Navigation Links
HIV/AIDS linked to extensively drug resistant TB

A highly drug-resistant form of tuberculosis (TB) has been linked to HIV/AIDS in a study conducted in rural South Africa by researchers at Yale School of Medicine.

Published in the October 26 issue of The Lancet, the study is the result of a five-year collaboration between a Yale and South African team of researchers who aim to integrate HIV and TB care and treatment.

TB is the most common cause of death and illness in those with HIV infection in sub-Saharan Africa. HIV greatly increases the risk of active TB disease and about 80 percent of patients with active TB in the province of KwaZulu Natal, South Africa, are co-infected with HIV. Death rates of up to 40 percent per year have been reported in patients with both HIV and TB.

Led by senior author Gerald Friedland, M.D., director of the AIDS Program at Yale and Professor in the Departments of Medicine and Epidemiology and Public Health, the study measured the prevalence of multi-drug resistant (MDR) tuberculosis and extensively drug-resistant (XDR) tuberculosis in a hospital in KwaZulu Natal. Between January 2005 and March 2006, sputum samples from 1,539 patients were screened. MDR TB was found in 221 patients and of those, 53 had XDR TB. Those patients with XDR who were tested for HIV were found to be co-infected. All but one of the 53 patients with both XDR TB and HIV died, with an average survival of 16 days.

"This is an issue of grave worldwide importance," said Friedland. "MDR and XDR carry the danger of blunting or reversing the success of TB programs and the roll-out of anti-retroviral therapies for HIV where they are desperately needed in resource limited settings. Urgent intervention is necessary, especially now that we know that MDR tuberculosis is far more prevalent than previously thought and that XDR tuberculosis has been transmitted to HIV co-infected patients and associated with high mortality."

Future studies will involve defining the extent and conseq uences of the problem in greater detail, Friedland said, with operational research focused on quickly determining what kind of infection control practices can practically and feasibly be instituted to reduce the transmission of this lethal form of tuberculosis to others.

Friedland said there is a desperate need for new diagnostic tests and treatment for TB. "It is still being diagnosed the same way it was in 1882," he said. "Modern technology for diagnosis and new treatment needs to be developed urgently. The last approved TB drug was 40 years ago."
'"/>

Source:Yale University


Related biology news :

1. New therapy for HIV/AIDS eliminates needles and excessive toxicity
2. South Africa still debating how to tackle HIV/AIDS when 5 million are infected
3. AIDS expert says global strategy needed to combat feminization of HIV/AIDS
4. Progress on HIV/AIDS significant but insufficient
5. HIV/AIDS rates in Tijuana, Mexico increasing at alarming rate
6. International HIV/AIDS trial finds continuous antiretroviral therapy superior to episodic therapy
7. Study defines effective microbicide design for HIV/AIDS prevention
8. Rhesus monkeys in Nepal may provide new alternative for HIV/AIDS research
9. Cornell researcher helping develop quick, cheap HIV/AIDS test
10. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
11. Low level of extinction during ice age linked to adaptability

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... -- Research and Markets has announced the addition of ... Industry Forecast to 2025" report to their offering. ... The Global Vehicle Anti-Theft ... 8.8% over the next decade to reach approximately $14.21 billion by ... and forecasts for all the given segments on global as well ...
(Date:3/20/2017)... , March 20, 2017 At this year,s CeBIT ... -based biometrics manufacturer DERMALOG. The Chancellor came to the DERMALOG stand together ... is this year,s CeBIT partner country. At the largest German biometrics company ... use: fingerprint, face and iris recognition as well as DERMALOGĀ“s multi-biometrics system.   ... ...
(Date:3/9/2017)... Australia , March 9, 2017 ... the prestigious World Lung Imaging Workshop at the University ... , was invited to deliver the latest data to ... globally recognised event brings together leaders at the forefront ... developments in lung imaging. "The quality ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... -- Kineta, Inc., a biotechnology company focused on ... today announced the discovery and characterization of several ... interferon response factor 3 (IRF3) via RIG-I like ... in a murine colon carcinoma mouse model.  Furthermore, ... regression to initial drug treatment were resistant to ...
(Date:3/23/2017)... 23, 2017  Agriculture technology company Cool Planet has ... note conversion to commercialize its Cool Terra and Cool ... developing products that are simultaneously profitable as well as ... last 18 months. This latest round of funding was ... The company,s primary product, Cool Terra, ...
(Date:3/22/2017)... Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN), today announced a ... Biobank and GSK to generate genetic sequence data from the ... will enable researchers to gain valuable insights to support advances ... of serious and life threatening diseases. ... Genetic evidence has revolutionized ...
(Date:3/22/2017)... March 22, 2017  UBM and the Massachusetts ... their extended partnership and the third annual Massachusetts Medtech ... the 21 st Annual MassMEDIC Conference held ... May 3-4, 2017. MassMEDIC will ... (ADVAMED) President and CEO, Scott Whitaker , ...
Breaking Biology Technology: