Navigation Links
HIV exploits competition among T-cells

A new HIV study shows how competition among the human immune system's T cells allows the virus to escape destruction and eventually develop into full-blown AIDS. The study, which employs a computer model of simultaneous virus and immune system evolution, also suggests a new strategy for vaccinating against the virus ?a strategy that the computer simulations suggest may prevent the final onset of AIDS.

The research, which is slated for publication in Physical Review Letters, is available online at http://arxiv.org/abs/q-bio.PE/0610018.

"Competition among T cells exerts a small influence for most diseases, but it's fatal for HIV," said study co-author Michael Deem, Rice University's John W. Cox Professor in Biochemical and Genetic Engineering and professor of physics and astronomy.

The new computer model, created by Deem and Guanyu Wang, now an assistant professor of physics at George Washington University, is the first to accurately reproduce all three stages of HIV infection. The first is marked by an initial spike in virus production that's immediately followed by dramatic drop as the immune system recognizes the threat, mounts a defense and destroys most of the invading viruses. The second phase is a long period of clinical latency that can last up to 10 years. In this phase, a small amount of virus mutates fast enough to escape initial detection and continues to mutate over time. The third phase, AIDS, occurs when the virus has changed so much that the body's T cells are no longer effective at keeping it in check.

Deem and Wang's computer model accurately describes all three phases of HIV infection by incorporating a key component: competition among T cells. The model includes two forms of competition. The first form leads to a phenomenon known as deceptive imprinting, or original antigenic sin. Original antigenic sin is the tendency for memory immune cells produced in response
'"/>

Source:Rice University


Page: 1 2 3

Related biology news :

1. Neandertal femur suggests competition with hyenas and a shift in landscape use
2. Birth rate, competition are major players in hominid extinctions
3. Variation in womens X chromosomes may explain differences among individuals, between sexes
4. Disease diagnosis, biodefense among UH chemical research projects
5. HIV drug resistance increasing in UK and among highest in the world
6. Why we give: New study finds evidence of generosity among our early human ancestors
7. Alcoholism, smoking and genetics among Plains American Indians
8. Genetic and environmental influences on alcohol consumption among rhesus monkeys
9. Skin disease common among Hispanic farmworkers in North Carolina, research shows
10. Cell barrier shows why bird flu not so easily spread among humans
11. Higher risk for cervical cancer seen among women infected with multiple HPV types
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: HIV exploits competition among cells

(Date:8/19/2014)... new study of 9- and 10-year-olds finds that those ... compact white-matter tracts in the brain than their peers ... of axons that carry nerve signals from one brain ... with faster and more efficient nerve activity. , ... Frontiers in Human Neuroscience. , "Previous studies suggest ...
(Date:8/18/2014)... ,Trustonic TEE technology ... devices  Trustonic, the leading provider of ... Fingerprint Cards AB (FPC) today announced a collaboration ... biometric authentication on connected devices. The ... FPC1021 and FPC1150) and sensor driver software that ...
(Date:8/18/2014)... The University of Waterloo has unveiled a new satellite ... all over the world gain new insight into the ... between the Canadian Space Agency (CSA), MacDonald, Dettwiler and ... program, and the Canadian Cryospheric Information Network (CCIN) at ... the academic world and the public. , Using ...
Breaking Biology News(10 mins):Physically fit kids have beefier brain white matter than their less-fit peers 2Physically fit kids have beefier brain white matter than their less-fit peers 3Trustonic and Fingerprint Cards Collaborate to Bring Secure Biometrics to Connected Devices 2Trustonic and Fingerprint Cards Collaborate to Bring Secure Biometrics to Connected Devices 3Trustonic and Fingerprint Cards Collaborate to Bring Secure Biometrics to Connected Devices 4Waterloo makes public most complete Antarctic map for climate research 2
... mushrooms rank with carrots, green beans, red peppers and ... researchers say. , Dr. N. Joy Dubost, who recently ... measured the activity of two antioxidants, polyphenols and ergothioneine, ... instrumentation, as part of her dissertation research. She found ...
... could involve a feedback loop that lets the body check ... feedback loops are essential and they abound in biology, they ... the liver to detect if it is injured, ascertain if ... to regenerate itself. When such loops derail, cancer and other ...
... the closest freshwater pond, you'd hesitate before dipping a ... oddly furry, pear-shaped organism gliding along--and gobbling up everything ... a big name-- Tetrahymena thermophila --and a big fan ... into how cells work. , Scientists have now sequenced, ...
Cached Biology News:Mushrooms as good an antioxidant source as more colorful veggies 2Study finds how organs monitor themselves during early development 2Study finds how organs monitor themselves during early development 3Study finds how organs monitor themselves during early development 4What's shaped like a pear and has 2 genomes? Check the pond 2What's shaped like a pear and has 2 genomes? Check the pond 3
(Date:8/18/2014)... Canada (PRWEB) August 18, 2014 ... of opportunity for the clinical research industry. Clinicaltrial.gov ... trials due to its aging population; a high ... chronic diseases; a densely populated pool of patients ... , Notwithstanding these positive points, China also presents ...
(Date:8/16/2014)... August 16, 2014 Firms in ... provide guidance and advisory services to businesses, government ... issues. Industry services are highly diverse as operators ... services range from geological and geophysical consulting services ... over the past five years, the recovery of ...
(Date:8/16/2014)... to make atomic-force microscope probes 20 times more sensitive ... weight of an individual virus. , The technique, developed ... on using laser beams to cool a nanowire probe ... sensitivity achieved after cooling is accurate enough for us ... is 100 billion times lighter than a mosquito," said ...
(Date:8/15/2014)... FOREST, Ill. , Aug. 15, 2014   ... world,s leading provider of injectable drugs and infusion technologies, ... Morgan Stanley Global Healthcare Conference on Tuesday, Sept. 9, ... The presentation is scheduled to begin at 11:45 ... will be available to all interested parties through a ...
Breaking Biology Technology:China – Land of Opportunities & Challenges for the Clinical Research Industry, New Webinar Hosted by Xtalks 2Scientific and Economic Consulting in Canada Industry Market Research Report Now Available from IBISWorld 2Scientific and Economic Consulting in Canada Industry Market Research Report Now Available from IBISWorld 3Laser makes microscopes way cooler 2
... Crosse, Wis. -- Firstlogic Inc. , a ... Corp. approved technology from Firstlogics Information Quality ... ,Oracle Warehouse Builder is a business intelligence integration ... allows users to design their business intelligence application ...
... Madison, Wis Promega Corporation and ... sub-license agreement in which Chemicon may use and ... , ,Under the agreement, Chemicon, California-based division ... use the technology to develop and sell ddRNAi-based ...
... Third Wave Technologies Inc. announced Tuesday that ... successfully extended to chromosomal analysis, opening a new ... with this important extension of the Invader technology, ... Invader analyte-specific reagents (ASRs) for prenatal chromosomal analysis ...
Cached Biology Technology:
... Immunogen: synthetic peptide corresponding to the third ... dopamine receptor, conjugated to KLH. The immunizing ... and mouse gene. Physical form: Solution ... 0.01% sodium azide. Titertest method: IHC ...
Canine Chondrocytes (CnC) (500,000 cells)...
... Fluorescein 6-Fam, Hex, Tet Cy3, ... Fluorescein Tamra Black Hole Quenchers Molecular ... Tet Tamra, Joe 3 Dabcyl ... New York Double labelled probes are purified ...
... Varioskan is a high performance spectral ... and incubator. With the advanced SkanIt ... reliability for drug discovery assay development. ... fluorescence intensity, time-resolved fluorescence and photometric ...
Biology Products: