Navigation Links
Hexavalent chromium in drinking water causes cancer in lab animals

Researchers announced today that there is strong evidence a chemical referred to as hexavalent chromium, or chromium 6, causes cancer in laboratory animals when it is consumed in drinking water. The two-year study conducted by the National Toxicology Program (NTP) shows that animals given hexavalent chromium developed malignant tumors.

"Previous studies have shown that hexavalent chromium causes lung cancer in humans in certain occupational settings as a result of inhalation exposure," said Michelle Hooth, Ph.D., NTP study scientist for the technical report. "We now know that it can also cause cancer in animals when administered orally."

The study findings were announced at the National Institute of Environmental Health Sciences (NIEHS) after the NTP Board of Scientific Counselors Technical Reports Review Subcommittee completed its independent peer review of the sodium dichromate dihydrate research report. Sodium dichromate dihydrate is an inorganic compound containing hexavalent chromium that was used in the NTP studies. The NTP is located at the NIEHS, part of the National Institutes of Health.

Hexavalent chromium compounds are often used in electroplating, leather tanning, and textile manufacturing and have been found in some drinking water sources.

Male and female rats and mice were given four different doses of sodium dichromate dihydrate in their drinking water ranging from 14.3 mg/l to 516 mg/l for two years. The lowest doses given to the animals in the study were ten times higher than what humans could consume from the most highly contaminated water sources identified in California.

The researchers report finding significant increases in tumors at sites where tumors are rarely seen in laboratory animals. Male and female rats had malignant tumors in the oral cavity. The studies conducted in mice found increases in the number of benign and malignant tumors in the small intestine, which increased with dose i n both males and females.

"We found that hexavalent chromium is absorbed from the gastrointestinal tract," said Hooth. "After it is orally administered, it is taken up by the cells in many tissues and organs."

Hexavalent chromium has been brought to the public’s attention in many ways, most notably in the movie "Erin Brockovich." Eleven members from the California Congressional Delegation sent a letter to the NTP Director requesting the NTP conduct the studies. Nominations for studying this compound also came from the California Environmental Protection Agency and the California Department of Health Services. The NTP began work on this compound after gaining input from the public and a panel of scientific experts about the study design.
'"/>

Source:NIH/National Institute of Environmental Health Sciences


Related biology news :

1. Major new UNC-based drinking water study suggests pregnancy fears may be overstated
2. Ultrasounds show mothers drinking shrinks fetal brain
3. Brains can recover from alcoholic damage but patients should stop drinking as soon as possible
4. New UD technology removes viruses from drinking water
5. Anti-bacterial additive widespread in U.S. waterways
6. Unprecedented water level rise in Somalia
7. Microbial fuel cell: High yield hydrogen source and wastewater cleaner
8. Survey finds silver contamination in North Pacific waters
9. Researchers discover underwater volcano
10. Too much water may be as dangerous as too little during long-distance athletic events
11. Radio-tracking associated with dramatic shift in water vole sex ratio

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2016)... LONDON , April 26, 2016 ... a product subsidiary of Infosys (NYSE: ... to integrate the Onegini mobile security platform with ... http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The integration will ... to access and transact across channels. Using this ...
(Date:4/14/2016)... 2016 BioCatch ™, the ... announced the appointment of Eyal Goldwerger as ... Goldwerger,s leadership appointment comes at a time of ... deployment of its platform at several of the world,s ... discerns unique cognitive and physiological factors, is a winner ...
(Date:3/23/2016)... 2016 Einzigartige ... und Stimmerkennung mit Passwörtern     ... MESG ), ein führender Anbieter digitaler Kommunikationsdienste, ... SpeechPro zusammenarbeitet, um erstmals dessen Biometrietechnologie einzusetzen. ... Möglichkeit angeboten, im Rahmen mobiler Apps neben ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle Marche in ... peritoneal or pleural mesothelioma. Their findings are the subject of a new article on ... biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma patients that ...
(Date:6/23/2016)... TORONTO , June 23, 2016 /PRNewswire/ - ... Ontario biotechnology company, Propellon ... the development and commercialization of a portfolio of ... cancers. Epigenetic targets such as WDR5 represent an ... contribute significantly in precision medicine for cancer patients. ...
(Date:6/23/2016)... Cancer Foundation (PCF) is pleased to announce 24 new Young Investigator (YI) ... of the Class of 2016 were selected from a pool of 128 applicants ... the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... , ... June 23, 2016 , ... STACS DNA Inc., ... Leader at the Arkansas State Crime Laboratory, has joined STACS DNA as a Field ... DNA team,” said Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding ...
Breaking Biology Technology: