( f protein onto the bacteriophage which...)Harmless virus may hold key to more effective HIV drug discovery

f protein onto the bacteriophage, which was then coaxed into synthesizing the millions of mutational variants of Nef. The researchers then targeted this library, which they call an allelome, with a second library of small-molecule compounds in order to identify the specific compounds that could target the entire population of Nef mutational variants. The results suggest chemically simpler, more flexible compounds could better accommodate viral mutations.

The research is part of a UCI program aimed at expanding the anti-HIV drug arsenal. The program includes National Academy of Sciences member Larry Overman in the Department of Chemistry, who together with co-workers synthesized the small-molecules used in the study. New anti-HIV compounds are being tested by Dr. W. Ed Robinson, Jr. in the Department of Pathology.

Weiss and Olszewski have made their method freely available to the scientific research community. Olszewski is a fourth-year graduate student in the Weiss laboratory. The study was largely supported by a Young Investigator Award to Weiss from the Beckman Foundation.

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Source:University of California - Irvine


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