Navigation Links
High-dose flu vaccines appear to safely boost immunity in elderly

High-dose influenza vaccines may increase elderly patients' immune response without significant adverse effects, offering this vulnerable population additional protection against the flu, according to an article in the May 22 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

Vaccines containing inactivated influenza virus have been available for 50 years to prevent flu and its complications, according to background information in the article. Immune responses decrease with age, however, and currently available flu vaccines are not always effective in the elderly. Recommended vaccines contain 15 micrograms (ìg) of inactivated virus per strain.

Wendy A. Keitel, M.D., Baylor College of Medicine, Houston, and colleagues studied the response to vaccines containing 15, 30 and 60 ìg of virus among 202 individuals age 65 years and older (average age 72.4) in 2002. The 60-ìg level was selected as the highest dosage because manufacturers would reasonably be able to produce that type of vaccine. Participants were randomly assigned to receive one of the three vaccines or a placebo injection and then were monitored daily for one week afterward. They were also examined 30 minutes, two days and 28 days after the vaccine and were contacted six months later to inquire about serious adverse events or side effects. Blood was drawn before the immunization and one month after.

On average, individuals who received higher dosages of vaccine had higher concentrations of antibodies against the flu virus in their blood one month later. In addition, a larger percentage of those who received the higher-dose vaccines had what physicians believe is a sufficient immune response to protect them from developing the flu if they were exposed to the virus. All three vaccine dosage levels were safe and well tolerated, according to the researchers. Although discomfort, redness or swelling at the site of the injection was more common among those who received the 60 ìg dose than among those who received the 15 ìg dose, most reactions to the immunization were mild.

Although current vaccines are sufficient to protect younger adults from influenza, the elderly and others at high risk of hospitalization and death from the disease have not responded consistently, the authors write. "Improved vaccines are needed to reduce the morbidity and mortality associated with influenza in these vulnerable populations," they write. "Increasing the dose of inactivated influenza vaccine consistently and safely increases the immunogenicity [immune response] of inactivated influenza virus vaccines; moreover, vaccines that contain higher doses have conferred significantly enhanced protection against naturally occurring influenza."


'"/>

Source:JAMA and Archives Journals


Related biology news :

1. High-dose anticlotting drug cuts heart attack, death risk in half
2. Live vaccines more effective against horse herpes virus
3. Designing vaccines by computer
4. Improving the potential of cancer vaccines
5. Report focuses on challenges to unlocking future promise of vaccines
6. Medical experts: US unlikely to have enough vaccines to stop avian flu
7. Plant-derived vaccines safeguard against deadly plague
8. Handling HPV vaccines and screening: The views of 100 authors
9. Protecting virus offers instant flu protection and converts flu infections into their own vaccines
10. Super enzyme may lead way to better tumor vaccines
11. Cellulose nanocrystal research could lead to new vaccines, computer inks
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/4/2017)... , Jan. 4, 2017  CES 2017 – ... biometric sensor technology, today announced the launch of ... sensor systems, the highly-accurate biometric sensor modules that ... biometric technology, experience and expertise. The two new ... designed specifically for hearables, and Benchmark BW2.0, a ...
(Date:12/20/2016)... Dec. 20, 2016 The rising popularity ... and leasing is stoking significant interest in keyless ... technology, Bluetooth low energy (BLE), biometrics and near-field ... next wave of wireless technologies in the automotive ... to advanced access systems opens the market to ...
(Date:12/16/2016)... 2016 Research and Markets has announced the ... Forecast to 2021" report to their offering. ... The biometric vehicle access system ... CAGR of 14.06% from 2016 to 2021. The market is estimated ... reach 854.8 Million by 2021. The growth of the biometric vehicle ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... CA (PRWEB) , ... January 19, 2017 , ... ... delivery of product vigilance software to leading biopharmaceutical and medical device manufacturers and ... is a fully 21 CFR Part 11-compliant email client designed to provide product ...
(Date:1/19/2017)... Mass. , Jan. 19, 2017 AquaBounty ... focused on enhancing productivity in aquaculture and a majority-owned ... announces that it has completed the listing of its ... the equity subscription from Intrexon. "AquaBounty,s listing ... that will broaden our exposure to the U.S. markets ...
(Date:1/19/2017)... , ... January 19, 2017 , ... FireflySci Inc. is ... rate. The tremendous growth is accounted to two main factors. The first ... the expanding network of vendors supplying FireflySci products all around the world. , 2016 ...
(Date:1/19/2017)... Jan. 18, 2017  Northwest Biotherapeutics, Inc. (OTCQB: NWBO) ... immune therapies for operable and inoperable solid tumor cancers, ... Technical Officer of NW Bio, will present at the ... at the Hyatt Regency Hotel in Miami, ... the session entitled "New Therapeutic Approaches – Expanding the ...
Breaking Biology Technology: