Navigation Links
Harmful chemicals may reprogram gene response to estrogen

New research shows that exposure to harmful chemicals and drugs during critical developmental periods early in life may actually "reprogram" the way certain genes respond to the female hormone estrogen. This genetic reprogramming may determine whether people with a genetic predisposition for a disease actually develop the disease.

The new research shows that when rats with a genetic predisposition to uterine tumors also receive an early-life exposure to diethylstilbestrol (DES), a synthetic form of estrogen linked to vaginal cancer, the incidence of uterine tumors rises to almost 100 percent. By comparison, slightly more than half of the unexposed animals, those having only the genetic defect, developed the uterine tumors.

DES is a drug that was prescribed for women from 1938 to 1971 to prevent miscarriages and premature deliveries. Daughters of women who used DES are at increased risk for reproductive tract abnormalities, pregnancy complications such as ectopic pregnancies and preterm deliveries, infertility, and a rare vaginal and cervical cancer called clear-cell adenocarcinoma. Other research conducted by NIEHS scientists indicates that women exposed to DES in utero have a higher risk of uterine fibroids.

The National Institute of Environmental Health Sciences, a component of the National Institutes of Health, provided funding to researchers at the University of Texas M.D. Anderson Cancer Center for the two-year study. The study results will be published in the May 2005 issue of the Proceedings of the National Academy of Sciences.

The discovery is important because it changes conventional thinking about the way in which genetic predisposition and things in the environment interact to increase disease risk. Until now, scientists thought that exposure to harmful agents in the environment caused damage to the gene. This study, however, indicates that an environmental agent can actually change or reprogram the gene so that it functions
'"/>

Source:NIH/National Institute of Environmental Health Sciences


Page: 1 2 3

Related biology news :

1. Harmful Bacterium Commonly Found in Poultry May Survive Refrigeration and Frozen Storage Combined
2. Research Reveals Functions Of Harmful Shellfish Pathogens
3. Harmful Algal Blooms monitored from space in Chile
4. Two chemicals boost immune cells ability to fight HIV without gene therapy
5. Pittsburgh researchers discover that certain chemicals in the blood may indicate brain injury
6. A silent pandemic: Industrial chemicals are impairing the brain development of children worldwide
7. Enhancing activity of marijuana-like chemicals in brain helps treat
8. Poplar trees redirect resources in response to simulated attack
9. A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020
10. Scientists solve structure of key protein in innate immune response
11. Mouse with designer liver has enhanced glucose tolerance, insulin response
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Harmful chemicals may reprogram gene response estrogen

(Date:3/23/2015)... , March 23, 2015   HOYOS Labs , ... company, today announced that the Company will demonstrate multiple ... enterprise and consumers at Connect:ID on March 23 through ... HOYOS Labs will highlight the IEEE Biometric Open Protocol ... ; and enterprise access control system. BOPS was invented ...
(Date:3/20/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market, announces its biometric payment ... products featured in 2015 "I Want That" International CES ... on the DIY Network.   DIY,s "I ... , site of the 2015 International CES for a ...
(Date:3/17/2015)... Emotient, the leader in facial expression ... availability of Emotient Analytics , the world,s ... facial expressions. The system analyzes videos of people ... services. It delivers audience response metrics - such ... derived from facial evidence of emotional states. Consumer ...
Breaking Biology News(10 mins):HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 2New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 4
... Protection Agency (EPA) has awarded nearly $2.5 million ... eight key environmental areas: monitoring and control of ... hazardous waste monitoring, water infrastructure, homeland security, nanotechnology ... received "proof of concept" awards from EPA, and ...
... -- Tufts University,s School of Arts and Sciences has ... that will house a Collaborative Cluster in Genome Structure ... will bring together experts in such areas as genome ... engineering to focus on "genome to organism" research to ...
... Researchers from Mahidol University have developed a rapid, ... The related report by Munkongdee et al, "Rapid ... the May 2010 issue of The Journal of ... caused by a genetic defect in the production of ...
Cached Biology News:EPA awards small businesses to develop new environmental technologies 2Tufts wins NCRR grant for Collaborative Cluster in Genome Structure and Developmental Patterning 2Tufts wins NCRR grant for Collaborative Cluster in Genome Structure and Developmental Patterning 3
(Date:3/26/2015)... March 26, 2015 Ale Gicqueau, Founder ... Director of Clinical Affairs at Align Technology, on “ ... the upcoming ACRP 2015 Global Conference and Exhibition on ... Utah. , During the poster presentation, Ale Gicqueau ... and running a Postmarket Registry, the requirements and resources ...
(Date:3/25/2015)... is one of the most attractive in the emerging ... a growing economy and increasing government investment in healthcare, ... Russian market is set to grow at twice the ... around 10-15% annually reaching an approximate market value of ... Green Cross provides total healthcare solutions that ...
(Date:3/25/2015)... , March 25, 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" ... as a result of recent discussions with certain shareholders ... of the Company, after dealing with certain matters including ... meeting of shareholders on March 26, 2015 (the "Meeting") ... election of directors will take place when the Meeting ...
(Date:3/25/2015)... The surging prevalence of internet use ... media growth, with over 50% of the world’s ... Insurance companies are making use of social media ... a diversity of their services and products. , ... networking services as part of sales and marketing, ...
Breaking Biology Technology:Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 2Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 3SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 2SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 3SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 4SQI Diagnostics Inc. Announces New Nominees to SQI Diagnostics Board and Adjournment of Meeting 5Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 2Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 3
... , , , EMERYVILLE, ... company, announced today that new research data will be delivered ... on Antimicrobial Agents and Chemotherapy (ICAAC) in San Francisco, CA ... a multi-institutional collaborative in vitro study of Adamas, ...
... , , ... MASI ), the inventor of Pulse CO-Oximetry(TM) and ... its Radical-7 and Rad-57 Pulse CO-Oximeters have achieved Airworthiness ... certification is a fundamental milestone that allows the U.S. ...
... LAUSANNE, Switzerland, September 3 Debiopharm Group, SA,(Debiopharm), ... focus on the development of prescription drugs that ... Sciences Award, to Dr Lluis,Quintana-Murci from the Institut ... the emerging field of evolutionary genetics of,infection. Funded ...
Cached Biology Technology:Adamas Pharmaceuticals to Present Data on Triple Combination Antiviral Drug Therapy for Drug-Resistant Influenza at 2009 ICAAC Annual Meeting 2Masimo Radical-7(R) and Rad-57(R) Pulse CO-Oximeters(TM) Awarded Airworthiness Release Certification by the United States Army 2Masimo Radical-7(R) and Rad-57(R) Pulse CO-Oximeters(TM) Awarded Airworthiness Release Certification by the United States Army 3Masimo Radical-7(R) and Rad-57(R) Pulse CO-Oximeters(TM) Awarded Airworthiness Release Certification by the United States Army 4The Debiopharm Life Sciences Award Goes to Dr Lluis Quintana-Murci for his Novel and Original Research on the Human Evolutionary Genetics of Infection 2The Debiopharm Life Sciences Award Goes to Dr Lluis Quintana-Murci for his Novel and Original Research on the Human Evolutionary Genetics of Infection 3
PCR System for increased fidelity, yield and length of PCR products. Amplifies targets up to 10 kb from human genomic DNA....
Request Info...
Immunogen: Heat inactivated bacterial cells of Salmonella enteriditis,paratyphi and typhimurium Storage: 4 C...
US Pharmacopoeia Purified-Water/Water-for-Injection Quality Water...
Biology Products: