Navigation Links
Healing the heart with bone marrow cells

Researchers at the McEwen Centre for Regenerative Medicine at Toronto General Hospital have discovered the 'SOS' distress signal that mobilizes specific heart repair cells from the bone marrow to the injured heart after a heart attack.

While it has long been known that bone marrow cells have the ability to clear the dead tissue after a heart attack, what has not been known until now is the critically important role of bone marrow adult stem cells in repairing a damaged heart, restoring its function and enhancing the growth of new blood vessels.

"These cells act like generals in a battlefield, explained Dr. Shafie Fazel, cardiac surgery resident at TGH, University of Toronto surgeon/scientist program fellow and lead author of the study entitled, "Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines," published today in The Journal of Clinical Investigation. "When damaged heart tissue sends out an 'SOS' distress signal, this subset of bone marrow cells mobilizes quickly and stimulates the growth of new blood vessels in the heart. This is the first step in repairing the heart and in preventing the vicious downward spiral of heart failure in which the heart progressively thins and dilates, eventually causing death." Despite advances in surgical procedures, mechanical assistance devices, drug therapy, and organ transplantation, more than half of patients with congestive heart failure die within five years of initial diagnosis.

"Cardiovascular diseases are the most important cause of mortality in Canada and the western world," said Dr. Ren-Ke Li, scientist at the McEwen Centre for Regenerative Medicine and Professor of Cardiovascular Surgery at the University of Toronto. "Each year, 70,000 Canadians suffer from a heart attack and many of them are left with crushing disabilities, mainly because the heart muscle is not able to regenerate after a heart attack. This study identifies the metho
'"/>

Source:University of Toronto


Page: 1 2 3

Related biology news :

1. Healing honey: The sweet evidence revealed
2. UCSD team discovers specialized, rare heart stem cells in newborns
3. Single stem cells from bone heal a broken heart
4. Python a hearty eater
5. Columbia study shows widely used artery clearing device does not help patients during heart attack
6. Researchers reveal secret of key protein in brain and heart function
7. Stem cell therapy successfully treats heart attack in animals
8. New defibrillator signals doctor of patients irregular heartbeat or device malfunction
9. Survival of heart patients on beta-blockers varies greatly with genetic variation
10. Chemical band-aid prevents heart failure in mice with muscular dystrophy
11. MicroRNA tweaks protein that controls early heart development
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Healing the heart with bone marrow cells

(Date:1/22/2015)... , Jan. 9, 2015 Valid S.A. ("Company") (BM&FBOVESPA: ... market in general the State of Washington,s ... for a new enrollment and central issuance system for driver,s ... The project planning and development will start in ...
(Date:1/22/2015)... 15, 2015  BellBrook Labs, a leader in high ... launch of a TR-FRET (time resolved Forster resonance ... Assay, a high throughput screening assay for glycosyltransferases ... allow for sensitive detection of hundreds of human ...
(Date:1/22/2015)... , Jan. 21, 2015  Analyst Report Issued by Small ... Brands report showed that planet-wide, transactions at merchants on the ... the total number of credit, debit, and prepaid cards reached ... were victims of fraudulent card usage in 2012, and credit ...
Breaking Biology News(10 mins):Valid USA Signs Contract For Washington Driver's License Issuance 2BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2
... inexpensive land along coastlines for vacation homes and tourist hotels. ... that threatens the very coral reefs attracting tourists in the ... Research Institute and colleagues find that bacteria on coral reefs ... in seawater increases. , "I set up a seawater system ...
... Garvan Institute, in collaboration with Spanish scientists, have formulated ... normal growth controls, which may have far-reaching implications for ... found large regions of DNA are 'switched off' in ... the Garvan Institute, says: "These large regions ?referred to ...
... multifaceted study involving the Kuna Indians of Panama, ... chemical compound that is, in part, responsible, for ... chocolate products. , The researchers, who are from ... of Duesseldorf, Germany; and Harvard Medical School, hope ...
Cached Biology News:Cancer cells suppress large regions of DNA by a reversible process that can be tackled 2Heart-healthy compound in chocolate identified 2
(Date:1/22/2015)... 2015 Controlled Substance Compliance Services (CSCS), ... companies check the legal requirements around using controlled substances ... , As their international operations expand and become ... solutions built as a result of the first phase ...
(Date:1/22/2015)... Jersey , 22 de enero de 2015  El Dr. ... hoy su llamada a nominaciones para 2015. Este prestigioso ... hecho, o tiene el potencial para hacer, contribuciones destacadas ... se aceptarán hasta el 15 de marzo de 2015 ...
(Date:1/22/2015)... , Jan. 22, 2015   GenoSpace , a precision medicine ... to enable the broad use of genomic, imaging and other ... appointment of Michelle Munson , CEO of Aspera, an ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 "We ...
(Date:12/24/2014)... 2014  United Therapeutics Corporation (NASDAQ: UTHR ) ... ) has submitted a pre-market approval application to the ... of Medtronic,s SynchroMed ® II implantable drug infusion ... United Therapeutics, Remodulin ® (treprostinil) Injection delivered intravenously ...
Breaking Biology Technology:Global Compliance Service for Controlled Substances to Expand to China 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4GenoSpace Expands Board with Appointment of Michelle Munson 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4
... Aug. 7 SyntheMed, Inc. (OTC Bulletin Board: SYMD), ... of anti-adhesion products, announced today that REPEL-CV Bioresorbable Adhesion ... National Association for Children,s Heart Disorders, Inc. Michelle L. ... to inform parents of children with congenital heart defects ...
... , BOTHELL, Wash., Aug. 7 SCOLR Pharma, ... for the three and six months ended June 30, 2009. ... President and CEO, said, "We continue to advance discussions with a ... potential partners have been committing resources to due diligence and preliminary ...
... EXTON, Pa., Aug. 7 Kensey Nash Corporation today ... distribution rights, along with the trademark, inventory and other ... line. Under the terms of the agreement, the Company ... OsseoFit distribution agreement. Pursuant to the agreement, following a ...
Cached Biology Technology:REPEL-CV(TM) Adhesion Barrier Receives Endorsement of Kids With Heart 2SCOLR Pharma, Inc. Reports Second Quarter 2009 Financial Results 2SCOLR Pharma, Inc. Reports Second Quarter 2009 Financial Results 3SCOLR Pharma, Inc. Reports Second Quarter 2009 Financial Results 4SCOLR Pharma, Inc. Reports Second Quarter 2009 Financial Results 5SCOLR Pharma, Inc. Reports Second Quarter 2009 Financial Results 6SCOLR Pharma, Inc. Reports Second Quarter 2009 Financial Results 7SCOLR Pharma, Inc. Reports Second Quarter 2009 Financial Results 8Kensey Nash Announces Agreement to Acquire Rights to OsseoFit Product 2Kensey Nash Announces Agreement to Acquire Rights to OsseoFit Product 3
Rad 50 Immunogen: c-terminal mRad 50 (604 amino acids). Storage: 4 C...
...
... Materials for 15-20 enhancements when used as directed, ... Enhancement System is designed to amplify the desired signal ... for evaluating proteins with low expression., ... to blocking the membrane; 1x solution; 250 ml, ...
Applications: Western blotting ...
Biology Products: