Navigation Links
Health costs soar as 60 million Americans classed as obese

A new method for manipulating macromolecules has been developed by researchers at the University of Illinois at Urbana-Champaign. The technique uses double-stranded DNA to direct the behavior of other molecules.

In previous DNA nanotechnology efforts, duplex DNA has been used as a static lattice to construct geometrical objects in three dimensions. Instead of manipulating DNA alone into such shapes, the researchers are using DNA to control the folding and resulting structure of RNA. Eventually, they envision building supramolecular machines whose inner workings are governed by twisted strands of DNA.

In a paper that has been accepted for publication in the Journal of the American Chemical Society, and posted on its Web site, Silverman and graduate student Chandrasekhar Miduturu begin with a piece of unfolded RNA. Through specific chemical reactions, they attach two strands of DNA, each resembling one side of a ladder. The two DNA strands spontaneously bind together, then the researchers add magnesium ions to initiate folding of the RNA.

"Folding of the RNA structure competes with formation of the DNA constraint until a chemical balance is reached," Silverman said. "In some cases, the DNA is like a barnacle, just stuck onto the RNA without perturbing its structure. In other cases, the DNA changes the RNA structure. We can predict which situation will occur based on the shape of the RNA and on the attachment points of the DNA constraint."

In cases where the normal RNA shape and the DNA constraint cannot co-exist simultaneously, the balance between competing RNA and DNA structures is controlled by the concentration of magnesium ions, Silverman said.

In work not yet published, the researchers have also shown that the effects of the DNA constraint on the RNA structure can be modulated by external stimuli such as DNA oligonucleotide strands, protein enzymes and chemical reagents.

While Silverman and Miduturu are currently usi
'"/>

Source:


Page: 1 2

Related biology news :

1. BioMed Central welcomes the new National Institutes of Health public access policy
2. OneWorld Health drug receives Orphan designation from U.S. and European regulatory agencies
3. Going To Extremes To Improve Human Health
4. Patient-choice C-section rate rises 36%: HealthGrades study
5. Grand Challenges in Global Health initiative funds Yale project
6. Health benefits of a Christmas brandy
7. Health of coral reefs detected from orbit
8. Health of Acehnese reefs in the wake of the tsunami shows human impacts more harmful
9. Healthy coral reefs of Madagascar resisting damage from climate change
10. Health Canada approves cold and flu medicine
11. Mailman School of Public Health researchers report blood DNA can be early predictor of liver cancer
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Health costs soar million Americans classed obese

(Date:10/15/2014)... a non-traditional biophysics textbook and it describes how life ... of discovery into biological systems and provides an understanding ... is about how our genes make proteins that control ... cells in an organism. It quantifies the principles of ... be found on both large and small scales. The ...
(Date:10/15/2014)... , Oct. 15, 2014 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market releases photos ... in Times Square on Monday October 13 th . ... David Tunnel and angel investor Mr. Chad A. ... , CEO of NXT-ID thanked his investors and employees "for their ...
(Date:10/14/2014)... new study published in Cancer Research shows ... and colon cancers—can promote the development of skin cancers ... and survival of sun-damaged skin cells. , Previously considered ... proteins called sirtuins that help regulate genomic stability and ... SIRT6 helps repair DNA damage, which can lead to ...
Breaking Biology News(10 mins):New book about life as seen from physics 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2
... Whether it's rice farming or rice research, very few of ... career in an industry that has been a foundation of ... want their children to be rice farmers, and even fewer ... vital importance to the region. , However, an innovative ...
... sound like Saturday cartoons: a strong-boned rat that can't ... the real hero is citrus juice. , Orange and ... long considered an unavoidable aging disease in which bones ... by Texas A&M University's Vegetable and Fruit Improvement Center ...
... more than 25 million people in sub-Saharan Africa, according ... a vaccine against the virus have achieved limited success. ... infection found widely in that region of Africa ?chancroid ... of HIV as much as 10-fold? , That may ...
Cached Biology News:A rice future for Asia 2Orange, grapefruit juice for breakfast builds bones in rats 2Vaccine shown effective against chancroid 2Vaccine shown effective against chancroid 3
(Date:10/25/2014)... This research report “Biodegradable Plastics Market ... Regenerated Cellulose, PCL), by Application (Packaging, Fibers, Agriculture, ... 2019”, defines and segments the global biodegradable plastics ... global volume and value. , Browse 75 Market ... Slides and in-depth TOC on “Biodegradable Plastics Market ...
(Date:10/25/2014)... A new way to produce engineered skin ... skin grafting technologies, it also speeds up the healing ... in the October issue of STEM CELLS Translational Medicine, ... that result from severe burns and chronic wounds. , ... elements. These wounds heal by contraction, with epithelization (the ...
(Date:10/25/2014)... and NEW YORK , Oct. ... ACCPD), formerly Access Pharmaceuticals, Inc. (ACCP), a biopharmaceutical ... it has implemented a 1-for-50 reverse split of ... trading on Friday, October 24, 2014. PlasmaTech,s common ... new CUSIP number 72754H109 and temporary ticker symbol ...
(Date:10/25/2014)... , Oct 24, 2014 Research and ... "Epigenetics Market by Product , Research Area & by ... to their offering. In this report, ... of products, research areas, and end users. The product ... are enzymes, instruments & consumables, kits, and reagents. The ...
Breaking Biology Technology:Biodegradable Plastics Market Projected to $3,476.87 Million by 2019 - Report by MarketsandMarkets 2Biodegradable Plastics Market Projected to $3,476.87 Million by 2019 - Report by MarketsandMarkets 3Biodegradable Plastics Market Projected to $3,476.87 Million by 2019 - Report by MarketsandMarkets 4New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 2New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 3PlasmaTech Biopharmaceuticals, Inc. Announces Reverse Stock Split, Ticker Change and Launches New Corporate Website 2Global Epigenetics (VLA, WBA, NBA, RTA, Rotary-Wing Aircraft) Market - Forecast to 2019 2Global Epigenetics (VLA, WBA, NBA, RTA, Rotary-Wing Aircraft) Market - Forecast to 2019 3
... research on an ongoing basis is the most effective ... many companies, the benefits of conducting marketing research and ... be at odds: , ,Marketing research can be ... , ,The traditional solution to this quagmire is to ...
... traveled to an event in Madison, Wis. that was organized ... was designed to bring together three geographic locations of high-technology ... ePrairies third eXtreme Networking event (but the first ... a methodology for dating where men and women come together ...
... market has been steadily advancing. People are starting to feel ... in spite of the gnawing reality that far too many ... will never return. Some US pundits are saying in four ... big trouble, with huge raising deficits and the ever-increasing trade ...
Cached Biology Technology:Talking Bout My Generation: The Evolution of Online Marketing Research 2Talking Bout My Generation: The Evolution of Online Marketing Research 3Mike Rosen Reviews - eXtreme Networking in Madison 2Mike Rosen Reviews - eXtreme Networking in Madison 3The Next Economy - Market Collapses Drive Long-Term Growth 2
Phospho-Btk (Tyr223) Antibody...
...
... to Ki67 - Proliferation Marker, prediluted ... related nuclear protein, expressed by proliferating cells ... cycle (G1, S, G2 and M phase). ... Ki67 antibodies are useful in establishing the ...
Request Info...
Biology Products: