Navigation Links
Heart repair gets new muscle

Some organs in the human body deal with injury better than others. A flesh wound or muscle tear might hurt, but, assuming you are otherwise healthy, both will heal. The prognosis for a heart attack, on the other hand, is not so clear-cut.

It has long been thought that cardiac cells (cardiomyocytes) lack the capacity for self-renewal and repair, impeding the chances of a full recovery from a heart attack. However, recent evidence suggests that the heart might harbor stem cells after all and that such cells can be transformed into cardiomyocytes.

In a new study published in the premier open-access online journal PLoS Biology, Neal Epstein and colleagues report that a special group of cells (called skeletal precursors of cardiomyocytes, or Spoc cells) isolated from the skeletal muscle of adult mice can turn into beating cardiomyocytes in a test tube within days of isolation. When these cells are injected into mice with heart damage, they migrate to the damaged tissue and differentiate into cardiac muscle cells.

Epstein and colleagues argue that Spoc cells are more likely to be precursors to cardiomyocytes than to be some other type of skeletal muscle stem cell. This is based on an absence of protein markers for skeletal muscle cells in Spoc cells, as well as the fact that Spoc-derived cells display spontaneous rhythmic beating and express cardiac markers, whether they are grown in a test tube or have migrated to injured hearts in study mice.

The authors can't say why skeletal muscle would harbor cardiac stem cells, but for now, the Spoc cells provide a valuable tool for studying heart cell differentiation. And with time, they might prove an important resource for developing cell-based therapies for heart disease.

###

Citation: Winitsky SO, Gopal TV, Hassanzadeh S, Takahashi H, Gryder D, et al. (2005) Adult murine skeletal muscle contains cells that can differentiate into beating cardiomyocytes in vitro. PLoS Biol 3(4): e87 .


'"/>

Source:PLoS Biology


Related biology news :

1. HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs
2. Implanted Devices Detect High-Risk Heart Failure Patients
3. Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments
4. Special Imaging Study Shows Failing Hearts Are Energy Starved
5. Stem Cell Research Shows Potential for Replacing Tissue Damaged in Heart Attacks
6. Male Combat Veterans Rank High In Heart Disease Risk
7. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
8. Researchers Find Drug May Give Some Cardiac Protection 24 Hours After Heart Attack
9. Heart-healthy compound in chocolate identified
10. Heart has enough oxygen to survive hypothermia, CPR crucial
11. Heart smart: new drug improves blood flow
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/5/2018)... ... 2018 , ... The new program allows 3rd ... innovative solutions for which high-speed imaging is a necessary albeit challenging component. , ... and instrumentation, allowing partner companies to dedicate their resources on their core strengths ...
(Date:11/27/2018)... ... November 26, 2018 , ... uBiome, the ... of the website IBDwatch and Gastroenterology Fellow at the University of Louisville, to ... around the world, Dr. Wuerth will bring to uBiome knowledge and research on ...
(Date:11/27/2018)... ... ... is a competitive Hunter-Jumper owned by Lisa Companioni Smith. In 2014, Anthony suffered a ... and Lisa was told he would never jump again and that she’d be lucky if ... the expert opinion of veterinarian and surgeon, Dr. Ruth-Anne Richter of Brandon Equine Medical ...
Breaking Biology News(10 mins):
(Date:12/13/2018)... ... December 11, 2018 , ... Researchers ... can use to quickly detect Clostridium difficile (C. diff), a dangerous and sometimes ... handheld device that can be used onsite in doctor’s offices and nursing homes, ...
(Date:12/5/2018)... SAN DIEGO (PRWEB) , ... December 05, 2018 , ... ... Itzkowich, introduces an all-new, how-to guide with his “The Referral Playbook: How to ... Itzkowich, 100% of the book proceeds will go to the Alzheimer’s Foundation of America ...
(Date:11/28/2018)... CALIF. (PRWEB) , ... November 28, 2018 , ... Earlier ... about Italian cuisine, as well as experience the height of truffle season. ... delicious food and pristine countryside. Staying in the exclusive Black Truffle Lodge in the ...
(Date:11/20/2018)... (PRWEB) , ... November 20, 2018 , ... Each year ... 30 Under 30 list which highlights outstanding performance by individuals under 30 years of ... wide range of fields from Sports and Entertainment to Venture Capital and Science. ...
Breaking Biology Technology: