Navigation Links
Hope for a more effective and less toxic cancer drug

Detailed evaluation conducted at WEHI into a possible new cancer drug suggests that it may prove to be more effective and less toxic than current chemotherapeutic drugs.

Dr David Huang, Dr Andrew Roberts, Prof Jerry Adams and their teams from WEHI's cancer research divisions have been assessing the potential of a new compound, ABT-737, that was developed by US-based healthcare company, Abbott.

Under normal circumstances, human cells have a limited lifespan. They die when they are damaged, worn out or no longer needed by the body. When they die, these cells are replaced by new ones. The body depends on a normal and healthy process called programmed cell death - or apoptosis - to ensure that unwanted cells die on cue. If this process fails, then the damaged cells live on and multiply indefinitely and uncontrollably. This uncontrolled multiplication of rogue cells can lead to cancer.

Conventional chemotherapeutic drugs target and attempt to kill rapidly dividing cancer cells. This is sometimes successful in halting the disease, but these drugs inevitably damage many normal tissues. Hence, even when the chemotherapy works, the side effects for the patient can be very serious.

ABT-737 is a drug with a different strategy for attacking cancer. Rather than attempting to poison the rogue cells, the new drug attempts to reactivate the healthy and normal cell death program that failed to kill the unwanted cells on cue.

WEHI's leading researcher with the assessment project, Dr David Huang, explains, "Normally, the cell death machinery is switched on when damaged cells need to be removed. The failure of the machinery to be turned on when it should can lead to cancer. ABT-737 is a 'switch flicker' that kicks the cell death machinery into action. Much more remains to be done to assess the drug's safety and effectiveness in patients, but early results from the laboratory are promising. Our hope is that the new drug will prove to be more effective while having fewer side effects."

The findings of the scientific assessment team are published in the 13 November 2006 issue of the prestigious international journal Cancer Cell.


'"/>

Source:Research Australia


Related biology news :

1. Combination therapy boosts effectiveness of telomere-directed cancer cell death
2. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
3. Boosting HIV screening can increase survival and is cost effective
4. Live vaccines more effective against horse herpes virus
5. Man-made wetlands effectiveness similar to natural marsh
6. Wake Forest scientists find new combination vaccine effective against plague
7. UCLA study assesses cost-effectiveness of Hepatitis B drugs
8. New study: Sexually transmitted disease treatment can be effectively administered by sex partners
9. New vaccine protects more effectively against tuberculosis
10. Harmless virus may hold key to more effective HIV drug discovery
11. Structures of marine toxins provide insight into their effectiveness as cancer drugs
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/6/2017)... , May 5, 2017 ... just announced a new breakthrough in biometric authentication ... exploits quantum mechanical properties to perform biometric authentication. These ... smart semiconductor material created by Ram Group and ... finance, entertainment, transportation, supply chains and security. Ram ...
(Date:4/17/2017)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... 2016 Annual Report on Form 10-K on Thursday April 13, 2017 ... ... Investor Relations section of the Company,s website at http://www.nxt-id.com  under ... http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... , Apr. 11, 2017 Research and ... Market 2017-2021" report to their offering. ... The global eye tracking market to grow at a ... report, Global Eye Tracking Market 2017-2021, has been prepared based on ... covers the market landscape and its growth prospects over the coming ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... Md. (PRWEB) , ... October 11, 2017 , ... ... digital pathology, announced today it will be hosting a Webinar titled, “Pathology is ... Advanced Pathology Associates , on digital pathology adoption best practices and how Proscia ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... has granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and ... of osteosarcoma. SBT-100 is able to cross the cell membrane and bind intracellular ...
(Date:10/10/2017)... , Oct. 10, 2017 International research firm Parks ... Strategy, will speak at the TMA 2017 Annual Meeting , October ... trends in the residential home security market and how smart safety and ... Parks ... "The residential ...
(Date:10/9/2017)... ... ... The award-winning American Farmer television series will feature 3 Bar Biologics in an ... on RFD-TV. , With global population estimates nearing ten billion people by 2050, ... a growing nation. At the same time, many of our valuable resources are becoming ...
Breaking Biology Technology: