( Cigarette smoking and concurrent infect...)High HPV concentrations combined with smoking significantly raise risks of cervical cancer

Anthony Gunnell, a medical biostatistician and epidemiologist and colleagues at the Karolinska Institutet in Stockholm reviewed the medical exams of women with non-invasive cervical cancer in situ (the most common type) and cancer-free women in one of the largest studies to date to examine the relationships between smoking and the human papilloma virus (HPV). The virus and smoking behavior have long been associated with the disease, but not enough evidence has come forth to determine how either may cause the disease.

Gunnell's study, in fact, suggests that both may create a biochemical synergy that propels the disease. The researchers looked at "Pap" smear examination data from 105,760 Swedish women and identified 499 women with cervical cancer in situ, along with 499 cancer-free women as controls. For these women, they compared their smoking behavior with concentrations (known as viral load) of HPV-16, the viral strain most associated with cervical cancer. The researchers found that a combination of high viral loads and smoking during the time they were initially examined resulted in very high risk of later cervical cancer.

"We were surprised to see this dramatically increased risk among women with high viral loads who smoked," Gunnell said.

Among their findings:

• Women who smoked and had a high HPV-16 load during their first exam had a 27-fold increased risk of later cancer than women who smoked but did not have an HPV infection.

• Women who were positive for HPV-16 (irrespective of amount of viral load) and were smokers had a 14-fold increased risk over women who were HPV-16 negative and smoked.

• Nonsmoking women with high HPV
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