Navigation Links
Harnessing genomic research

Regeneration of spinal nerve cells, a new way to personalise breast cancer treatment, rapid near-patient diagnosis of meningitis, MRSA and Chlamydia and effective vaccines to protect against salmonella are all important applications to have benefited from a £30M research programme built around harnessing knowledge of the human and other genomes.

A key feature of this LINK Applied Genomics Programme has been effective collaboration between industry and academia aimed at accelerating the application of knowledge of genomics in biomedicine and healthcare.

The programme funded 21 projects covering diverse research areas. Highlights from the programme include:

Nerve tissue regeneration- During spinal cord injury the nerves that transmit information between the brain and the body are injured and fail to regrow. The loss of this communication leads to paralysis and loss of sensation. Scientists at King's College London and Oxford BioMedica are investigating a receptor which allows nerve cells to reform severed connections. Identifying the genes that contribute to this regeneration will allow the team to understand why damaged nerve cells are unable to repair themselves. The work could lead to ways of stimulating nerves to regrow and repair damaged connections.

Personalised cancer treatment- A large number of cancers are linked to mutations in a specific gene or biological pathway. Researchers from KuDOS pharmaceuticals, Imperial College London and the Gurdon Institute, Cambridge are exploring ways to identify molecular signatures resulting from the loss of specific gene function in breast cancers that will correlate with susceptibility to a new anti-cancer drug being developed by KuDOS. The drug involved has the potential to kill tumour cells without affecting normal cells, so avoiding the side effects of hair-loss and nausea that often result from existing therapies. The genes and biological pathway under investigation are in volved in hereditary breast and ovarian cancers and have also been linked to other types of cancers.

Rapid diagnosis of infectious diseases?/B> Scientists at the Universities of Bath and Glasgow, with colleagues from Stobhill Hospital and Atlas Genetics Ltd are miniaturising established molecular techniques and combining them with novel assays to develop a hand-held 'chip' that will allow doctors to identify specific bacteria in patient samples. In the future this chip could be used to for rapid diagnosis of dangerous diseases such as MRSA infection and bacterial meningitis, where fast confirmation is critical, or for potentially catastrophic but widespread and non-symptomatic infections such as that caused by Chlamydia.

Vaccine against salmonella?/B> A team investigating the microbial genes important for the survival and growth of the salmonella pathogen during infection is using this knowledge to generate mutant bacterial strains that may be useful as vaccines. Experiments under way have shown several mutant bacterial strains to be highly effective as vaccines. In comparative studies one of the new strains had similar efficacy to that conferred by the current vaccine 'gold-standard' strain. Scientists from the Universities of Cambridge, Newcastle and Oxford and University College London have been working with their partner Arrow Therapeutics to combat this costly and dangerous livestock and human disease.

The highlights of the research programme are being presented to Parliamentarians and business leaders at a reception in London on the evening of 10 November. The programme was sponsored by the Biotechnology and Biological Sciences Research Council (BBSRC), the Department of Trade and Industry (DTI) and the Medical Research Council (MRC).


'"/>

Source:Biotechnology and Biological Sciences Research Council


Related biology news :

1. Harnessing microbes, one by one, to build a better nanoworld
2. Mayo Clinic Cancer Center: Harnessing the measles virus to attack cancer
3. Enzyme shown to help protect genomic stability
4. New comparative toxicogenomics database
5. Scientists document complex genomic events leading to the birth of new genes
6. Study of genomic DNA leads to new advances in cancer diagnostics
7. Measuring the impact of post-genomics on Mediterranean populations
8. Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
9. PHACCS, an online tool for estimating the structure and diversity of uncultured viral communities using metagenomic information
10. Owl genomics presents a HEPATOCHIP for diagnosis of non-alcoholic steatohepatitis
11. Enlisting genomics to understand flu evolution
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2016)... Feb. 2, 2016 Technology Enhancements Accelerate Growth of ... of the digital and computed radiography markets in ... and Indonesia (TIM). It provides ... size, as well as regional market drivers and restraints. ... market penetration and market attractiveness, both for digital and ...
(Date:2/1/2016)... , Feb. 1, 2016  Today, the first ... (AHA) announced plans to develop a first of its ... power of IBM Watson. In the first application of ... IBM (NYSE: IBM ), and Welltok will create ... health assessments with cognitive analytics, delivered on Welltok,s health ...
(Date:1/25/2016)...   Unisys Corporation (NYSE: UIS ) today announced ... International Airport, New York City , to help ... to enter the United States using passports ... pilot testing of the system at Dulles last year. The ... during January 2016. --> pilot testing of the ...
Breaking Biology News(10 mins):
(Date:2/3/2016)... WARRINGTON, Pa. , Feb. 3, 2016 /PRNewswire/ ... biotechnology company focused on developing aerosolized KL4 surfactant ... Board of Directors has approved an inducement award ... Craig Fraser , its newly appointed President and ... the Board,s Compensation Committee on February 1, 2016 ...
(Date:2/3/2016)... COPENHAGEN, Denmark , Feb. 3, 2016 ... stage biotechnology company that applies its innovative TransCon technology ... to present at an upcoming investor conference.Event:2016 Leerink Partners ... York, NY Date:  , Wednesday, February 10, 2016 Time:  ... --> www.ascendispharma.com . --> An audio ...
(Date:2/3/2016)... BRUNSWICK, N.J. , Feb. 3, 2016 /PRNewswire-USNewswire/ ... grants totaling more than $1 million for researchers ... are working on health-related research that demonstrates exciting ... this round of funding for the New Jersey ... for faculty members at these educational institutions— Princeton ...
(Date:2/3/2016)... ... February 03, 2016 , ... ProMIS ... potential targets (epitopes) specific to misfolded, propagating strains of Amyloid beta involved in ... antibody therapeutics for Alzheimer’s. , Following on from the first misfolded Amyloid beta ...
Breaking Biology Technology: