Navigation Links
HIV vaccine takes different tack to boosting immune response

Researchers at Baylor College of Medicine (BCM) in Houston have reason to believe their unorthodox vaccine could one day help to prevent or control HIV infection, according to a study published in today's edition of Public Library of Science Medicine.

The study in mice boosted the immune response by removing the host's natural immune "brake." By unleashing the immune system's full potential in conjunction with conventional antiretroviral treatment, HIV could be treated more effectively or prevented altogether.

"A lot of vaccines work very well in dealing with some pathogens, but for HIV, the natural immune response usually fails," said Dr. Si-Yi Chen, associate professor at the Center for Cell and Gene Therapy at BCM and senior author of the study. "The natural immune regulator may not allow the immune system to respond to HIV infection strongly enough. So by relieving the 'brake,' we can hopefully overcome what is failing in the natural anti-HIV immune response."

In the study, funded by the National Institutes of Health, Chen and colleagues examined a molecule, SOCS1, which regulates how antigens are handled by dendritic cells, specialized white blood cells that activate the immune system.

The researchers previously found that dendritic cells in which the SOCS1 was turned off were more efficient at stimulating the body's immune cells.

Most immunization attempts to stimulate an immune response to HIV in the past have been disappointing, but Chen says his laboratory results hold promise to make current HIV vaccines work better. SOCS1 was found to be part of a pathway that not only controls the production of compounds (cytokines) that stimulate inflammation but also plays a critical role in regulating the potency of anti-HIV immune response. Dendritic cells in which SOSC1 was switched off were able to induce an effective long-term memory immune response to HIV.

"In mice, we were pretty consistent in activating anti-HIV i
'"/>

Source:Baylor College of Medicine


Page: 1 2

Related biology news :

1. Research advances quest for HIV-1 vaccine
2. A much-needed shot in the arm for HIV vaccine development
3. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
4. Gene vaccine for Alzheimers disease shows promising results
5. Influenza vaccine uses insect cells to speed development
6. Norovirus, AIDS vaccine and Hepatitis Virus
7. HIV vaccine trial breaks ground for future research
8. Live vaccines more effective against horse herpes virus
9. NIAID begins clinical trial of West Nile virus vaccine
10. Designing vaccines by computer
11. Wake Forest scientists find new combination vaccine effective against plague
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: HIV vaccine takes different tack boosting immune response

(Date:12/17/2014)... Valencell, a leader in performance biometric data sensor technology, ... such as Intel, Jabra, Atlas, and Scosche to develop ... products will be showcased at CES 2015, taking place ... "Our partners choose PerformTek biometrics, because ...
(Date:12/17/2014)... DENVER , Dec. 16, 2014  Automation is fundamentally ... evident than at international borders. Over the past decade, ... veteran travelers to self process through border control via ... increasing number of airports, seaports, and land borders across ...
(Date:12/11/2014)... Research and Markets , ... announced the addition of the "Biometrics Market in ... One major trend emerging in this market ... it is important to upgrade biometric solutions to the ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... outbreaks, wildfire, and forest dieback, may adversely affect people ... The U.S. Geological Survey led a new ... "ecological thresholds" in North America. The report, which was ... authored by a team of federal and academic climate ...
... expert David S. Rose will present a lecture at ... You Think You Know...Is Wrong: How New Technologies and ... As part of the Heath Lecture Series at ... will discuss the latest technologies and concepts that are ...
... YORK, January 16, 2009 - Researchers at the University of ... adult beta cells have the ability to replicate with the ... was led by Andrew F. Stewart, M.D., a Professor of ... at the University of Pittsburgh School of Medicine. The ...
Cached Biology News:David Rose to present Howe School lecture on new technologies and business models, Jan. 29 2JDRF-funded researchers discover proteins regulating human beta cell replication 2
(Date:1/22/2015)... 22, 2015 Selexis SA, a serial ... Cell Banks (RCBs) used for drug discovery to commercial ... will include Next-Generation Sequencing (NGS) data packages. ... biologic manufacturing by ensuring the integrity of the gene, ...
(Date:1/22/2015)... Medical Systems (NYSE: VAR ), world leader in ... to sustainability with inclusion on a prestigious list of the ... equipment company among the Corporate Knights Global 100 Most Sustainable ... Davos, Switzerland . "We ...
(Date:12/24/2014)...  United Therapeutics Corporation (NASDAQ: UTHR ) announced ... has submitted a pre-market approval application to the U.S. ... Medtronic,s SynchroMed ® II implantable drug infusion system ... Therapeutics, Remodulin ® (treprostinil) Injection delivered intravenously to ...
(Date:12/24/2014)... 2014 “Preparative & Process Chromatography ... Consumables (Columns, Solvents, Buffers, Valves, Guages, Seals), Accessories, ... - Forecasts to 2019” provides a detailed overview ... market trends, and strategies impacting the preparative and ...
Breaking Biology Technology:Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Varian Honored Among World's 100 Most Sustainable Corporations 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4
... announced that it has entered into agreement with ... generated by 100 percent,renewable energy resources, through IPL,s ... of fossil-fueled power generation, this,program will better enable ... BST becomes the third-largest customer to participate in ...
... objective of the,Alliance is to improve patient care ... marketplace. To celebrate the Alliance, a symposium ... with noted speakers from industry, government,entrepreneurs, venture capitalists ... Gesellschaft. The alliance will take advantage of ...
... in Pioneering Field, BETHESDA, Md., Sept. 10 ... of an ownership interest in,ClinResearch GmbH, a global ... adaptive, clinical trials. Headquartered in Cologne, Germany,with more ... 80,adaptive programs over the past seven years. ClinResearch,s ...
Cached Biology Technology:BioStorage Technologies Becomes Green Powered through the Use of 100% Certified Renewable Energy 2BioStorage Technologies Becomes Green Powered through the Use of 100% Certified Renewable Energy 3BioStorage Technologies Becomes Green Powered through the Use of 100% Certified Renewable Energy 4'Alliance for Medical Devices, Instrumentation and Diagnostics' formed between Fraunhofer Center for Manufacturing Innovation and Boston University 2United BioSource Acquires Interest in Leading Adaptive Design Technology Service Provider 2
No description available in Ensembl Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
No description available in Ensembl. Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
12(S)-HETE-d8 is used as an internal standard for the quantification of 12(S)-HETE by stable isotope dilution mass spectrometry....
...
Biology Products: