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HIV-1 spread through six transmission lines in the UK

S in 1982. Despite a recent increase in heterosexually acquired infections within the UK , predominantly originating in sub- S aharan A frica , one of the most prevalent clades (subtypes) of virus within the country remains subtype B, which is mainly transmitted through sex between men. Very little is known about how subtype B successfully invaded the British population, and more importantly, how the virus has subsequently spread and evolved.

However, given that the first UK cases of AIDS reported in 1982 were probably infected within a window of 10 years prior to that time, the currently circulating strains may not represent the first HIV-1 lineages within the UK . If earlier strains existed they may have been unsuccessful in sustaining transmission to the present, although the absence of older strains could also reflect a sampling bias in this study.


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Source:UCL


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