Navigation Links
Hopkins researchers discover how brain protein might control memory

Researchers at Johns Hopkins have figured out how one particular protein contributes to long-term memory and helps the brain remember things longer than an hour or two. The findings are reported in two papers in the Nov. 9 issue of Neuron.

The protein, called Arc, has been implicated in memory-linked behaviors ranging from song learning in birds to rodents being aware of 3-D space. In people, Arc may be one culprit behind certain long-term memory-based behaviors like drug addiction, the researchers say.

"We think Arc controls how brain cells learn and associate behaviors and remember them over a long period of time," says Paul F. Worley, M.D., professor of neuroscience and neurology at Hopkins and director of both studies. "For example, the person who quits smoking can wean himself from cravings at home, at work or outside. But if you put him in a bar with a drink in his hand, his brain remembers that former association and suddenly the craving returns. These types of long-term associations are memories wired in your brain."

Years ago, Worley and his colleagues, studying laboratory rats, found that their brains made lots of Arc protein while the animals were awake and active. In fact, it has been long known that stimulating individual nerve cells - by an act as simple as exploring new environs, for example - causes the cells to make more Arc protein almost immediately. "Arc is an instant and reliable readout for active cells in the brain," says Worley. But although scientists knew that active cells were making copious amounts of Arc, no one knew exactly what Arc was doing in those cells until now.

To figure out what Arc was doing, the Hopkins team looked for what other proteins Arc "plays" with. Using Arc protein as bait, they went on a molecular fishing expedition in a pond filled with other proteins normally found in the brain and hooked two known to be involved in transporting materials into and out of cells.

"Mov
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2 3

Related biology news :

1. Hopkins AIDS experts issue warning about global efforts to provide drug therapies
2. Hopkins scientists uncover tags that force proteins to cell surface
3. Johns Hopkins flu expert calls for mandatory vaccination of health care workers
4. Whole-genome study at Johns Hopkins reveals a new gene associated with abnormal heart rhythm
5. Hopkins researchers discover genetic switch that turns off an oxygen-poor cells combustion engine
6. Hopkins study suggests commercially available antibiotic may help fight dementia in HIV patients
7. Johns Hopkins lab scientists tame overactive CF protein
8. Hopkins researchers develop new tool to watch real-time chemical activity in cells
9. Hopkins scientists show hallucinogen in mushrooms creates universal mystical experience
10. Hopkins scientists link immune response to ghost parasites and severely congested sinuses
11. NYU researchers simulate molecular biological clock
Post Your Comments:
(Date:9/2/2014)... A study published in the September 2014 ... Academy of Child and Adolescent Psychiatry found ... diagnosis had an increased risk of developing diabetes ... data from the nationwide Danish registers, a group ... Psychiatry, Aalborg University Hospital, Denmark, studied 48,299children and ...
(Date:9/2/2014)... Bavaria, the Tithonian Konservat-Lagersttte of lithographic limestone is ... of emblematic fossils from that area (for example, ... found fossil insects in the French equivalent of ... species representing the oldest known water treader. , ... Bavarian outcrops, fewer fossils have been obtained from ...
(Date:9/1/2014)... has improved steadily in recent yearsspurred in large part ... poor and disparities continue to widen among socioeconomic and ... School of Public Health (HSPH). , "The study provides ... efforts by many groups and individuals to improve U.S. ... indicates that these efforts need to be expanded," said ...
Breaking Biology News(10 mins):Risk of diabetes in children and adolescents exposed to antipsychotics 2Exceptionally well preserved insect fossils from the Rhône Valley 2Quality of US diet shows modest improvement, but overall remains poor 2Quality of US diet shows modest improvement, but overall remains poor 3
... Spiders may not be the pure predators we generally believe, after ... diet by eating pollen. Dr Dirk Sanders of the University ... garden variety choose to eat pollen even when insects are ... trap aerial plankton like pollen and fungal spores. Dr Sanders, ...
... Dec. 17, 2013 Going back in time to compare ... , a University of Houston (UH) biologist hopes to one ... the likelihood it will become resistant to a particular antibiotic. ... is allowing associate professor Timothy Cooper and his team to ...
... one of the most diverse and abundant groups of ... important invasive insect pests around the globe. In the ... the avocado industry in Florida, and Asian ambrosia beetles ... are attacking trees in nurseries. However, despite their economic ...
Cached Biology News:Predicting antibiotic resistance among goals of UH research 2Meet the beetles -- the Xyleborini of New Guinea 2
(Date:9/2/2014)... , Sept. 2, 2014  Spherix Incorporated (SPEX) -- an ... monetization of intellectual property, today announced that the United ... to the Company in the month of August that ... The issued patents are: ... U.S.RE45,081 issued August 19, 2014; and , U.S.RE45,095 ...
(Date:9/1/2014)... The Collaborative R&D Terms and Agreements ... understanding and unprecedented access to the collaborative R&D ... leading life science companies. , The report provides ... why companies enter collaborative R&D deals. , Understanding ... terms provides critical insight into the negotiation process ...
(Date:8/30/2014)... TX (PRWEB) August 31, 2014 ... is a professional and in-depth study on the ... in Global and China. , The report provides ... applications and industry chain structure. Global market analysis ... a focus on history, developments, trends and competitive ...
(Date:8/29/2014)... August 29, 2014 Pittcon is pleased ... and colleague Koichiro Matsuda, Horiba Scientific, have organized a ... 5, 2014. JASIS , Asia’s largest analytical and ... in Makuhari Messe, Japan. , The four speakers ... Bioanalysis from Single Molecules to Single Cells” will present ...
Breaking Biology Technology:United States Patent & Trademark Office Issues Three New Standard Essential Patents to Spherix 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 3Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 4Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 2Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 3Fifth Annual U.S. Symposium at JASIS Organized by Pittcon’s Program Chairman Hub MacDonald 2
... PHILADELPHIA, Dec. 11 The following is,GlaxoSmithKline,s ... retrospective analysis by the,Institute for Clinical Evaluative ... Older Patients with,Diabetes"., GSK believes that ... Drug,Benefit (ODB) database has significant limitations and ...
... Replikins Ltd. today announced its,latest findings regarding ... The company,s software-driven analysis has found that the ... in addition, higher,counts now have been found in ... which has been linked to the lethality of,influenza ...
... ROCHESTER, N.Y., Dec. 11 Lucid, Inc., (http://www.lucid-tech.com ... has appointed Dr. Colin Stahel as Director, Asia ... was selected for the newly created,position based on ... twenty years of experience in the development of ...
Cached Biology Technology:GlaxoSmithKline Responds to JAMA Article on the ICES Thiazolidinediones and Cardiovascular Outcomes in Older Patients with Diabetes 2GlaxoSmithKline Responds to JAMA Article on the ICES Thiazolidinediones and Cardiovascular Outcomes in Older Patients with Diabetes 3GlaxoSmithKline Responds to JAMA Article on the ICES Thiazolidinediones and Cardiovascular Outcomes in Older Patients with Diabetes 4GlaxoSmithKline Responds to JAMA Article on the ICES Thiazolidinediones and Cardiovascular Outcomes in Older Patients with Diabetes 5Lethal Human H5N1 Influenza Virus Replikin Gene Still Upregulated 2Lucid Expands Support Internationally: Dr. Colin Stahel appointed Director for Asia Pacific Region 2
... by end-users to be "a delight to ... light microscopy and electronic imaging. With its ... not require much space and can easily ... The DM-BA300 combines Motic's own revolutionary Colour ...
When added to StemSep T Cell Enrichment cocktail, human TCRab TAC is designed to deplete human TCRab from samples to isolate gd T cells....
When added to either StemSep CD4+ or CD8+ T Cell Enrichment cocktails, human CD45RA TAC is designed to deplete human CD45RA from samples to isolate memory CD4+ or CD8+ T cells....
... 'SoftLinx software, a multitasking application capable ... the programming and operation of lab automation ... enough for custom modification by programmers. ... a simple drag-anddrop flowchart. If you can ...
Biology Products: