Navigation Links
HIV dementia alarmingly high in Africa

An international study led by Johns Hopkins suggests that the rate of HIV-associated dementia is so high in sub-Saharan Africa that HIV dementia along with Alzheimer’s disease and dementia from strokes may be among the most common forms of dementia in the world.

In the first study of HIV dementia on the African continent using rigorous neurological and neuropsychological tests, 31 percent of a small but presumably representative group of HIV-positive patients in Uganda were found to have HIV dementia, according to Ned Sacktor, M.D., a Johns Hopkins neurologist and senior author of a multi-institutional study that will be published Jan. 29 in Neurology.

HIV dementia is defined as memory, learning, behavioral and motor disabilities that interfere with normal daily life and in extreme cases lead to total disability and a bedridden state. Unlike Alzheimer’s- and stroke-induced dementia, HIV dementia is treatable and potentially reversible with the same antiretroviral medication that is used to treat the infection. Treatment can even restore completely normal cognitive function to some of those affected.

The study looked at 178 subjects in Kampala, Uganda, from September 2003 to January 2004. Seventy-eight were HIV-positive patients recruited from the Infectious Disease Clinic in Mulago Hospital, Makerere University, and 100 were HIV-negative individuals recruited from the AIDs Information Center who were used to obtain normative data for the cognitive tests.

In diagnosing HIV dementia, researchers looked at medical history and the results of a series of comprehensive neurological and neuropsychological tests and functional assessments.

"Clearly, large-scale testing would have to be conducted before we know the global reach of HIV dementia, but this study sends a clear message that it exists in high proportions in sub-Saharan Africa and is an under-recognized condition that needs to be studied and treated," Sacktor says. < /p>

Of the estimated 40 million adults and children worldwide who are living with HIV infection, an estimated 27 million live in sub-Saharan Africa, according to Sacktor.

"If the rate we saw in our study translates across sub-Saharan Africa, we’re looking at more than 8,000,000 people in this region with HIV dementia," says Sacktor.

Sacktor says an extremely high rate of HIV dementia in Africa and other poor regions of the world adds enormously to the social and economic burden of their populations and governments. Dementia not only disrupts jobs and adds to the cost of care, but also interferes with a patient’s ability to adhere to a regular course of antiretroviral medication, thus increasing the risk of drug resistance. People with dementia also are less likely to practice safe sex.

Before antiretroviral medications were available in the United States, the U.S. rate of HIV dementia was similar to what was discovered in this study in Uganda, says Sacktor. Unfortunately, he says, only 20 percent of people infected with HIV in the world are getting treatment.

"We hope studies like these will shed additional light on the devastating problem of HIV in resource-limited countries like Uganda and encourage more programs that bring much-needed medication to these poor regions of the world," Sacktor says.

Sacktor says there’s little accurate data about HIV dementia patients in other parts of the world --- current estimates of the number of HIV-positive patients who have dementia range from 9 percent to 54 percent.
'"/>

Source:Johns Hopkins Medical Institutions


Related biology news :

1. Scavenger cells could be key to treating HIV-related dementia
2. Fruit fly reveals a potential connection between dementia and cancer
3. Hopkins study suggests commercially available antibiotic may help fight dementia in HIV patients
4. In-home sensors spot dementia signs in elderly
5. Viral genetic differences are possible key to HIV dementia
6. High estrogen levels associated with dementia in older men
7. Researchers find cause of frontotemporal dementia
8. Canadian study shows bilingualism has protective effect in delaying onset of dementia by four years
9. Vasectomy may put men at risk for type of dementia
10. Gene tests and brain imaging reveal early dementia
11. Scientists discuss improved biopesticides for locust control in West Africa

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/7/2017)... 7, 2017 Zimmer Biomet Holdings, Inc. (NYSE ... will present at the LEERINK Partners 6th Annual Global ... on Wednesday, February 15, 2017 at 10 a.m. Eastern ... presentation can be accessed at http://wsw.com/webcast/leerink28/zbh .  The ... via Zimmer Biomet,s Investor Relations website at http://investor.zimmerbiomet.com ...
(Date:2/3/2017)... WASHINGTON , Feb. 3, 2017 A ... Identity Strategy Partners, LLP (IdSP) . Designed to ... in the complex identity market, founding partners Mark ... nearly 35 combined years just in identity expertise that ... tank and non-profit leadership. The Crego-Kephart combined expertise has ...
(Date:2/1/2017)... , February 1, 2017 IDTechEx Research, ... on emerging technology, announces the availability of a new report, ... Continue Reading ... ... industrial and collaborative robots. Source: IDTechEx Report "Sensors for Robotics: Technologies, ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... SAN FRANCISCO , Feb. 23, 2017 /PRNewswire/ ... and Beyond Type 1, a not-for-profit advocacy and education ... announced a grant from Beyond Type 1 to support ... 1 and other insulin-requiring diabetes.  For ... stem cell-derived cell replacement therapies with a focus on ...
(Date:2/22/2017)... CA (PRWEB) , ... February 22, 2017 , ... ... announced that is has acquired Kendall Research Systems, LLC (KRS) clinical ... (MIT) that develops neural interface technology for research and clinical applications. The terms ...
(Date:2/22/2017)... Feb. 22, 2017 Scientists propose in ... organ damage in Gaucher and maybe other lysosomal storage ... lower costs than current therapies. An international ... Center , which also included investigators from the University ... their data Feb. 22. The study was conducted in ...
(Date:2/22/2017)... , ... February 22, 2017 , ... ... tech innovators, engineers, and scientists from around the world, is pleased to announce ... February 22 and 23, 2017. This premier, online-only conference focused on the development ...
Breaking Biology Technology: