Navigation Links
HIV exploits competition among T-cells

A new HIV study shows how competition among the human immune system's T cells allows the virus to escape destruction and eventually develop into full-blown AIDS. The study, which employs a computer model of simultaneous virus and immune system evolution, also suggests a new strategy for vaccinating against the virus ?a strategy that the computer simulations suggest may prevent the final onset of AIDS.

The research, which is slated for publication in Physical Review Letters, is available online at http://arxiv.org/abs/q-bio.PE/0610018.

"Competition among T cells exerts a small influence for most diseases, but it's fatal for HIV," said study co-author Michael Deem, Rice University's John W. Cox Professor in Biochemical and Genetic Engineering and professor of physics and astronomy.

The new computer model, created by Deem and Guanyu Wang, now an assistant professor of physics at George Washington University, is the first to accurately reproduce all three stages of HIV infection. The first is marked by an initial spike in virus production that's immediately followed by dramatic drop as the immune system recognizes the threat, mounts a defense and destroys most of the invading viruses. The second phase is a long period of clinical latency that can last up to 10 years. In this phase, a small amount of virus mutates fast enough to escape initial detection and continues to mutate over time. The third phase, AIDS, occurs when the virus has changed so much that the body's T cells are no longer effective at keeping it in check.

Deem and Wang's computer model accurately describes all three phases of HIV infection by incorporating a key component: competition among T cells. The model includes two forms of competition. The first form leads to a phenomenon known as deceptive imprinting, or original antigenic sin. Original antigenic sin is the tendency for memory immune cells produced in response
'"/>

Source:Rice University


Page: 1 2 3

Related biology news :

1. Neandertal femur suggests competition with hyenas and a shift in landscape use
2. Birth rate, competition are major players in hominid extinctions
3. Variation in womens X chromosomes may explain differences among individuals, between sexes
4. Disease diagnosis, biodefense among UH chemical research projects
5. HIV drug resistance increasing in UK and among highest in the world
6. Why we give: New study finds evidence of generosity among our early human ancestors
7. Alcoholism, smoking and genetics among Plains American Indians
8. Genetic and environmental influences on alcohol consumption among rhesus monkeys
9. Skin disease common among Hispanic farmworkers in North Carolina, research shows
10. Cell barrier shows why bird flu not so easily spread among humans
11. Higher risk for cervical cancer seen among women infected with multiple HPV types
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: HIV exploits competition among cells

(Date:7/23/2014)... habit of getting tangled and forming knots. Scientists study ... to disentangle them (e.g. useful for gene sequencing techniques). ... Studies (SISSA) in Trieste and his team have been ... and their dynamics. In their latest paper, just published ... with Marco Di Stefano, first author and PhD student ...
(Date:7/23/2014)... available in German . ... for orientation, some of which might be very different ... polarization pattern produced by sunlight in the atmosphere to ... Planck Institute for Ornithology in Seewiesen, Germany, and Queen,s ... a night active mammal, the greater mouse-eared bat, has ...
(Date:7/23/2014)... Currently, no cure exists for Alzheimer,s disease, the ... Americans. But scientists are now reporting new progress ... cancer treatment, that shows promise as a potential ... ACS, Journal of Medicinal Chemistry . , ... that in a healthy brain, the protein known ...
Breaking Biology News(10 mins):Bats use the evening sky's polarization pattern for orientation 2
... Scientists from the Universit de Montral and McGill University ... chemical reactions within the human body, to become highly ... a new study published in The Journal of ... an enzyme structure," says Joelle Pelletier, a professor at ...
... nearly 50 years, a population of a nearly extinct ... Forest,s San Jacinto Wilderness. Biologists from the U.S. Geological ... and scientists from the San Diego Natural History Museum ... rare mountain yellow-legged frog in the San Jacinto Wilderness ...
... University of British Columbia researchers are part of an ... land plants, a step they hope will lead to ... ultimately boost conservation efforts. Barcodes based on portions ... on products have already emerged as a viable ...
Cached Biology News:Biologists rediscover endangered frog population 2Biologists rediscover endangered frog population 3Biologists rediscover endangered frog population 4UBC researchers help push for standard DNA barcodes for plants 2
(Date:7/22/2014)...   BioTE Medical , a leading provider ... pellets, today announced the addition of Dr. ... Rouzier is joining the BioTE Medical Advisory Board ... Rouzier was residency trained in Family Medicine and ... certified emergency physician still practicing at a large ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 CTD Holdings, ... the pharmaceutical, medical device, cosmetics, and other markets, announced ... with a group of qualified private investors led by ... , The transaction involved the signing of ... 1,725,000 shares of Common Stock at a price per ...
(Date:7/22/2014)... Rice Lake Weighing Systems ... NCSL International Workshop and Symposium July 28-31 in ... pressure instrumentation, OIML M1 weights, precision lab weights, ... sets, Essential Weights™. , NCSL International was formed ... solving the common problems faced by measurement and ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 Two new ... Board of Directors at its annual Shareholders Meeting on ... Information Officer of The PFM Group, and Stephen T. ... Center also announced the election of Michael A. DiPiano, ... Vice Chair and Richard P. Jaffe, Esq., of Duane ...
Breaking Biology Technology:Dr. Neal Rouzier Joins BioTE Medical 2Dr. Neal Rouzier Joins BioTE Medical 3CTD Holdings Closes $1.725 Million Private Placement 2CTD Holdings Closes $1.725 Million Private Placement 3Rice Lake Weighing Systems Showcases Metrology Solutions for the 2014 NCSL International Workshop & Symposium 2Two New Members Elected to University City Science Center Board of Directors 2Two New Members Elected to University City Science Center Board of Directors 3
... average 2006 super bowl commercial is unattainable for most ... for small business. , ,Using an Internet-based advertising agency ... a comprehensive TV advertising campaign in less than a ... You can purchase a pre-packaged ad from their ad ...
... University of Wisconsin-Madison's undergrad engineering contest was swept this ... solar energy collector that concentrates the sun's rays. , ... Friday in both the Schoofs Prize for Creativity and ... the mirrors that many current solar systems use to ...
... Quad Graphics, a printer of magazines, catalogs, books, direct ... tools for clients into a new business unit called ... Jaeger, who also serves as Quad Graphics' vice president ... QuadSystems is backed by the capabilities of 260 corporate ...
Cached Biology Technology:Local TV advertising - Super Bowl vs. super bargain 2Local TV advertising - Super Bowl vs. super bargain 3Local TV advertising - Super Bowl vs. super bargain 4Concentrated solar energy project wins Innovation Days prizes 2
... microRNA expression profiling and built on ... on-chip synthesis platform. These microarrays are ... microRNA Expression Profiling Service. ... Microarray contains all known maize microRNAs ...
... Agilent 6850 Networked GC is an excellent choice ... of a standard dual-channel GC, this one-channel workhorse ... in the space of one. You get all ... GC analyses in an instrument that has the ...
... The 6820 GC system combines world-class ... Chemical QA/QC software, Agilents world-renowned support and ... consumables and supplies--a combination that lets you ... decisions based on dependable data. The Agilent ...
... In the six short years since publication ... John Walkers widely acclaimed Protein Protocols Handbook, ... in protein biochemistry. In recognition of the ... the rapid evolution of new methodologies directed ...
Biology Products: