... the US and millions worldwide. CMT is a progressive ... of their legs, requiring mobility devices such as leg ...
Breaking Biology Technology:World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 2World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 3Want to link genes to complex traits? Start with more diversity 2Toward optical chips 2Toward optical chips 3September is Charcot-Marie-Tooth (CMT) Awareness Month - Scheduled events, activities and important partnerships announced throughout the month! 2
... 15, 2006, the Supreme Court in eBay Inc. v. ... proves infringement should be granted an injunction must be ... (1) irreparable injury; (2) inadequacy of remedies at law; ... The Court rejected the Federal Circuit's approach that an ...
... encounter, we reviewed the list of the leading Big Pharma companies of ... some of the leading pharmaceuticals products and deals of 2005. , ... Product/Company Disease Area ... Lipitor (Pfizer) Cholesterol Reduction $12.9 +6% ...
... Inc., a developer of protein chip technologies, has ... the National Institutes of Health to develop a test ... ,An estimated 50 million Americans suffer from mild to ... especially for children and senior citizens. GenTel's protein chips ...
Cached Biology Technology:Supreme Court decision in eBay case could affect value of patents 2Big Pharma's continued hunger and search for new products 2Big Pharma's continued hunger and search for new products 3Big Pharma's continued hunger and search for new products 4GenTel gets federal grant to develop allergy test 2GenTel gets federal grant to develop allergy test 3
RAT ANTI MOUSE F4/80 ANTIGEN:BIOTIN Immunogen: Thioglycollate stimulated peritoneal macrophages from C57/BL mice...
SHEEP ANTI FLECAINIDE...
ANTI PIG LDH H4...
RAT ANTI MOUSE F4/80 ANTIGEN:BIOTIN Immunogen: Thioglycollate stimulated peritoneal macrophages from C57/BL mice...
Biology Products: