Navigation Links
Hepatitis C therapy: Inhibiting newly discovered microDNA molecule

Last fall Dr. Peter Sarnow and a team of Stanford University scientists reported that the hepatitis C virus needs a specific microRNA, named miR-122, in order to replicate in cultured liver cells.

When the scientists inactivated the microRNA, the amount of hepatitis C virus RNA was reduced by approximately 80 percent. The discovery was widely heralded for its potential to develop new antiviral agents against hepatitis C, the most common blood-borne viral infection in the United States, affecting more than 2.5 million Americans and a staggering 170 million people worldwide. The best treatment regimens now available are difficult, expensive, laden with serious side effects and effective in only half the cases.

Dr. Sarnow discusses the most recent findings in this work on April 5 at Experimental Biology 2006 in San Francisco. His presentation is part of the scientific program of the American Society for Biochemistry and Molecular Biology.

MicroRNAs, or miRNAs for short, are small RNA molecules that regulate genes in many plant and animal species. Although miRNAs were not discovered until the mid-1990, a growing number of studies suggest that over 300 human genes encode microRNAs and that these microRNAs may control gene expression for as much as a third of the human genome, acting as key regulators of processes as diverse as early development, cell proliferation and cell death, and cell differentiation. Some miRNAs are located throughout the body, while others are found only in specific tissue. The miRNA whose surprising new role was discovered by Dr. Sarnow and his colleagues is located only in the liver. The Sarnow team found that miR-122 binds to a specific noncoding binding region in virus, called target 5' NCR. This is the first example of an animal RNA that interacts with its target 5' NCR, and opens an interesting possibility that other viral 5' NCRs are similarly targeted by different miRNAs.


'"/>

Source:Federation of American Societies for Experimental Biology


Page: 1

Related biology news :

1. Scientists Replicate Hepatitis C Virus in Laboratory
2. Norovirus, AIDS vaccine and Hepatitis Virus
3. UCLA study assesses cost-effectiveness of Hepatitis B drugs
4. Natural Killers Could Lead to New Hepatitis Treatments
5. FDA Approves New Treatment for Chronic Hepatitis B
6. Identification of specific genes predicts which patients will respond to Hepatitis C treatment
7. Hepatitis C responds best to combo of ribavirin and interferon, study concludes
8. Use of high hydrostatic pressure to inactivate Hepatitis A virus in oysters studied
9. Hepatitis C complicated by morphine withdrawal
10. Hepatitis B accounts for 40 percent of missing Asian women
11. Hepatitis E takes a piggyback
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/23/2017)... robotic gym for the rehabilitation and functional motor sense evaluation of lower ... . The first 30 robots will be available from June in ... The technology was developed and patented at the IIT laboratories and has ... to a 10 million euro investment from entrepreneur Sergio Dompè. ... ...
(Date:5/6/2017)... 2017 RAM Group , Singaporean ... breakthrough in biometric authentication based on a ... to perform biometric authentication. These new sensors are based ... by Ram Group and its partners. This sensor will ... chains and security. Ram Group is a next ...
(Date:4/18/2017)... 18, 2017  Socionext Inc., a global expert in SoC-based imaging ... server, the M820, which features the company,s hybrid codec technology. A ... Tera Probe, Inc., will be showcased during the upcoming Medtec Japan ... at the Las Vegas Convention Center April ... Click here for ...
Breaking Biology News(10 mins):
(Date:6/16/2017)... ... 2017 , ... Cognition Corporation , a software company ... of its “From the Helm” Webinar Series. , The next two free ... design control exercises. Led by David Cronin, Cognition’s CEO, the half-hour public webinars ...
(Date:6/16/2017)... (PRWEB) , ... June 16, 2017 , ... CTNext ... Entrepreneur Innovation Awards (EIA), held at The LOFT at Chelsea Piers in Stamford. , ... ideas to a panel of judges for an opportunity to secure $10,000 awards to ...
(Date:6/15/2017)... ... June 15, 2017 , ... ... secured a Series B round of financing in the amount of $6 million. ... private investors participated in the round. , The Series B funding will enable ...
(Date:6/15/2017)... , ... June 15, 2017 , ... ... a promising new medical device startup. Dan Parsley, angelMD’s SVP of Corporate Development, ... members, and this angelMD syndicate is part of Saranas’ recently announced $4 million ...
Breaking Biology Technology: