Navigation Links
HIV exploits competition among T-cells

A new HIV study shows how competition among the human immune system's T cells allows the virus to escape destruction and eventually develop into full-blown AIDS. The study, which employs a computer model of simultaneous virus and immune system evolution, also suggests a new strategy for vaccinating against the virus ?a strategy that the computer simulations suggest may prevent the final onset of AIDS.

The research, which is slated for publication in Physical Review Letters, is available online at http://arxiv.org/abs/q-bio.PE/0610018.

"Competition among T cells exerts a small influence for most diseases, but it's fatal for HIV," said study co-author Michael Deem, Rice University's John W. Cox Professor in Biochemical and Genetic Engineering and professor of physics and astronomy.

The new computer model, created by Deem and Guanyu Wang, now an assistant professor of physics at George Washington University, is the first to accurately reproduce all three stages of HIV infection. The first is marked by an initial spike in virus production that's immediately followed by dramatic drop as the immune system recognizes the threat, mounts a defense and destroys most of the invading viruses. The second phase is a long period of clinical latency that can last up to 10 years. In this phase, a small amount of virus mutates fast enough to escape initial detection and continues to mutate over time. The third phase, AIDS, occurs when the virus has changed so much that the body's T cells are no longer effective at keeping it in check.

Deem and Wang's computer model accurately describes all three phases of HIV infection by incorporating a key component: competition among T cells. The model includes two forms of competition. The first form leads to a phenomenon known as deceptive imprinting, or original antigenic sin. Original antigenic sin is the tendency for memory immune cells produced in response
'"/>

Source:Rice University


Page: 1 2 3

Related biology news :

1. Neandertal femur suggests competition with hyenas and a shift in landscape use
2. Birth rate, competition are major players in hominid extinctions
3. Variation in womens X chromosomes may explain differences among individuals, between sexes
4. Disease diagnosis, biodefense among UH chemical research projects
5. HIV drug resistance increasing in UK and among highest in the world
6. Why we give: New study finds evidence of generosity among our early human ancestors
7. Alcoholism, smoking and genetics among Plains American Indians
8. Genetic and environmental influences on alcohol consumption among rhesus monkeys
9. Skin disease common among Hispanic farmworkers in North Carolina, research shows
10. Cell barrier shows why bird flu not so easily spread among humans
11. Higher risk for cervical cancer seen among women infected with multiple HPV types
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: HIV exploits competition among cells

(Date:12/17/2014)... Dec. 15, 2014  HITLAB SM announced today its ... confirm its adherence to current U.S. Food and Drug ... regulated smart device and smart phone application trials utilizing ... "HITLAB is determined to improve global healthcare ...
(Date:12/17/2014)... 16, 2014 Research and Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ... Chemical Sensor Market 2015-2019" report to their offering. ... One major trend upcoming in this market is the ... sensors help in recording of patient data for quick ...
(Date:12/15/2014)... Dec. 12, 2014 Research and Markets ( ... "Global Facial Recognition Market 2015-2019" report to their ... Facial recognition is a technology used for the ... facial feature of a person such as nose, jaw ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... the University of New Hampshire Glycomics Center have helped ... activity to a glycoprotein antibody that could ... or rheumatoid arthritis. The study, reported in a recent ... Jeffrey Ravetch of Rockefeller University. The work ...
... Most teenagers wouldnt have a clue what this scientific ... the protocol inside and out. When Andrew was 12, ... of Tennessee, was looking for an interesting science project ... popular brands of Easter egg dyes, Trigianos project soon ...
... HARBOR, N.Y. For more than 25 years, ... served as an established resource for researchers, students, and ... to process normal or diseased tissues for microscopic analysis. ... ( www.scionpublishing.com ), will remain as the leading source ...
Cached Biology News:Sugar linkage could lead to better treatment for autoimmune diseases 2DNA fingerprinting simplified 2Expanded histology methods book covers processing of animal, plant, and microbial tissues 2
(Date:1/22/2015)... MA (PRWEB) January 22, 2015 zFlo ... is pleased to announce an exciting product from a new ... motion analysis solutions over the past 15 years, with offerings ... Most recently, their 3D IMU system (inertial measurement unit), iSen, ...
(Date:1/22/2015)... January 22, 2015 Selexis SA, a ... Research Cell Banks (RCBs) used for drug discovery to ... Banks will include Next-Generation Sequencing (NGS) data ... de-risks biologic manufacturing by ensuring the integrity of the ...
(Date:1/22/2015)... , Jan. 22, 2015   Cypher Genomics, ... Sequenom, Inc. (NASDAQ: SQNM ), the ... agreement for next generation noninvasive prenatal tests (NIPT). ... interpretation technology, called Mantis™, to advance analysis of ...
(Date:1/22/2015)... , Jan. 22, 2015  Derma Sciences, Inc. (Nasdaq: ... focused on advanced wound care, announces that AMNIOEXCEL® ... have been added to the Premier, Inc. Regenerative ... opportunity for the AMNIOEXCEL® and AMNIOMATRIX® product lines, ...
Breaking Biology Technology:3D Motion Capture Just Got Easy 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5
... read this batch of headlines, you might conclude Wisconsin's economy ... hit home: GM, Delphi workers take buyouts" ,"About 260 at ... County loses bid as Honda picks Indiana site for plant." ... just as easily think the state economy is humming down ...
... Co. , the banking and payments technology subsidiary of ... of online loan software to the federally chartered savings ... with more than four million customers and over $62 ... products for its wholesale mortgage operation, ING Mortgage. ...
... the Chippewa Valley are vying for up to $10,000 in ... of public awareness as part of the 2006 "Create Your ... Area Economic Development Corporation . , ,From a total of ... invited to submit full business plans for the competition. As ...
Cached Biology Technology:Is Wisconsin's economy stronger, weaker, or just changing? 2Is Wisconsin's economy stronger, weaker, or just changing? 3Eau Claire business contest down to 7 applicants 2
Mouse/Rat WNK1 Affinity Purified Polyclonal Ab...
RayBio L Series 507: RayBio Label-based Antibody Array I (2 membranes) Class: Antibody Array Products Product Group: Antibody Array...
... The SYBR Safe photographic filter ... Gels and Blots) is ideal for ... the SYBR Safe DNA gel stain, ... that the SYBR Safe photographic filter ...
Mature rat whole blood (Sprague-Dawley, averaging 7-8 weeks of age, either sex) is collected at the time of slaughter and processed within 45 minutes. It is then filtered through gauze, pooled in an ...
Biology Products: