Navigation Links
High-powered gene profiles provide clues to genes involved in common form of lung cancer

Using technology that makes it possible to zoom in on smaller sections of cell chromosomes than ever before, researchers at Dana-Farber Cancer Institute have identified nearly 100 chromosome regions where genes are either over-copied or missing in non-small cell lung cancer. The findings provide new clues about the location of genes potentially involved in the most common type of lung cancer –?and one of the deadliest of all malignancies –?and a range of possible targets for future therapies.

The study will be reported in the Proceedings of the National Academy of Sciences' Online Early Edition (www.pnas.org/papbyrecent.shtml) the week of June 27.

"Previous studies have identified a small set of mutated, or abnormal, genes that are associated with non-small cell lung cancer," says the study's lead author, Giovanni Tonon, MD, PhD, of Dana-Farber. "But we also know that the chromosomes of these cells contain a large number of irregular regions –?where genes have either been deleted or copied over and over again –?which suggests that a large number of cancer genes remain to be discovered. The purpose of this study was to locate the likeliest candidates."

The study is part of a renewed effort by scientists worldwide to uncover the basic biology of lung cancer, the number one cause of cancer-related deaths in the United States. Non-small cell lung cancer (NSCLC) accounts for about 75 percent of all lung cancers and is responsible for nearly 120,000 deaths in this country annually. It is one of the most difficult cancers to treat, with only 15 percent of patients surviving more than five years after diagnosis.

In recent years, technological advances have brought new precision to the search for gene abnormalities associated with cancer. In the current study, Dana-Farber researchers used two forms of microarray technology to bring such abnormalities into focus.

Using tumor samples from 44 NSCLC patients and 34 laboratory-grown lines of
'"/>

Source:Dana-Farber Cancer Institute


Page: 1 2 3

Related biology news :

1. Towards precise classification of cancers based on robust gene functional expression profiles
2. Experiments provide proof of how traveling in groups protects insects
3. Experiments provide proof of how traveling in groups protects insects
4. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
5. MetaChip provides quick, efficient toxicity screening of potential drugs
6. Alaskan puzzles, monitoring provide insight about North Pacific salmon runs
7. NYU and MSKCC research provides model for understanding chemically induced cancer initiation
8. Nature provides inspiration for important new adhesive
9. Hydrogen and methane provide raw energy for life at Lost City
10. Research may provide new link between soft drinks and weight gain
11. Hopkins AIDS experts issue warning about global efforts to provide drug therapies
Post Your Comments:
(Date:9/17/2014)... retinoblastoma protein gene are a leading cause of eye ... fruit fly eyes to unlock the secrets of this ... on the cover of the current issue of the ... researchers provide the first detailed examination of a set ... cancer gene, said Irina Pushel, MSU undergraduate and co-author. ...
(Date:9/17/2014)... PROVIDENCE, R.I. [Brown University] After decades of decline, ... Cod,s saltmarshes. To the eye, the marsh in those ... clear that a key service of the marsh ... aesthetics back but the ecosystem function hasn,t come back," ... and senior author of the study in the journal ...
(Date:9/17/2014)... has learned a great deal about complex social behavior ... have something to teach too. , With their unusually ... cognition, parrots live in a complex social environment---not merely ... bees or ants, but in a dynamic setting of ... most intelligent mammals: dolphins, whales, primates, and social carnivores, ...
Breaking Biology News(10 mins):Abnormal properties of cancer protein revealed in fly eyes 2Cape Cod saltmarsh recovery looks good, falls short 2Cape Cod saltmarsh recovery looks good, falls short 3Being social: Learning from the behavior of birds 2
... cell factor overexpressed both in brain tumor cells and ... inducing angiogenesis. The research study, published in the April ... cells and surrounding tissues and may have substantial significance ... the most lethal types of tumor, malignant gliomas. ...
... play an important role in regulating blood flow in ... assumptions underlying today's most sophisticated brain imaging techniques and ... understanding Alzheimer's disease. , In a paper to appear ... available on-line, scientists at the University of Rochester Medical ...
... the Virginia Bioinformatics Institute at Virginia Tech have ... range of microbial genome sequences. , The VBI ... recent article published in Nucleic Acids Research (Vol.34, ... the plant pathogens Phytophthora sojae and Phytophthora ramorum. ...
Cached Biology News:Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons 2Blood flow in brain takes a twist, affecting views of Alzheimer's 2Blood flow in brain takes a twist, affecting views of Alzheimer's 3Virginia Bioinformatics Institutes launches microbial database 2
(Date:9/17/2014)... 17, 2014 The Alliance ... a multi-stakeholder non-profit collaborative building a global system ... research, today announced Phase 3 of its Site ... , Amir H. Kalali, Vice-President, Global Head, Neuroscience ... President, Compliance and Quality Integration (CQI) Consulting will ...
(Date:9/16/2014)... can harvest energy from jaw movements has been created ... is hoped that the device can generate electricity from ... small-scale implantable or wearable electronic devices, such as hearing ... , The first results of the device,s performance have ... Smart Materials and Structures . , Jaw movements ...
(Date:9/16/2014)... to cars and flashlights, batteries play an important ... constantly are seeking ways to improve battery life ... a water-based solution, researchers at the University of ... nuclear battery that could be used for many ... automobiles and also in complicated applications such as ...
(Date:9/16/2014)... Sept. 16, 2014 Cardioxyl Pharmaceuticals, Inc. ... has been shown to be effective in animal models ... alternative to intravenous infusions that could pave the way ... were presented yesterday at the Heart Failure Society of ... Las Vegas . The ...
Breaking Biology Technology:Global Standards Initiative for Clinical Research Sites Advances 2Global Standards Initiative for Clinical Research Sites Advances 3Global Standards Initiative for Clinical Research Sites Advances 4'Smart material' chin strap harvests energy from chewing 2Cardioxyl Presents Oral Heart Failure Treatment Data For Its Experimental HNO Prodrug At HFSA 18th Annual Scientific Meeting 2
... Popular Emergency Department Information, System Also Includes Embedded Web ... ... DALLAS, Oct. 24 T-System, Inc., the leading provider of,clinical ... announced the release of The T SystemEV(R),2.6.3, the newest upgrade to ...
... JERUSALEM, October 24 IDenta Corp. (Other,OTC: IDTA.PK) ... penetration of the United States and Oversees markets., ... Corporation (Encino,CA) and IDenta Corporation continues, has resulted ... quarters of 2008. Accutest(R) IDenta sales,have increased significantly ...
... held October 29-31 at the Palace Hotel, San,Francisco, ... Group, the world,s,marketplace for expertise, and the Biotechnology ... the Seventh Annual BIO Investor,Forum. Featured therapeutic panels ... consultants along with executives from public and,private equity ...
Cached Biology Technology:T-System Releases The T SystemEV(R) 2.6.3, Featuring New Meds/Allergies Notification, Automated Charge Capture 2T-System Releases The T SystemEV(R) 2.6.3, Featuring New Meds/Allergies Notification, Automated Charge Capture 3International Drug & Explosive Detection Firm Identa Corp Releasing: Jant Pharmacal Corporation Reports Successful Market Penetration of the Accutest(R) IDenta Co-brand in the United States and Oversees 2International Drug & Explosive Detection Firm Identa Corp Releasing: Jant Pharmacal Corporation Reports Successful Market Penetration of the Accutest(R) IDenta Co-brand in the United States and Oversees 3International Drug & Explosive Detection Firm Identa Corp Releasing: Jant Pharmacal Corporation Reports Successful Market Penetration of the Accutest(R) IDenta Co-brand in the United States and Oversees 4Gerson Lehrman Group and BIO Collaborate to Identify Scientific Expertise for the Seventh Annual BIO Investor Forum 2Gerson Lehrman Group and BIO Collaborate to Identify Scientific Expertise for the Seventh Annual BIO Investor Forum 3