Navigation Links
Hepatitis C complicated by morphine withdrawal

Researchers at the University of Pennsylvania have demonstrated that morphine withdrawal complicates hepatitis C by suppressing IFN-alpha-mediated immunity and enhancing virus replication. The paper by Wang et al., Morphine withdrawal enhances hepatitis C virus (HCV) replicon expression, appears in the November issue of The American Journal of Pathology and is accompanied by a commentary.

Hepatitis C virus (HCV) is common among intravenous drug users, with 70 to 80% of abusers infected in the United States. This high association has peaked interest in determining the effects of drug abuse, specifically opiates, on progression of the disease. The discovery of such an association would impact treatment of both HCV infection and drug abuse.

Dr. Wen-Zhe Ho has been interested in such interplay for some time. His laboratory has previously shown using cell culture that morphine enhances virus replication and inhibits IFN-alpha (a natural anti-viral factor produced by immune, as well as host cells, and the only one approved in recombinant form for treating HCV infection). To further these results, his lab has used a cell model system to determine the consequences of morphine withdrawal, which is a common recurring event in opioid users.

Chuan-Qing Wang and colleagues examined the effects of morphine withdrawal (MW) on HCV-infected cultured liver cells by exposing cells to the drug for four days followed by its removal. They also assessed the effects of using naloxone, to block the opioid receptors, in conjunction with drug removal, i.e. precipitated morphine withdrawal (PW). To measure HCV replication, they used a virus-like replicon that mimics the events that occur in liver cells and expression of viral RNA and proteins that HCV uses. Although the replicon does not produce the infectious virus, the HCV replicon system represents the best available system for examining the impact of opiates on HCV at the time of their research study. <
'"/>

Source:American Journal of Pathology


Page: 1 2

Related biology news :

1. Scientists Replicate Hepatitis C Virus in Laboratory
2. Norovirus, AIDS vaccine and Hepatitis Virus
3. UCLA study assesses cost-effectiveness of Hepatitis B drugs
4. Natural Killers Could Lead to New Hepatitis Treatments
5. FDA Approves New Treatment for Chronic Hepatitis B
6. Identification of specific genes predicts which patients will respond to Hepatitis C treatment
7. Hepatitis C responds best to combo of ribavirin and interferon, study concludes
8. Use of high hydrostatic pressure to inactivate Hepatitis A virus in oysters studied
9. Hepatitis B accounts for 40 percent of missing Asian women
10. Hepatitis C therapy: Inhibiting newly discovered microDNA molecule
11. Hepatitis E takes a piggyback
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Hepatitis complicated morphine withdrawal

(Date:7/11/2014)... Research and Markets has announced ... - Industry Analysis Size Share Growth Trends and Forecast ... http://photos.prnewswire.com/prnh/20130307/600769 The rising ... need for high level security in both private and ... as username and passwords, tokens etc. are vulnerable to ...
(Date:7/10/2014)... COLORADO SPRINGS, Colo. , June 27, 2014 ... announces that the National Institute of Standards and ... appointed 10 of its academic research and forensic ... Board (FSSB).  The Board is an element of ... These AAFS members are among the first appointments ...
(Date:7/10/2014)... BELL, Pa. , July 2, 2014  Unisys Corporation,s ... Netherlands , Unisys Nederland N.V., today announced that it ... to deliver, implement and manage a new Basic Provision Biometrics ... Unisys won the contract with a solution ... identity management software. The term of the contract is up ...
Breaking Biology News(10 mins):International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 2Unisys Delivers New Basic Provision Biometrics Solution to Dutch Custodial Institutions Service 3
... definitive studies of its kind to date, a team ... proven that organically grown kiwifruit contain more health-promoting factors ... reported in the SCI’s magazine Chemistry & Industry. The ... conventional food has raged for years, with UK environment ...
... even small quantities of ozone may actually make the ... household cleaning products, scientists at UC Irvine have discovered. ... air with unsaturated volatile organic compounds such as limonene ... a lemon fragrance ?to create additional microscopic particles, scientists ...
... the University of York have won a grant of £110,000 ... , Dr Jason Lynam and Dr Ian Fairlamb, of ... by the Leverhulme Trust for a three-year study into the ... monoxide into the bloodstream. , Carbon monoxide is an ...
Cached Biology News:Organic is healthier: Kiwis prove that green is good 2Organic is healthier: Kiwis prove that green is good 3Organic is healthier: Kiwis prove that green is good 4In presence of fragrant cleaning products, air purifiers that emit ozone can dirty the air 2Research to spotlight carbon monoxide benefits 2
(Date:7/10/2014)... 2014 On July 9 Prime ... presented Russia,s first national "Industry" ... Company is developing a unique project called MabNext ... a number of innovative drugs based on monoclonal antibodies ... took place at the International Exhibition "Innoprom 2014" in ...
(Date:7/10/2014)... Utah , July 10, 2014 /PRNewswire-iReach/ ... annotation and interpretation, today announced an agreement ... (NGS) analytics for Lineagen,s NextStep Dx ... of neurodevelopmental and neurological disorders, currently offers ... microarray (CMA) testing service used by healthcare ...
(Date:7/10/2014)... THOUSAND OAKS, Calif., July 10, 2014   Ceres, ... biotechnology and seed company, announced today financial results for ... an update on its business. Ceres reported ... progress in product performance this growing season in Brazil, ... that affected the company,s sorghum evaluation areas for part ...
(Date:7/10/2014)... fight against terrorism with the creation of a sensor ... use of light and special glass fibres. , Published ... , the researchers describe a novel optical fibre sensor ... 6.3 ppm (parts per million). It requires an analysis ... detection has involved looking for metals that encase them ...
Breaking Biology Technology:Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Detecting trace amounts of explosives with light 2
... Prevalence and Roles of miRNAs , ... and sequenced from human and mouse samples. ... genes, and miRNAs are thought to , ... predict mRNA target sites for miRNAs [2,3]. A handful of these , ...
... , ... RNAs , Prepare high specific activity RNA or DNA probes , ... , Contains reagents to prepare Decade Markers and single-base ... , The new <A , ...
... Reagents and , ... Superior identification of target cells provided by , ... Designed for use , with frozen, OCT-embedded tissue ... Compatible with Arcturus LCM Systems , Use with , ...
Cached Biology Technology:Reagents for Up and Down-Regulation of miRNA Activity in Mammalian Cells 2Reagents for Up and Down-Regulation of miRNA Activity in Mammalian Cells 3Reagents for Up and Down-Regulation of miRNA Activity in Mammalian Cells 4Reagents for Up and Down-Regulation of miRNA Activity in Mammalian Cells 5Reagents for Up and Down-Regulation of miRNA Activity in Mammalian Cells 6Reagents for Up and Down-Regulation of miRNA Activity in Mammalian Cells 7Reagents for Up and Down-Regulation of miRNA Activity in Mammalian Cells 8Reagents for Up and Down-Regulation of miRNA Activity in Mammalian Cells 9Rapidly Prepare Probes and Markers for Small RNA Analysis 2Rapidly Prepare Probes and Markers for Small RNA Analysis 3Rapidly Prepare Probes and Markers for Small RNA Analysis 4Protect RNA and Improve Target Cell Identification 2Protect RNA and Improve Target Cell Identification 3Protect RNA and Improve Target Cell Identification 4Protect RNA and Improve Target Cell Identification 5Protect RNA and Improve Target Cell Identification 6
50 assays. Provides an easy system for rapid separation of cytosol and particulate fractions that are compatiable with downstream studies....
Eliminate electrical interference from any analog signal, without filtering. Ideal for electrophysiology applications like EKG, EMG, and EEGs. Removes 50/60hz noise and harmonics caused by grounding ...
... SizeSep 400 Spun Columns, 10. *SizeSep ... cDNAs > 400 base pairs in length. ... Sepharose CL-4B and pre-equilibrated in distilled water containing ... smaller than ~ 400 base pairs. ...
... 25 purifications. Allows rapid purification ... removal of unincorporated CyDye label and ... yields of labeled cDNA probe. ... labeled by either direct incorporation or ...
Biology Products: