Navigation Links
Herpes virus hijacks DNA repair process

erbert W. "Skip" Virgin, M.D., Ph.D., Edward Mallinckrodt Professor and head of the Department of Pathology and Immunology, Tarakanova found that murine herpes virus, rather than the host cell, was triggering the DNA damage response. She showed that introducing just one viral protein into cells led to activation of two cellular proteins involved in the damage response, ATM and H2AX.

The viral protein that triggered this inappropriate activation, orf36, is a kinase, a type of protein that chemically modifies other molecules to activate different processes or transmit signals. Genetic comparisons with several human herpes viruses revealed kinases similar to orf36 in the human viruses. Scientists then took a similar kinase from human Epstein-Barr virus and showed that introducing it into cells also activated the DNA damage response.

When the research team genetically disabled orf36 in the murine herpes virus and infected mouse cells with it, the virus no longer activated the DNA damage response. The virus's ability to replicate also dramatically decreased.

Kinases are versatile proteins that sometimes play multiple roles. To ensure that enhanced viral replication wasn't linked to orf36's interactions with other molecules, researchers turned to mice lacking the genes for ATM and H2AX, the damage response proteins activated by infection. When they infected cells from these mice with murine herpes virus, its ability to reproduce was again curtailed. How DNA damage response benefits viral replication is still a mystery and a topic of continuing investigation in the Virgin lab.

"The discovery that induction of the cells' DNA damage response is an intentional viral strategy, rather than a passive cellular response to viral invasion, means that we should look into whether other DNA viruses use a similar approach to enhance their growth," says Virgin.


'"/>

Source:Washington University School of Medicine


Page: 1 2

Related biology news :

1. Herpes infection may be symbiotic, help beat back some bacteria
2. Association of herpesvirus with lung disorder questioned
3. Topical treatment shown to inhibit HIV and herpes simplex virus infection
4. Elusive HIV shape change revealed; Key clue to how virus infects cells
5. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
6. Live Recombinant Adenovirus Vaccine Technique Explored
7. Marburg virus disease in Angola - update
8. Studies reveal methods viruses use to sidestep immune system
9. Norovirus, AIDS vaccine and Hepatitis Virus
10. Epstein-Barr virus protein crucial to its role in blood cancers
11. Live vaccines more effective against horse herpes virus
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Herpes virus hijacks DNA repair process

(Date:3/16/2015)... Germany , March 16, 2015 ... Identification Systems GmbH will present groundbreaking innovations in ... Hanover, Germany .      ... DERMALOG,s latest biometric innovation is well at the ... next generation e-gate made in Germany ...
(Date:3/11/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/3p32qm/access_control ) has ... by Product, Application & By Geography - Global Forecast ... , This report predicts that the access ... 2020, with an estimated CAGR of 10.6%. ... such as contact cards & readers, contactless cards & ...
(Date:3/10/2015)... 2015  NXT-ID, Inc. (NASDAQ: NXTD ... biometric authentication company focused on the growing mobile ... has been named the "Number One Best Tech ... Rethink Modern ( http://www.rethinkmodern.com/ ) is a web ... and lifestyle that have a unique function or design.  ...
Breaking Biology News(10 mins):DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4
... report in the journal Development ( dev.biologists.org ... of a type of cell that can make myelin, ... basic and clinical research. The cells the researchers ... myelin in the central nervous system. Myelin forms an ...
... field stations have long been home to a rich ... places for serendipitous discoveries in the biological and environmental ... issue of the journal BioScience , researchers affiliated ... Research (LTER) Network and other groups state that few ...
... as contributing to autoimmune disease, but a review appearing ... of vitamin D in patients with autoimmune disease may ... and that supplementing with vitamin D may actually exacerbate ... at the California-based non-profit Autoimmunity Research Foundation, the paper ...
Cached Biology News:Human ES cells progress slowly in myelin's direction 2Field stations foster serendipitous discoveries in environmental, biological sciences 2Field stations foster serendipitous discoveries in environmental, biological sciences 3Vitamin D may exacerbate autoimmune disease 2
(Date:3/26/2015)... Ale Gicqueau, Founder and President of Clinovo, will ... Align Technology, on “ Conducting Postmarket Registries - Rationale ... Conference and Exhibition on April 25th through April 28th ... poster presentation, Ale Gicqueau and Victor Chen will discuss ... the requirements and resources to conduct the registry, as ...
(Date:3/25/2015)... Agnition announced today that it will be featured ... the first time at 7:30 a.m. CST March 31 ... the extremely important role soil microbes perform in crop ... Catalyst™ technology that enhances soil and plant health for ... again on April 28. , A biochemist at Agnition ...
(Date:3/25/2015)... UK (PRWEB) March 25, 2015 ... uptake of smartphones have fuelled social media growth, ... being currently engaged in social networking. Insurance companies ... to communicate with clients and promote a diversity ... globe over are increasingly exploiting social networking services ...
(Date:3/25/2015)... Md. , March 25, 2015 Accelovance, ... named a finalist for "Best Contract Research Organization" at ... the World Vaccine Congress. This is ... a finalist for the award, winning for "Best Contract ... a "Highly Recommended" distinction in 2013. "We,re ...
Breaking Biology Technology:Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 2Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 3Agnition to be Featured In Upcoming Episode of American Farmer on RFD-TV 2Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 2Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 3Accelovance Nominated for 2015 Vaccine Industry Excellence (ViE) Awards 2
... , , , , , ... company,providing customized enzymes to the pharmaceutical, chemical, and other,industries, announced today ... from existing shareholders. , The Company ... product portfolio and to accelerate the development of international,markets. At the ...
... , This release is available in German ... display case. A white light appears out of nowhere. And ... glance. Only upon close examination does the source of the ... a pinhead, passes through thousands of infinitesimal lens structures measuring ...
... EMERYVILLE, Calif. , Feb. 2 Onyx Pharmaceuticals, ... at the 12th Annual BIO CEO & Investor Conference on ... ( 5:30 a.m. Pacific Time ).  Interested parties may access ... , http://www.onyx-pharm.com/view.cfm/32/Event-Calendar , It is recommended that listeners log ...
Cached Biology Technology:EUCODIS Bioscience Receives EUR 2 Million Cash Injection to Enlarge Product Portfolio and Develop International Markets 2EUCODIS Bioscience Receives EUR 2 Million Cash Injection to Enlarge Product Portfolio and Develop International Markets 3Nano for the senses 2Nano for the senses 3Onyx Pharmaceuticals to Present at the 12th Annual BIO CEO & Investor Conference 2
Recombinant Ovine (Sheep) Prolactin, Ultra Pure...
... HT, 1 kit. Facilitates the simple, phenol-free ... and hard tissue requiring proteinase K digestion.Each ... DNA from 50 preparations of up to ... Synthesis & Purification, Purification and Amplification of ...
... For rapid and efficient purification of DNA ... 15 minutes by gravity flow.Prepacked with Sephadex ... 0.15% Kathon CG/ICP Biocide.Available in three sizes ... (NAP-5), 1 ml (NAP-10) or 2.5 ml ...
Human ROR1 Affinity Purified Polyclonal Ab...
Biology Products: