Navigation Links
Heart failure: Intervention possibilities from imaging programmed cell loss

Using a nuclear medicine technique and molecular imaging to "see" programmed cell loss—the body's normal way of getting rid of unneeded or abnormal cells—may help in early identification of those individuals who are at risk of developing heart failure, say researchers in the April Journal of Nuclear Medicine.

"Our study indicates that it is feasible to noninvasively identify cell loss—or apoptosis—in heart failure patients using annexin A5 imaging," explained Leo Hofstra, director of cardiovascular imaging at the University Hospital of Maastricht in the Netherlands. "Such a strategy may offer a new possibility for studying interventions to minimize damage to the heart muscle," he added. "This research is significant since cell loss is potentially reversible and earlier intervention could delay the development of cardiomyopathy or heart muscle disease," noted Hofstra. He indicated that additional research is needed since the study was performed on a small group of heart patients.

"Heart failure is a major health care problem," said Hofstra, "and researchers are looking at novel ways to improve patient care." With heart failure, a person's heart no longer pumps sufficient blood to the body's organs. Nearly 5 million Americans are living with heart failure—a long-term condition that tends to gradually worsen—and 550,000 new cases are diagnosed each year.

Researchers attached a radioactive substance to annexin A5, a protein that binds to dying cells, said Hofstra. They then used nuclear imaging that produces three-dimensional computer-reconstructed images to reveal information about both structure and function to measure the amount of annexin A5 absorbed. Annexin A5 bound to the damaged heart muscle. "We discovered that higher uptake was uptake with a worse outcome. Cell death is one of the biological events that worsens left ventricular events," said Hofstra.

"Our results indicate that heart muscle cell death is an active and ongo ing process in heart failure, and that annexin imaging could possibly guide treatment for heart patients and be used to determine whether a treatment was working," said Hofstra, co-author of "Noninvasive Detection of Programmed Cell Loss with 99mTc-Labeled Annexin A5 in Heart Failure." He anticipates that this research would spur development of new drugs for heart disease.


'"/>

Source:Society of Nuclear Medicine


Related biology news :

1. HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs
2. Implanted Devices Detect High-Risk Heart Failure Patients
3. Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments
4. Special Imaging Study Shows Failing Hearts Are Energy Starved
5. Stem Cell Research Shows Potential for Replacing Tissue Damaged in Heart Attacks
6. Heart repair gets new muscle
7. Male Combat Veterans Rank High In Heart Disease Risk
8. Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
9. Researchers Find Drug May Give Some Cardiac Protection 24 Hours After Heart Attack
10. Heart-healthy compound in chocolate identified
11. Heart has enough oxygen to survive hypothermia, CPR crucial
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... Janice Kephart , former 9/11 ... Partners, LLP (IdSP) , today issues the following ... March 6, 2017 Executive Order: Protecting the ... be instilled with greater confidence, enabling the reactivation ... applications are suspended by until at least July ...
(Date:4/18/2017)... SUNNYVALE, Calif. , April 18, 2017  Socionext Inc., a ... prototype of a media edge server, the M820, which features the ... face recognition software provided by Tera Probe, Inc., will be showcased ... and at the NAB show at the Las Vegas ... ...
(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... AMRI, a global contract ... to improve patient outcomes and quality of life, will now be offering its ... attributed to new regulatory requirements for all new drug products, including the finalization ...
(Date:10/11/2017)... Alto, CA, USA (PRWEB) , ... October 11, 2017 , ... ... set to take place on 7th and 8th June 2018 in San Francisco, CA. ... policy influencers as well as several distinguished CEOs, board directors and government officials from ...
(Date:10/11/2017)... Austin, TX (PRWEB) , ... October 11, 2017 ... ... in August compared the implantation and pregnancy rates in frozen and fresh ... the contribution of progesterone and maternal age to IVF success. , After comparing ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO of ... Rotary Club. The event entitled “Stem Cells and Their Regenerative Powers,” ... Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. Hanson, ...
Breaking Biology Technology: