Navigation Links
Heart failure: Intervention possibilities from imaging programmed cell loss

Using a nuclear medicine technique and molecular imaging to "see" programmed cell loss—the body's normal way of getting rid of unneeded or abnormal cells—may help in early identification of those individuals who are at risk of developing heart failure, say researchers in the April Journal of Nuclear Medicine.

"Our study indicates that it is feasible to noninvasively identify cell loss—or apoptosis—in heart failure patients using annexin A5 imaging," explained Leo Hofstra, director of cardiovascular imaging at the University Hospital of Maastricht in the Netherlands. "Such a strategy may offer a new possibility for studying interventions to minimize damage to the heart muscle," he added. "This research is significant since cell loss is potentially reversible and earlier intervention could delay the development of cardiomyopathy or heart muscle disease," noted Hofstra. He indicated that additional research is needed since the study was performed on a small group of heart patients.

"Heart failure is a major health care problem," said Hofstra, "and researchers are looking at novel ways to improve patient care." With heart failure, a person's heart no longer pumps sufficient blood to the body's organs. Nearly 5 million Americans are living with heart failure—a long-term condition that tends to gradually worsen—and 550,000 new cases are diagnosed each year.

Researchers attached a radioactive substance to annexin A5, a protein that binds to dying cells, said Hofstra. They then used nuclear imaging that produces three-dimensional computer-reconstructed images to reveal information about both structure and function to measure the amount of annexin A5 absorbed. Annexin A5 bound to the damaged heart muscle. "We discovered that higher uptake was uptake with a worse outcome. Cell death is one of the biological events that worsens left ventricular events," said Hofstra.

"Our results indicate that heart muscle cell death is an active and ongo ing process in heart failure, and that annexin imaging could possibly guide treatment for heart patients and be used to determine whether a treatment was working," said Hofstra, co-author of "Noninvasive Detection of Programmed Cell Loss with 99mTc-Labeled Annexin A5 in Heart Failure." He anticipates that this research would spur development of new drugs for heart disease.


'"/>

Source:Society of Nuclear Medicine


Related biology news :

1. HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs
2. Implanted Devices Detect High-Risk Heart Failure Patients
3. Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments
4. Special Imaging Study Shows Failing Hearts Are Energy Starved
5. Stem Cell Research Shows Potential for Replacing Tissue Damaged in Heart Attacks
6. Heart repair gets new muscle
7. Male Combat Veterans Rank High In Heart Disease Risk
8. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
9. Researchers Find Drug May Give Some Cardiac Protection 24 Hours After Heart Attack
10. Heart-healthy compound in chocolate identified
11. Heart has enough oxygen to survive hypothermia, CPR crucial
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/20/2016)... and GENEVA, Dec, 20, 2016   ... data sensor technology, and STMicroelectronics (NYSE: ... spectrum of electronics applications, announced today the launch ... kit for biometric wearables that includes ST,s compact ... Valencell,s Benchmark™ biometric sensor system. Together, ...
(Date:12/16/2016)... 16, 2016 The global wearable medical device market, in ... 2021 from USD 5.31 billion in 2016, at a CAGR of ... ... technological advancements in medical devices, launch of a growing number of ... connectivity among healthcare providers, and increasing focus on physical fitness. ...
(Date:12/15/2016)... , Dec. 15, 2016 Advancements ... experience, health wellness and wellbeing (HWW), and ... in three new passenger vehicles begin to ... gesture recognition, heart beat monitoring, brain wave ... facial monitoring, and pulse detection. These will ...
Breaking Biology News(10 mins):
(Date:1/12/2017)... ... January 12, 2017 , ... ... VTI, Vertebral Technologies, Inc., announces the successful outcome of the first lumbar ... 2016, VTI (Vertebral Technologies, Inc.) has partnered with Mexico-based medical product company ...
(Date:1/12/2017)... , January 12, 2017 ... the world,s biggest facility for producing mycorrhizae. The Centre ... nutrient tapping potential of mycorrhizae and developed a technology ... ... http://mma.prnewswire.com/media/456932/PRNE_TERI_Logo.jpg) The TERI facility has ...
(Date:1/11/2017)... , ... January 11, 2017 , ... ... Clinical Cancer Research show early promise of the investigational anti-cancer agent tucatinib (formerly ... median 5 previous treatment regimens. Twenty-seven percent of these heavily pretreated patients saw ...
(Date:1/11/2017)... , ... January 11, 2017 , ... ... year and costing healthcare systems more than $23.7 billion, healthcare systems are ... , Among the most common sepsis-causing pathogens are bacteria and the yeast ...
Breaking Biology Technology: