Navigation Links
Hope for a more effective and less toxic cancer drug

Detailed evaluation conducted at WEHI into a possible new cancer drug suggests that it may prove to be more effective and less toxic than current chemotherapeutic drugs.

Dr David Huang, Dr Andrew Roberts, Prof Jerry Adams and their teams from WEHI's cancer research divisions have been assessing the potential of a new compound, ABT-737, that was developed by US-based healthcare company, Abbott.

Under normal circumstances, human cells have a limited lifespan. They die when they are damaged, worn out or no longer needed by the body. When they die, these cells are replaced by new ones. The body depends on a normal and healthy process called programmed cell death - or apoptosis - to ensure that unwanted cells die on cue. If this process fails, then the damaged cells live on and multiply indefinitely and uncontrollably. This uncontrolled multiplication of rogue cells can lead to cancer.

Conventional chemotherapeutic drugs target and attempt to kill rapidly dividing cancer cells. This is sometimes successful in halting the disease, but these drugs inevitably damage many normal tissues. Hence, even when the chemotherapy works, the side effects for the patient can be very serious.

ABT-737 is a drug with a different strategy for attacking cancer. Rather than attempting to poison the rogue cells, the new drug attempts to reactivate the healthy and normal cell death program that failed to kill the unwanted cells on cue.

WEHI's leading researcher with the assessment project, Dr David Huang, explains, "Normally, the cell death machinery is switched on when damaged cells need to be removed. The failure of the machinery to be turned on when it should can lead to cancer. ABT-737 is a 'switch flicker' that kicks the cell death machinery into action. Much more remains to be done to assess the drug's safety and effectiveness in patients, but early results from the laboratory are promising. Our hope is that the new drug will prove to be more effective while having fewer side effects."

The findings of the scientific assessment team are published in the 13 November 2006 issue of the prestigious international journal Cancer Cell.


'"/>

Source:Research Australia


Related biology news :

1. Combination therapy boosts effectiveness of telomere-directed cancer cell death
2. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
3. Boosting HIV screening can increase survival and is cost effective
4. Live vaccines more effective against horse herpes virus
5. Man-made wetlands effectiveness similar to natural marsh
6. Wake Forest scientists find new combination vaccine effective against plague
7. UCLA study assesses cost-effectiveness of Hepatitis B drugs
8. New study: Sexually transmitted disease treatment can be effectively administered by sex partners
9. New vaccine protects more effectively against tuberculosis
10. Harmless virus may hold key to more effective HIV drug discovery
11. Structures of marine toxins provide insight into their effectiveness as cancer drugs
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... Today HYPR Corp. , leading innovator ... of the HYPR platform is officially FIDO® Certified ... architecture that empowers biometric authentication across Fortune 500 enterprises ... over 15 million users across the financial services industry, ... product suites and physical access represent a growing portion ...
(Date:4/3/2017)... , April 3, 2017  Data captured ... engineering platform, detected a statistically significant association ... prior to treatment and objective response of ... potential to predict whether cancer patients will ... treatment, as well as to improve both pre-infusion ...
(Date:3/30/2017)... NEW YORK , March 30, 2017 ... by type (physiological and behavioral), by technology (fingerprint, AFIS, ... recognition, voice recognition, and others), by end use industry ... travel and immigration, financial and banking, and others), and ... Europe , Asia Pacific ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... (PRWEB) , ... October 11, 2017 , ... ... Administration (FDA) has granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal ... the treatment of osteosarcoma. SBT-100 is able to cross the cell membrane and ...
(Date:10/10/2017)... Oct. 10, 2017 International research firm Parks Associates ... speak at the TMA 2017 Annual Meeting , October 11 in ... the residential home security market and how smart safety and security products ... Parks Associates: Smart ... "The residential security market ...
(Date:10/9/2017)... ... 2017 , ... The award-winning American Farmer television series will feature 3 Bar ... Tuesdays at 8:30aET on RFD-TV. , With global population estimates nearing ten billion ... continue to feed a growing nation. At the same time, many of our valuable ...
(Date:10/7/2017)... Seattle, WA (PRWEB) , ... ... ... the industry leader in Hi-C-based genomic technologies, launched its ProxiMeta™ Hi-C metagenome ... the ProxiMeta Hi-C kit and accompanying cloud-based bioinformatics software to perform Hi-C ...
Breaking Biology Technology: