Navigation Links
High-dose flu vaccines appear to safely boost immunity in elderly

High-dose influenza vaccines may increase elderly patients' immune response without significant adverse effects, offering this vulnerable population additional protection against the flu, according to an article in the May 22 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

Vaccines containing inactivated influenza virus have been available for 50 years to prevent flu and its complications, according to background information in the article. Immune responses decrease with age, however, and currently available flu vaccines are not always effective in the elderly. Recommended vaccines contain 15 micrograms (ìg) of inactivated virus per strain.

Wendy A. Keitel, M.D., Baylor College of Medicine, Houston, and colleagues studied the response to vaccines containing 15, 30 and 60 ìg of virus among 202 individuals age 65 years and older (average age 72.4) in 2002. The 60-ìg level was selected as the highest dosage because manufacturers would reasonably be able to produce that type of vaccine. Participants were randomly assigned to receive one of the three vaccines or a placebo injection and then were monitored daily for one week afterward. They were also examined 30 minutes, two days and 28 days after the vaccine and were contacted six months later to inquire about serious adverse events or side effects. Blood was drawn before the immunization and one month after.

On average, individuals who received higher dosages of vaccine had higher concentrations of antibodies against the flu virus in their blood one month later. In addition, a larger percentage of those who received the higher-dose vaccines had what physicians believe is a sufficient immune response to protect them from developing the flu if they were exposed to the virus. All three vaccine dosage levels were safe and well tolerated, according to the researchers. Although discomfort, redness or swelling at the site of the injection was more common among those who received the 60 ìg dose than among those who received the 15 ìg dose, most reactions to the immunization were mild.

Although current vaccines are sufficient to protect younger adults from influenza, the elderly and others at high risk of hospitalization and death from the disease have not responded consistently, the authors write. "Improved vaccines are needed to reduce the morbidity and mortality associated with influenza in these vulnerable populations," they write. "Increasing the dose of inactivated influenza vaccine consistently and safely increases the immunogenicity [immune response] of inactivated influenza virus vaccines; moreover, vaccines that contain higher doses have conferred significantly enhanced protection against naturally occurring influenza."


'"/>

Source:JAMA and Archives Journals


Related biology news :

1. High-dose anticlotting drug cuts heart attack, death risk in half
2. Live vaccines more effective against horse herpes virus
3. Designing vaccines by computer
4. Improving the potential of cancer vaccines
5. Report focuses on challenges to unlocking future promise of vaccines
6. Medical experts: US unlikely to have enough vaccines to stop avian flu
7. Plant-derived vaccines safeguard against deadly plague
8. Handling HPV vaccines and screening: The views of 100 authors
9. Protecting virus offers instant flu protection and converts flu infections into their own vaccines
10. Super enzyme may lead way to better tumor vaccines
11. Cellulose nanocrystal research could lead to new vaccines, computer inks
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/18/2017)... 18, 2017  Socionext Inc., a global expert in SoC-based imaging ... server, the M820, which features the company,s hybrid codec technology. A ... Tera Probe, Inc., will be showcased during the upcoming Medtec Japan ... at the Las Vegas Convention Center April ... Click here for ...
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market ... Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast ... from USD 14.30 Billion in 2017 to USD 31.75 Billion by 2022, ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... April 11, 2017 No two people ... at the New York University Tandon School of ... have found that partial similarities between prints are ... in mobile phones and other electronic devices can ... The vulnerability lies in the fact that fingerprint-based ...
Breaking Biology News(10 mins):
(Date:8/10/2017)... ... August 09, 2017 , ... As ... industry reach its ideal customers with the right message. Their effective, cutting-edge inbound ... Midwest company, we realize how crucial the agriculture industry is,” said David Phelps, ...
(Date:8/10/2017)... ... August 09, 2017 , ... The era ... clinic is here. The team at Capricor Therapeutics, Inc. utilized a cardiosphere-derived stem-like ... studies. , Dr. Travis Antes, head of analytical development at Capricor Therapeutics ...
(Date:8/10/2017)... ... August 09, 2017 , ... Okyanos Center for Regenerative ... at the Pelican Bay Hotel in Freeport, Grand Bahama on September 27, 2017. This ... , With oversight from the Ministry of Health’s National Stem Cell Ethics Committee ...
(Date:8/10/2017)... London UK (PRWEB) , ... August 10, 2017 , ... ... host a new educational webinar to demonstrate how Good Clinical Practice (GCP) ... and site documents. In addition the webinar will discuss the importance of GCP compliance, ...
Breaking Biology Technology: