Navigation Links
HIV-1 kills immune cells in the gut that may never bounce back

People with HIV have been living longer, healthier lives since the development of highly active antiretroviral therapy (or HAART) in 1995. In fact, most patients on the drug regimen do so well that, according to blood tests, their immune cells appear to return to pre-HIV levels. But two new studies from Rockefeller University and the Aaron Diamond AIDS Research Center (ADARC) show that the immune cells in other body tissues may never rebound, suggesting the need for additional ways to monitor immune system health, and the need for hypervigilance as HIV-positive patients live into their forties, fifties, sixties and beyond. The findings are reported in today's issue of PLoS Medicine and online in the Journal of Virology.

Prior research had shown that, just two to four weeks after contracting HIV-1, the lymphoid tissue layer in the mucous membrane of a patient's gastrointestinal (GI) tract can lose up to 60 percent of its CD4 memory T cells -- immune cells responsible for recognizing invaders and priming other cells for attack. Intrigued, Martin Markowitz, an Aaron Diamond Professor at Rockefeller University and a staff scientist at ADARC, wanted to know whether this loss was reversible, and whether giving patients HAART during the early infection period helped restore these cells to the GI lining the way it restored them to the blood itself.

In a paper published today in PLoS Medicine, Markowitz, Rockefeller researcher and clinical scholar Saurabh Mehandru, and their colleagues report on a trial of 40 HIV-1 positive patients who began treatment with HAART shortly after contracting the virus -- during the acute early infection phase -- and who they followed from one to seven years. The researchers found that although the blood population of CD4 T cells rebounded to normal levels, a subset of the GI tract population remained depleted in 70 percent of their subjects.

"If we sample the blood, it only has two percent of the total volume of the
'"/>

Source:Rockefeller University


Page: 1 2 3

Related biology news :

1. Research advances quest for HIV-1 vaccine
2. HIV-1 spread through six transmission lines in the UK
3. Ancient immune defense mechanism is no match for HIV-1
4. UAB researchers confirm HIV-1 originated in wild chimpanzees
5. HIV-1s high virulence might be an accident of evolution
6. Human testis harbors HIV-1 in resident immune cells
7. Researchers discover new details about HIV-1 entry and infection
8. Study: Harmless virus kills some cancers
9. VCU study shows hormone-like molecule kills cells that cause inflammation in allergic disease
10. Scientists develop nanotech-laser treatment that kills cancer cells without harming healthy tissue
11. Restoring silenced suppressor gene kills lung-cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: HIV kills immune cells the gut that may never bounce back

(Date:11/21/2014)... REDMOND, Wash. , Nov. 20, 2014 ... access for the Internet of Things (IoT), today announced ... position of chief operating officer. Previously a strategic advisor ... marketing, finance, and operations. Mr. Traynor is based out ... . He reports to Chris Muench , ...
(Date:11/18/2014)... , Nov. 17, 2014   ... EMC collaborate to develop The Partners Data Lake, ... The Partners Data Lake will allow researcher and ... diagnostics, treatment and the lives of patients ... and clinical activities across the Partners system, breaking ...
(Date:11/15/2014)... 13, 2014  While we may still be a few ... in "Star Trek" to gain instant access to all that ... with smartphones and tablets for monitoring and measuring our health ... This may seem a tad Orwellian to some, but a ... of these technological opportunities into their healthcare regime. ...
Breaking Biology News(10 mins):C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4
... missing flu virus. When the flu isnt making people sick, ... Earth, it reappears in the appropriate season and starts its ... it hibernate, lying dormant in a few people and preparing ... Northern hemisphere to the Southern hemisphere and back, following the ...
... Researchers have discovered the secrets to enhancing youth ... 3-year study entitled Greener Voices proves that children ... responsibility for decisionmaking and planning. Childrens gardens ... are popping up in schools, communities, public venues, ...
... in Spanish . Breaking up the dosage ... of wheat and limits its negative effects on the environment. ... of the Basque Country (UPV-EHU) researcher, Teresa Fuentes Mendizbal, presented ... Wheat yields have increased over the decades, more concretely during ...
Cached Biology News:Tracking influenza's every movement 2Children's gardens mushrooming 2Dosage of fertilizer helps to enhance quality of wheat 2Dosage of fertilizer helps to enhance quality of wheat 3
(Date:12/17/2014)... Dec. 17, 2014 Tigercat Pharma, Inc. ... study evaluating the investigational oral NK-1 receptor antagonist ... severe, chronic itch who are unresponsive or inadequately ... topical steroids and antihistamines. The ... Analog Scale (VAS) itch score from baseline, comparing ...
(Date:12/15/2014)... YORK , Dec. 15, 2014  GlassesOff Inc. ... Yuval Bar-Gil as an independent director of the ... founder of AeroScout and served as its CEO until ... in 2012, a $240 million transaction. Recognized as the ... Mr. Bar-Gil,s leadership, AeroScout provided Wi-Fi -based RFID solutions ...
(Date:12/13/2014)... Clarassance, a privately held clinical-stage biotechnology company based ... Therapeutics , Inc. The new name is derived from ... in the lungs similar to branches on a tree), ... therapeutics for the treatment of respiratory diseases. , ... to mark the company's escalation into the clinical phase ...
(Date:12/13/2014)... December 13, 2014 QuickSTAT is making ... and Cold Chain capabilities, and is delighted to announce ... France, to serve Life Science clients in the region. ... a controlled-ambient warehouse, will provide 24/7 transportation and logistics ... investigational drugs, patient-clinical specimens, API, following IATA rules and ...
Breaking Biology Technology:Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2Quick Opens Office in France to Serve Life Science Community In France and Neighboring French-Speaking Countries 2
... America, Inc.  (OTC Bulletin Board: CBAI ) announced ... www.bancovida.com ) to offer umbilical cord blood collection services in ... will allow BancoVida and Cord Blood America to educate prospective ... of storing their baby,s umbilical cord blood.  The stem cells ...
... 26, 2011 Infrared Systems International (OTCBB: IFRS) announces ... strategies for continued success. Most recently, the ... its subsidiary, Infrared Applications, Inc. (IAI).  The distribution marks ... from one engaged in the aerospace industry to one ...
... Shire plc (LSE: SHP, NASDAQ: SHPGY ... U.S. Food and Drug Administration (FDA) has granted marketing approval ... attacks of hereditary angioedema (HAE) in adults 18 years of ... challenges gaining rapid access to acute treatment such as the ...
Cached Biology Technology:Cord Blood America Enters Agreement With BancoVida, a Cord Blood Collection Company in San Juan, Puerto Rico 2Infrared Systems International Reflects on Past and Looks Forward to the Future 2Infrared Systems International Reflects on Past and Looks Forward to the Future 3FDA Approves Shire's FIRAZYR® (icatibant injection) for Acute Attacks of Hereditary Angioedema (HAE) 2FDA Approves Shire's FIRAZYR® (icatibant injection) for Acute Attacks of Hereditary Angioedema (HAE) 3FDA Approves Shire's FIRAZYR® (icatibant injection) for Acute Attacks of Hereditary Angioedema (HAE) 4FDA Approves Shire's FIRAZYR® (icatibant injection) for Acute Attacks of Hereditary Angioedema (HAE) 5FDA Approves Shire's FIRAZYR® (icatibant injection) for Acute Attacks of Hereditary Angioedema (HAE) 6
Human TFPI Affinity Purified Polyclonal Ab Protein Family: Coagulation, Inflammation, Serine Protease Regulators...
TMB Slow Kinetic One Component HRP Microwell Substrate, 1 L...
Eppendorf tube holder, for Tube rack 175 x 12 mm, 100. Category: Chromatography Systems & Accessories, Systems....
Pooled normal sreum with 0.1% sodium azide as preservative...
Biology Products: