Navigation Links
HIV exploits competition among T-cells

A new HIV study shows how competition among the human immune system's T cells allows the virus to escape destruction and eventually develop into full-blown AIDS. The study, which employs a computer model of simultaneous virus and immune system evolution, also suggests a new strategy for vaccinating against the virus ?a strategy that the computer simulations suggest may prevent the final onset of AIDS.

The research, which is slated for publication in Physical Review Letters, is available online at http://arxiv.org/abs/q-bio.PE/0610018.

"Competition among T cells exerts a small influence for most diseases, but it's fatal for HIV," said study co-author Michael Deem, Rice University's John W. Cox Professor in Biochemical and Genetic Engineering and professor of physics and astronomy.

The new computer model, created by Deem and Guanyu Wang, now an assistant professor of physics at George Washington University, is the first to accurately reproduce all three stages of HIV infection. The first is marked by an initial spike in virus production that's immediately followed by dramatic drop as the immune system recognizes the threat, mounts a defense and destroys most of the invading viruses. The second phase is a long period of clinical latency that can last up to 10 years. In this phase, a small amount of virus mutates fast enough to escape initial detection and continues to mutate over time. The third phase, AIDS, occurs when the virus has changed so much that the body's T cells are no longer effective at keeping it in check.

Deem and Wang's computer model accurately describes all three phases of HIV infection by incorporating a key component: competition among T cells. The model includes two forms of competition. The first form leads to a phenomenon known as deceptive imprinting, or original antigenic sin. Original antigenic sin is the tendency for memory immune cells produced in response
'"/>

Source:Rice University


Page: 1 2 3

Related biology news :

1. Neandertal femur suggests competition with hyenas and a shift in landscape use
2. Birth rate, competition are major players in hominid extinctions
3. Variation in womens X chromosomes may explain differences among individuals, between sexes
4. Disease diagnosis, biodefense among UH chemical research projects
5. HIV drug resistance increasing in UK and among highest in the world
6. Why we give: New study finds evidence of generosity among our early human ancestors
7. Alcoholism, smoking and genetics among Plains American Indians
8. Genetic and environmental influences on alcohol consumption among rhesus monkeys
9. Skin disease common among Hispanic farmworkers in North Carolina, research shows
10. Cell barrier shows why bird flu not so easily spread among humans
11. Higher risk for cervical cancer seen among women infected with multiple HPV types
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: HIV exploits competition among cells

(Date:7/10/2014)... Intelligence today released forecasts from "The Global National eID ... for National Electronic ID (eID) programs will generate $54 billion ... number of National eID cards in circulation will double from ... with its vast population, will dominate the market representing nearly ... Europe trails a distant second at 11%. ...
(Date:7/10/2014)... for Basic Science (IBS), the main organization of the ... has announced that a group of researchers, led by ... in the field of optogenetics that can remotely control ... technology "OptoTrk" and it has succeeded with neuronal differentiation ... is that it requires only light to activate neuronal ...
(Date:7/10/2014)... even improve the state of fisheries resources in ... Mediterranean has deteriorated over the past 20 years. ... reported in the Cell Press journal Current ... stringent monitoring of Mediterranean fishing activities, better enforcement ... Mediterranean waters. , Their data show that the ...
Breaking Biology News(10 mins):National Electronic ID Programs Generate $54 Billion Between 2013 and 2018 with 3.5 Billion National eID Card Holders Worldwide 2New optogenetic tool for controlling neuronal signalling by blue light 2Mediterranean fish stocks show steady decline 2
... found a new way that DNA can carry out its ... mold used to cast a metal tool can also serve ... distinct functional roles. Professor Manolis Kellis and postdoctoral research ... the journal Genes & Development that in certain DNA sequences, ...
... E-Ticketing Solution from BIO-key and Advanced Public Safety ... Officer Risk, Reduces Cost and Increases ... Fla., Jan. 10 /PRNewswire-FirstCall/,-- BIO-key International, Inc. (OTC ... and wireless public safety solutions,and Advanced Public Safety ...
... Cold Spring Harbor, NY Cold Spring Harbor Laboratorys ... Joans Legacy: The Joan Scarangello Foundation to Conquer Lung ... cancer research involving a new class of genetic mutations ... lung cancer, the leading cause of cancer deaths in ...
Cached Biology News:MIT reports new twist in microRNA biology 2Missouri Police Department Introduces Electronic Traffic Citations 2Missouri Police Department Introduces Electronic Traffic Citations 3Missouri Police Department Introduces Electronic Traffic Citations 4Cold Spring Harbor Laboratory's lung cancer research program awarded $100,000 grant 2
(Date:1/15/2014)... Niagara Thermal Products is proud to announce that ... ("B3") as the critical thermal component supplier in support ... Corps of Engineers.  B3 has developed the only comprehensive ... destroys VOCs and other chemical pollutants, allergens and organic ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Cynvenio, a ... management through the genomic analysis of tumor cells in ... Finder™, a web-based cancer decision support application powered by ... with Cynvenio’s ClearID™ genomic test, Therapy Finder will provide ...
(Date:1/15/2014)... , Jan. 15, 2014 ­ RedBrick Health ... behavior change technology, today announces that EmblemHealth , ... and wellness company, is now providing the RedBrick Compass ... coaching program, to all of its members. EmblemHealth is ...
(Date:1/15/2014)... January 15, 2014 A study has been ... the Formula 1 track could help to tackle the problem ... (MAT), Stowhealth (a GP surgery based in Stowmarket) and academics ... Simplyhealth. Telemetry technology, which is inspired by equipment ...
Breaking Biology Technology:Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4
... the University of Pennsylvania demonstrates a more consistent and ... has promising applications in a variety of fields, and ... Physics. As explained in a recently published study, ... graphene that is just a single atom thick over ...
... QUINCY, Mass., March 2, 2011 Myriant Technologies, ... of renewable bio-based chemicals, announces the addition of ... effective immediately.  Mr. Ferguson, 56, is the former ... global chemical company engaged in the manufacture and ...
... N.C., March 2, 2011 Cempra Pharmaceuticals Inc. today ... executive officer, will present at the Cowen and Company ... March 7, 2011, at The Boston Marriott Copley Place ... the company,s two leading antibiotic clinical programs, solithromycin for ...
Cached Biology Technology:Penn physicists develop scalable method for making graphene 2Penn physicists develop scalable method for making graphene 3Myriant Technologies, Inc. Announces J. Brian Ferguson to Join Advisory Board 2
... The Jouan MSC series of Class ... working conditions and certification to the ... regulation ensures that the cabinets cannot ... conditions. Natural lighting, low noise and ...
... Fluoroskan Ascent is a ... flexibility for all kinds of ... research and for clinical applications. ... biology are all important application ...
... with class-leading features, the 1400 Series will maximize your ... and consistent every time you use it. ... power consumption by as much as 50% from competitive ... of the cabinet. Multiply this savings by the ...
... for paramagnetic bead precipitation from standard 96-well ... with no additional accessories. The stand has ... SBS 96-well microplate footprint. The use of ... and fast (as little as 30 seconds) ...
Biology Products: