Navigation Links
High-resolution light microscope reveals the fundamental mechanisms of nerve communication

n required to separate nanoscale structures was lacking due to the diffraction barrier.

In recent years researchers in the department of NanoBiophotonics at the MPI for Biophysical Chemistryin Göttingen have been able to break the Abbe resolution limit of far-field optical microscopy, as applied to fluorescent imaging, using a technique known as Stimulated Emission Depletion (STED) microscopy.The STED microscope used to obtain data for both publications is able to attain a resolution of 50-70 nm; the original fluorescent spot, roughly 200 nm in diameter, is reduced in surface area within the imaging plane by roughly an order of magnitude using the STED technique.

This resolution was sufficient for researchers from the neurobiology department to visualize, for the firsttime, individual synaptic vesicles - more precisely, to visualize the protein synaptotagmin, which is embedded in the membranes of individual vesicles. Vesicles are membrane 'bubbles' roughly 40 nm indiameter filled with neurotransmitters, which transport chemical messenger molecules to synapses, the contact points between nerve cells, enabling nerve signals to pass between cells. Their contents are released at the synapse when the vesicle membranes fuse with the membrane of the nerve cell. Previously it was unclear whether the proteins sticking in the vesicle membrane (e.g. synaptotagmin) spread out over the cell membrane after the fusion event or they remained together, localized in the membrane patch whichpreviously formed the vesicle. With the aid of STED microscopy the researchers in Göttingen were able to show that the synaptotagmin molecules of a single vesicle remain together after fusion. The membrane ofthe nerve cell thus behaves in an 'economical' fashion: the vesicle proteins released onto the membrane ofthe nerve cell can be collectively reabsorbed to form another vesicle.

Neural vesicles do not fuse with the cell membrane with equal probability at all locations alo
'"/>

Source:Max-Planck-Gesellschaft


Page: 1 2 3

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine
3. Bacteria collection sheds light on urinary tract infections
4. Sea skate experiment sheds light on human cell transport
5. X-Ray Beams And Fruit Fly Flight Simulator Aid Scientists View Of Muscle Power
6. McGill researchers shed light on formation of carcinogen in food
7. Scientists discover how plants disarm the toxic effects of excessive sunlight
8. Medical molecules designed to respond to visible light that can penetrate tissue
9. Genetic defects give the immune system the green light to attack the pancreas
10. Researchers find gene that may be at root of potato blight
11. Remote control flies? Fly behavior controlled by laser light
Post Your Comments:
(Date:7/11/2014)... BostonThe American Society for Bone and Mineral Research awarded ... of Medicine (BUSM), with the 2014 Louis V. Avioli ... at BUSM, is internationally known for revolutionizing the understanding ... , The award honors a member of the ... fundamental contributions to bone and mineral basic research. It ...
(Date:7/11/2014)... of researchers from The Chinese University of Hong Kong, ... wild soybean linked to salt tolerance, with implication for ... This study published online in Nature Communications ... for crop improvement. , Soybean is an important crop ... cultivated soybeans have less genetic diversities than their wild ...
(Date:7/11/2014)... 11, 2014 Researchers have pioneered a revolutionary ... new technology, called Virtual Finger, allows scientists to ... neurons and synapses using the flat surface of ... 3D imaging studies orders of magnitude more efficient, ... level across many areas of experimental biology. The ...
Breaking Biology News(10 mins):BUSM's Michael F. Holick receives American Society for Bone and Mineral Research award 2BGI reports a novel gene for salt tolerance found in wild soybean 2Virtual finger enables scientists to navigate and analyze complex 3D images 2
... Research published today reveals the previously unidentified role that fish ... and specifically of the carbonate sediments that contain critical records ... geological past. The discovery, made by a team of ... of a key component of marine sediments the fine-grained ...
... join the American Society for Nutrition (ASN) this weekend, ... Controversies in Clinical Nutrition Conference. As the leading authority ... sides of controversial nutrition topics in dietary supplements, obesity, ... science writers and bloggers, are invited to attend for ...
... who want to eat healthy and live sustainably ... on the environment: a Web-based tool [ http://n-print.org/sites/n-print.org/files/footprint_sql/index.html#/home ... device was created by University of Virginia environmental ... research assistant at U.Va.; and colleagues from the ...
Cached Biology News:Fish provide missing piece in the marine sediment jigsaw 2Fish provide missing piece in the marine sediment jigsaw 3New free, hands-on tool supports sustainable living choices 2New free, hands-on tool supports sustainable living choices 3
(Date:7/10/2014)... UK (PRWEB) July 10, 2014 ... 21st Century Medicine Forum on ‘Commercialising Longevity Research’ ... and entrepreneurs to the London Bioscience Innovation Center ... Research Foundation and Aging Analytics Ltd. The meeting ... investment in translational research for age-related disease, as ...
(Date:7/10/2014)... 10, 2014 Unraveling life’s mysteries can ... The Archer Family purchased a DNA test ... ended up with a lifetime of memories, sharing, and ... family members’ DNA genuinely brought the family closer together. ... deeper into genetic history and prior to taking the ...
(Date:7/10/2014)... 10, 2014 EvoDerma ’s NOOME Anti-Aging ... rejuvenating device now comes with a second treatment cup to ... , The new cup is thinner on the edges for ... target rough, thin and uneven surfaces on the face, neck ... a stimulating treatment on areas such as the cheeks and ...
(Date:7/10/2014)... July 10, 2014 On July ... Medvedev , presented Russia,s first ... . The Company is developing a unique project called ... BIOCAD develops a number of innovative drugs based on ... The ceremony took place at the International Exhibition "Innoprom ...
Breaking Biology Technology:DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2
... the weeks since DEMO 2007, I've had the chance to ... site, Jaman.com . Launched at the conference, Jaman.com offers ... or buy at prices that average about $6 per film. ... core of the Jaman.com experience is the downloadable player, a ...
... Wis. - Looking to raise more venture capital for ... 30 firms presenting at the annual InvestMidwest venture capital ... which also presented at the 2006 forum, would like to ... Phase I clinical trials that are set to begin in ...
... a recent column for the Wisconsin Technology Network , Gov. ... Wisconsin System fueling our state's economy. The governor missed the mark. ... the best in the country. In order to remain on top, however, ... done little of since it was created in 1971. The UW System ...
Cached Biology Technology:We're "Jaman": Purpose-driven browsers drive next wave of Web applications 2We're "Jaman": Purpose-driven browsers drive next wave of Web applications 3ZyStor seeks to raise $15M for clinical trials 2ZyStor seeks to raise $15M for clinical trials 3UW System must remove barriers to innovation 2UW System must remove barriers to innovation 3UW System must remove barriers to innovation 4
The PxE Thermal Cycler (PxE) is a licensed 96 well PCR machine, developed to provide all fundamental features for value for money thermal cycling....
Control primers and template for 5kb and 15 kb products....
Our original highly-purified, robust Taq Polymerase which delivers consistently high yields and minimal background...
...
Biology Products: