Navigation Links
Heart smart: new drug improves blood flow

A new drug has been shown to improve blood flow in diseased arteries, reducing the risk of high blood pressure and heart attacks, a Monash University study published today reveals.

The finding is a significant development for the Monash team that, in conjunction with Bayer Health Care, hopes to use the drug as part of a revolution in the management of heart disease.

Dr. Harald Schmidt, Director of the Centre for Vascular Health and his colleagues at Monash University, Dr. Peter Schmidt and Barbara Kemp-Harper, say the next step will be to translate the research so it benefits patients. Clinical trials of the drug have already started for the treatment of acute heart failure.

Dr. Schmidt's team and colleagues in Germany and the US have previously shown that oxidative stress - the appearance of free radicals in the walls of arteries - is a key mechanism underlying cardiovascular disease.

"Free radicals contribute to the formation of arterial blockages. What's more, as the number of free radicals increases, they also interfere with the ability of the cells lining arteries to control the contraction and dilation of the arteries," Dr. Schmidt says. "The arteries stiffen and get blocked."

When a blockage occurs, the cells lining the arteries produce nitric oxide to signal to the arterial muscles that they need to dilate the artery and allow more blood through. But free radicals destroy a key enzyme that allows the arterial cells to respond in this way, so the signal doesn't get through.

However, the new drug ?developed by Bayer HealthCare ?reactivates the damaged enzyme.

"Our results show that the drug directly binds to and repairs the damaged enzyme. And as the number of free radicals increases, the drug starts working harder," says Dr. Schmidt.

The results have been published in the Journal of Clinical Investigation and the September issue of Nature Reviews/Drug Discovery.

Dr. Schmidt, toget
'"/>

Source:Research Australia


Page: 1 2

Related biology news :

1. HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs
2. Implanted Devices Detect High-Risk Heart Failure Patients
3. Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments
4. Special Imaging Study Shows Failing Hearts Are Energy Starved
5. Stem Cell Research Shows Potential for Replacing Tissue Damaged in Heart Attacks
6. Heart repair gets new muscle
7. Male Combat Veterans Rank High In Heart Disease Risk
8. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
9. Researchers Find Drug May Give Some Cardiac Protection 24 Hours After Heart Attack
10. Heart-healthy compound in chocolate identified
11. Heart has enough oxygen to survive hypothermia, CPR crucial
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Heart smart new drug improves blood flow

(Date:7/10/2014)... , July 7, 2014 Fingerprint Cards, ... major design win (DW). A Chinese Top 5 smartphone OEM ... start of mass production in October 2014.   ... Top 5 smartphone OEM, which has a planned date for ... target sales volume for this phone of 3 million units. ...
(Date:7/10/2014)... GOTHENBURG, Sweden , July 8, 2014 ... FPC1021 has won a new design win (DW). An Asian ... targeted date for mass production start in August 2014.   ... an Asian smartphone OEM, which has a planned date for ... received an initial ramp order of SEK 5M, for delivery ...
(Date:7/10/2014)... Ill. , July 9, 2014 ... (EHR), spurred in large part by meaningful use ... health care providers interact with laboratory information. Now, ... in the field of clinical informatics in order ... To address the educational needs of ...
Breaking Biology News(10 mins):FPC Wins DW for 1021 Touch Sensor for Flagship Smartphone from Chinese Top 5 Smartphone OEM 2FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2New Clinical Informatics Curriculum Prepares Future Pathologists 2New Clinical Informatics Curriculum Prepares Future Pathologists 3New Clinical Informatics Curriculum Prepares Future Pathologists 4
... Marta Barrachina, Institute of Neuropathology of the Bellvitge Biomedical ... patients suffering from schizophrenia characterized by motor disorders. ... collaboration with the research team Mairena Martin at the ... clinical researchers of the Health Park Sant Joan de ...
... The Clinical Nutrition Research Centre (CNRC) -- a ... and Research (A*STAR) and National University Health Systems (NUHS) ... that will conduct nutritional studies to understand the causes ... develop products and formulate diets that can reduce the ...
... LAKE CITY, Utah, Jan. 29, 2014 Myriad Genetics, ... a clinical utility study with its Prolaris test, at ... Calif. The study demonstrated the significant clinical value ... prostate cancer. Prolaris is a prognostic test that ...
Cached Biology News:Identified a subgroup of schizophrenia patients with motor disorders 2Asia's first under-1-roof Nutritional Research Centre set up in Singapore 2Asia's first under-1-roof Nutritional Research Centre set up in Singapore 3Asia's first under-1-roof Nutritional Research Centre set up in Singapore 4Myriad's Prolaris significantly modifies treatment decisions for prostate cancer patients 2
(Date:7/11/2014)... -- Researchers have pioneered a revolutionary new way to ... Virtual Finger, allows scientists to move through digital ... using the flat surface of their computer screens. ... orders of magnitude more efficient, saving time, money ... areas of experimental biology. The software and its ...
(Date:7/10/2014)... UK (PRWEB) July 10, 2014 ... 21st Century Medicine Forum on ‘Commercialising Longevity Research’ ... and entrepreneurs to the London Bioscience Innovation Center ... Research Foundation and Aging Analytics Ltd. The meeting ... investment in translational research for age-related disease, as ...
(Date:7/10/2014)... Robert Harman, DVM, Founder and CEO of Vet-Stem, Inc., the ... relaunch of his highly informative blog, now named Stem Cells ... are Stem Cells ?” Dr. Harman’s purpose for blogging ... basics of stem cell therapy so that pet owners can ... when considering regenerative medicine. , A veterinarian by trade, Dr. ...
(Date:7/10/2014)... 10, 2014  Franciscan St. Anthony Health-Crown ... for respiratory monitoring outside the operating room, ... in embracing state-of-the-art patient safety technology. ... breathing and can alert medical caregivers when ... amount of carbon dioxide the patient is ...
Breaking Biology Technology:Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2
... SAN DIEGO, March 3, 2011 Anadys Pharmaceuticals, Inc. (Nasdaq: ... patient care by developing novel medicines for the treatment of ... for the fourth quarter and year ended December 31, 2010. ... well-positioned to create value in the evolving HCV landscape," said ...
... 2011 Novavax, Inc. (Nasdaq: NVAX ) ... visit the company,s headquarters in Rockville, Maryland, on Monday, ... at up to $179 million. The Office of Biomedical ... of the Assistant Secretary for Preparedness and Response at ...
... Executive search firm Sanford Rose Associates® - Minneapolis ... engagement for Nordson Corporation: Lise W. Duran as General ... of biomaterial applicators used in a wide variety of ... years of experience in the medical device industry, having ...
Cached Biology Technology:Anadys Pharmaceuticals Reports Fourth Quarter and Year-End 2010 Financial Results and Highlights 2Anadys Pharmaceuticals Reports Fourth Quarter and Year-End 2010 Financial Results and Highlights 3Anadys Pharmaceuticals Reports Fourth Quarter and Year-End 2010 Financial Results and Highlights 4Anadys Pharmaceuticals Reports Fourth Quarter and Year-End 2010 Financial Results and Highlights 5Anadys Pharmaceuticals Reports Fourth Quarter and Year-End 2010 Financial Results and Highlights 6Anadys Pharmaceuticals Reports Fourth Quarter and Year-End 2010 Financial Results and Highlights 7Maryland Governor Martin O'Malley to Visit Novavax in Celebration of HHS-BARDA Contract Award 2Maryland Governor Martin O'Malley to Visit Novavax in Celebration of HHS-BARDA Contract Award 3Maryland Governor Martin O'Malley to Visit Novavax in Celebration of HHS-BARDA Contract Award 4Sanford Rose Associates® - Minneapolis Fills Key Management Position for the Micromedics Operation of Nordson Corporation 2