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Highly adaptable genome in gut bacterium key to intestinal health

riendly, or symbiotic, species may be an important mechanism to avoid causing a potentially damaging or disruptive host immune response.

"B. theta is an incredibly sophisticated and versatile diner," says Justin Sonnenburg, Ph.D., W.M. Keck Foundation postdoctoral research scholar in the Center for Genome Sciences. "Instead of dying off when its usual source of food is gone, B. theta has evolved an elaborate mechanism for sensing changes in its nutrient landscape and quickly changing its dietary preferences so that it can use whatever is most plentiful. In fact, it can call on a larger repertoire of genes related to carbohydrate digestion than any other microbe we know of."

Next, the researchers will use germ-free mice to investigate how B. theta interacts with other members of the gut ecosystem. By defining the factors that underlie the stability of the gut ecosystem, they may be able to develop ways to manipulate the gut's bacterial community to promote health or treat diseases. For example, the group is assessing how the bacterial capacity for processing dietary carbohydrates varies among individuals and what influence that may have on weight.


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Source:Washington University School of Medicine


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