Navigation Links
HIV vaccine trial breaks ground for future research

The results of the world's first phase 3 HIV vaccine efficacy trial are reported in the March 1 issue of The Journal of Infectious Diseases, now available online. Although the vaccine was ineffective in preventing HIV infection, the trial represents a landmark in the fight against HIV and offers the scientific community a foundation on which to build future trials.

The multi-centered trial, conducted in the United States and the Netherlands and completed in 2003, is described in two papers by the rgp120 HIV Vaccine Study Group, and Peter B. Gilbert and colleagues, which address the vaccine efficacy results and the immunologic responses of the study participants.

The vaccine, produced by VaxGen, was a recombinant construct of the HIV envelope glycoprotein, similar to the type of vaccine used to develop a vaccine for hepatitis B. The vaccine was tested in a double-blind, randomized study of healthy participants who did not use intravenous drugs. The volunteers were men who have sex with men or women at high risk for heterosexual transmission. The vaccine and placebo were given by injection seven times over 30 months and the participants were assessed for risk. At each visit the participants were tested for HIV infection, and for those who were positive, HIV-1 plasma RNA load and CD4 cell counts were monitored on a regular basis for 24 months after the initial diagnosis.

Of the 5,417 volunteers who were enrolled, 368 became infected during the study. The vaccine was found not to be effective in preventing HIV infection; infection rates among those who were given the vaccine and those who were given placebo were 6.7 percent and 7.0 percent, respectively. Of those who became infected during the study, pre-treatment viral loads were similar in the placebo and vaccine groups over their follow-up visits.

During analysis of various subgroups of the study population, a higher, though statistically insignificant, vaccine efficacy was found in the
'"/>

Source:Infectious Diseases Society of America


Page: 1 2

Related biology news :

1. Research advances quest for HIV-1 vaccine
2. A much-needed shot in the arm for HIV vaccine development
3. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
4. Gene vaccine for Alzheimers disease shows promising results
5. Influenza vaccine uses insect cells to speed development
6. Norovirus, AIDS vaccine and Hepatitis Virus
7. Live vaccines more effective against horse herpes virus
8. NIAID begins clinical trial of West Nile virus vaccine
9. Designing vaccines by computer
10. Wake Forest scientists find new combination vaccine effective against plague
11. New vaccine means bye-bye to bacteria in the lung
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: HIV vaccine trial breaks ground for future research

(Date:7/24/2014)... -- NXT-ID, Inc., (NXTD: OTCQB) a biometric authentication company focused on ... Wocket™, was recently the topic of  an interview on Boomer ... Pereira , CEO of NXT-ID, on July 9 th ... Gino Pereira explains how the Wocket will ... walks host Anita Finley through the step-by-step ...
(Date:7/23/2014)... , July 24, 2014 Pfenex Inc. (NYSE MKT: ... of 8,333,333 shares of its common stock at a price ... has granted the underwriters a 30-day option to purchase up ... public offering price. The shares are expected to begin trading ... symbol "PFNX". William Blair & Company, ...
(Date:7/23/2014)... early in life are at risk for developing ... new study, scientists have found that maltreatment affects ... for children,s long-term development. Previous studies focused on ... interacted with that child,s experiences in an effort ... new study, researchers were able to measure the ...
Breaking Biology News(10 mins):Boomer Times Gets to Know NXT-ID's Next Generation Wocket Smart Wallet; Practical, Secure and Easy to Use 2Boomer Times Gets to Know NXT-ID's Next Generation Wocket Smart Wallet; Practical, Secure and Easy to Use 3Boomer Times Gets to Know NXT-ID's Next Generation Wocket Smart Wallet; Practical, Secure and Easy to Use 4Pfenex Inc. Announces Pricing Of Initial Public Offering 2Stress tied to change in children's gene expression related to emotion regulation, physical health 2Stress tied to change in children's gene expression related to emotion regulation, physical health 3
... , This release is available in German . ... genes in the cells of their victim in order to ,reprogram, ... to live, making lots of new viruses instead. Luckily, ... is ensured by the cells, own sensors that recognise alien genetic ...
... and St. Andrews in the UK have found that the ... attractive they appear, and have found that diet may be ... be published in the December issue of Springer,s International ... a total of 54 Caucasian participants of both sexes were ...
... test to find undetected landmines. Students from the University ... when it comes into contact with chemicals leaked by buried ... solution that, when sprayed on to the ground, forms green ... say that the organism, which is cheap to produce, could ...
Cached Biology News:Study shows link between influenza virus and fever 2Skin color gives clues to health 2
(Date:7/24/2014)... materialise. Yet, scientists are making progress in devising ... such approach relies on quantum dotsa kind of ... field. A new study demonstrates that changing the ... with electrical impulses can help better control them. ... used as quantum information units, which would produce ...
(Date:7/24/2014)... 24, 2014 Research and Markets ... Culture Market 2014-2018" report to their offering.  ... culture is the in vitro growth of plant or ... studies, and biopharmaceutical production. Cell culture is a crucial ... instruments and cell culture consumables are necessary for the ...
(Date:7/24/2014)... MENLO PARK, Calif. , July 24, 2014 /PRNewswire/ ... million, seven-year contract with the National Institute of Allergy ... of Health, to conduct preclinical development of potential therapies ... development of drugs to treat HIV and AIDS and ... as well as microbicides for preventing sexual transmission of ...
(Date:7/24/2014)... Dallas, Texas (PRWEB) July 24, 2014 ... China Potassium Sulphate Industryā€¯ is a professional and ... The report introduces Potassium Sulphate basic information, ... structure and industry overview. This research covers the ... well as global industry analysis covering macroeconomic environment ...
Breaking Biology Technology:Global Cell Culture Market 2014-2018: Key Vendors are Becton, Dickinson and Co, EMD, GE Healthcare, Lonza Group, Sigma Aldrich and Thermo Fisher Scientific 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 4
... 2010, PRNewswire-Asia/ -- Tiens Biotech Group (USA), Inc. (the "Company" or ... , today announced financial results for the ... Revenue for the third quarter of 2010 was $10.4 million, compared ... the nine months ended September 30, 2010 was $30.0 million, compared ...
... Leaves for Brazil on State Visit -- LUSAKA, Zambia, November 15, 2010 ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... BitlyCB.alertResponse = function(data) { var s = ,; var first_result; // Results are keyed by longUrl, so we need ...
... infertility practice Carolina Conceptions welcomes new practice manager Nikki Duncan. ... team since the practice,s opening in 2006 and it is ... role of practice manager. Nikki is a graduate ... and previously served Carolina Conceptions as the Andrology Lab Manager. ...
Cached Biology Technology:Tiens Biotech Group (USA) Reports Third Quarter and Nine-Month Results 2Tiens Biotech Group (USA) Reports Third Quarter and Nine-Month Results 3Tiens Biotech Group (USA) Reports Third Quarter and Nine-Month Results 4Tiens Biotech Group (USA) Reports Third Quarter and Nine-Month Results 5Tiens Biotech Group (USA) Reports Third Quarter and Nine-Month Results 6Tiens Biotech Group (USA) Reports Third Quarter and Nine-Month Results 7Tiens Biotech Group (USA) Reports Third Quarter and Nine-Month Results 8Tiens Biotech Group (USA) Reports Third Quarter and Nine-Month Results 9President Banda Leaves for Brazil on State Visit 2President Banda Leaves for Brazil on State Visit 3President Banda Leaves for Brazil on State Visit 4President Banda Leaves for Brazil on State Visit 5President Banda Leaves for Brazil on State Visit 6President Banda Leaves for Brazil on State Visit 7President Banda Leaves for Brazil on State Visit 8
A camera based compact unit for high speed scanning of 2D barcoded tubes in a cluster rack. This reader has been designed to read both 96 and 48 tube rack configurations and be compatible with common...
... of VARIOMAG Magnetic Stirrers operate without any ... mechanical bearings, making VARIOMAG Magnetic Stirrers 100% ... inductive drive can be hermetically sealed, making ... This is why VARIOMAG Magnetic Stirrers are ...
PTFE/red rubber septum silver aluminum seal ,11 mm seal diam. ...
...
Biology Products: