Navigation Links
Highly adaptable genome in gut bacterium key to intestinal health

A bacterium that lives in the human gut adaptively shifts more than a quarter of its genes into high gear when its host's diet changes from sugar to complex carbohydrates.

This adaptive mechanism not only allows the bacterial species to survive rapidly changing nutrient conditions but also helps maintain the functions and stability of the gut's highly complex microbial society, according to researchers at Washington University School of Medicine in St. Louis.

Their findings are reported in the March 25, 2005 issue of the journal Science.

"Bacterial cells in the human gut number close to 100 trillion," says Jeffrey Gordon, M.D., director of the Center for Genome Sciences at Washington University and professor of molecular biology and pharmacology. "Together, these microbes can be viewed as a 'microbial organ' that lives within the intestine and harvests, stores and redistributes energy from the diet."

Because changes in the composition of this "microbial organ" may be deleterious to human health, it is important to understand how gut microbes adapt to the dynamic environment of the gut and ensure the functional stability of the intestinal bioreactor, the researchers say. In addition, variations in the composition of gut microbial communities among different people may be an important factor that influences predisposition to obesity and obesity-related disorders such as diabetes and heart disease

The bacterium of the study, called Bacteriodes thetaiotaomicron or B. theta, is among the most abundant species in the human gut microbial community. B. theta breaks down otherwise indigestible carbohydrates, such as dietary fiber, and supplies its host with nutrients while obtaining food for itself and other gut bacterial species. The complete genome sequence of B. theta was generated two years ago in the same laboratory.

The researchers inoculated germ-free mice, who have no intestinal bacteria, with B. theta. The mice were fed
'"/>

Source:Washington University School of Medicine


Page: 1 2 3

Related biology news :

1. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
2. FDA: Highly Unlikely Green Tea Lowers Cancer Risk
3. Highly concentrated botulinum preparation for cosmetic injections can result in severe illness
4. Man and mouse share genome structures
5. Whole genome fine map of rice completed
6. Study finds more than one-third of human genome regulated by RNA
7. A bacterial genome reveals new targets to combat infectious disease
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Fleshing out the genome
10. Agilent Technologies new genome analysis technology set to accelerate Australia fight against mesothelioma
11. wFleaBase: the Daphnia genome database
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Highly adaptable genome gut bacterium key intestinal health

(Date:8/27/2014)... -- Duke University researchers have identified a gene that ... OSCA1, encodes a protein in the cell membrane of ... the plant,s water conservation machinery accordingly. , "It,s ... professor of biology at Duke. , The findings, ... , could make it easier to feed the world,s ...
(Date:8/27/2014)... neural circuits in the brain of mice, scientists ... The research, led by Howard Hughes Medical Institute ... Technology (MIT), reveals that the connections between the ... about an experience and the part of the ... experience are malleable. , Altering those connections ...
(Date:8/27/2014)... is entering what is described by the Volunteer Wildfire ... The Eastern Cape provincial government warned residents in certain ... winds and veld fires. A high veld fire ... along the coast in the Great Kei and Mnquma ... and during thunderstorms. The thunderstorms bring lightning strikes ...
Breaking Biology News(10 mins):Water 'thermostat' could help engineer drought-resistant crops 2Researchers change the emotional association of memories 2Researchers change the emotional association of memories 3Researchers change the emotional association of memories 4
... the Smiley lab at the Trudeau Institute have now identified ... be used as a vaccine. This single "subunit" could potentially ... cell-stimulating plague vaccine. The new data is featured in the ... "To date, there has been little progress in the development ...
... the next big innovation in sustainable climate technology? ... for Business Law and Regulation at Case Western Reserve ... do just that. "Technology-induced prizes have a long ... on a Climate Prize Rewarding Energy Innovation to Achieve ...
... Highlights: Advanced technologies create ... Radio was integrated easily with Army,s cellular biometric network ... Harris Corporation,s (NYSE: HRS ... infrastructure for various mission scenarios at the Empire Challenge 2011 ...
Cached Biology News:Trudeau Institute announces new discovery in battle against plague and bacterial pneumonias 2CWRU law professor eyes prize-based incentives to generate climate innovation 2Harris Corporation's Highband Networking Radio Provides Mobile, Wideband Communications for Empire Challenge 2011 2Harris Corporation's Highband Networking Radio Provides Mobile, Wideband Communications for Empire Challenge 2011 3
(Date:8/28/2014)... 28, 2014  Armetheon, Inc. ( www.armetheon.com ), ... to late-stage cardiovascular drug candidates, today announced that ... round of financing. The Series A round was ... with participation from investors that included Atheneos Capital ... Larry Hsu , the founder of Impax ...
(Date:8/28/2014)... PrimeSource Building Products, Inc., a ... SoundConnect to support their communication needs with ... web conferencing platform GlobalMeet powered by SoundConnect. The ... SoundConnect delivers award winning “results driven” business ... will be utilizing GlobalMeet powered by SoundConnect ...
(Date:8/27/2014)... 2014 Rhythm, a biopharmaceutical company developing peptide ... result in metabolic disorders, announced today that it has ... U.S. Securities and Exchange Commission (SEC) relating to the ... stock. The number of shares to be offered and ... been determined. Citigroup and Cowen and Company ...
(Date:8/27/2014)... The Global and China Trifluoroacetic Acid Industry ... state of the Trifluoroacetic Acid industry in Global and ... the industry, including definitions, applications and industry chain structure. ... provided with a focus on history, developments, trends and ... international and Chinese situation is also offered. , The ...
Breaking Biology Technology:Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 3PrimeSource Chooses SoundConnect as Collaboration Provider 2Rhythm Files Registration Statement for Proposed Initial Public Offering 2Trifluoroacetic Acid Industry (Asia, Europe, North America, ROW) Analysis Report Now Available at ReportsnReports.com 2
... educated nearly 80,000 patients in over 30 states on ... disease and treatment options since 1997, DEERFIELD, Ill., ... Baxter Healthcare Corporation,s Kidney Patient,Educator (KPE) program, an ambitious ... disease (CKD) and treatment options to,nearly 80,000 kidney disease ...
... at 11:45 am ET on November 8, 2007, ... (Nasdaq: TARG ) today announced its participation,in ... Conference, taking place November 8, 2007 at the,Hilton ... Officer of Targanta, will be presenting at 11:45 ...
... MNKD ) today announced results from a ... GLP-1 (glucagon-like peptide) on Technosphere,particles that is delivered ... as an open-label, dose escalation, controlled safety and,tolerability ... was assigned to one of five dose levels ...
Cached Biology Technology:Baxter Kidney Patient Education Program Celebrates Tenth Anniversary 2Baxter Kidney Patient Education Program Celebrates Tenth Anniversary 3Baxter Kidney Patient Education Program Celebrates Tenth Anniversary 4Targanta to Present at 9th Annual Mass Opportunities Investment Conference 2MannKind Announces Positive Results from a Phase 1a Study of a GLP-1 Formulation 2MannKind Announces Positive Results from a Phase 1a Study of a GLP-1 Formulation 3MannKind Announces Positive Results from a Phase 1a Study of a GLP-1 Formulation 4
... ViaSure Kit is used in conjunction with the ... cells automatically. The ViaSure Staining Reagent uses ... Acridine Orange and Ethidium Bromide to identify live ... while the EasyCount Slide 6 Multi-well Slide ...
... The Mini Trans-Blot cell and PowerPac Basic power ... to membranes. The Mini Trans-Blot cell accommodates two ... gel holder cassettes, modular electrode assembly, Bio-Ice cooling ... 4 fiber pads. The PowerPac basic power supply, ...
...
... SPE is a powerful, high-throughput workstation dedicated specifically for automating Solid Phase Extraction ... large volumes aqueous solution extractions (up to 2000ml's). ... ... ...
Biology Products: