Navigation Links
H5N1 vaccine could be basis for life-saving stockpile

re antibody protection than a single dose. Immunologically naïve individuals are those whose immune systems have not been stimulated to respond to a particular antigen.

The St. Jude study was the first one to show cross-reactive immunity against current H5N1 variants in ferrets, according to Robert Webster, Ph.D., a member of the Infectious Diseases department and holder of the Rose Marie Thomas Chair at St. Jude. Webster is an internationally renowned expert on avian influenza viruses and is senior author of the report in JID.

Cross-reactive immunity is the protection that a virus vaccine confers against not only the same virus, but also against variants of the original virus. "Such cross-protection would allow the use of a stockpiled vaccine until a vaccine against the specific variant causing the outbreak is developed," Webster said. "So our success with ferrets is extremely promising news."

Using reverse genetics, the team mixed genes from a safe, laboratory bird flu virus with a gene for the hemagglutinin (HA) protein from the H5N1 virus isolated in Hong Kong. The virus uses the HA proteins on its surface to infect cells in the respiratory tract. The resulting vaccine had the outside appearance of a dangerous virus that would stimulate the immune system, but the inside genes of a harmless variety of virus that could not cause disease. The St. Jude team was the first to use reverse genetics to make a vaccine against H5N1 that moved out of the laboratory and into clinical trials: http://www.stjude.org/media/0,2561,453_5484_4638,00.html.


'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2

Related biology news :

1. Research advances quest for HIV-1 vaccine
2. A much-needed shot in the arm for HIV vaccine development
3. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
4. Gene vaccine for Alzheimers disease shows promising results
5. Influenza vaccine uses insect cells to speed development
6. Norovirus, AIDS vaccine and Hepatitis Virus
7. HIV vaccine trial breaks ground for future research
8. Live vaccines more effective against horse herpes virus
9. NIAID begins clinical trial of West Nile virus vaccine
10. Designing vaccines by computer
11. Wake Forest scientists find new combination vaccine effective against plague
Post Your Comments:
(Date:12/15/2009)... The mouse is a standard laboratory model organism, ... conventional techniques to analyze blood and blood-forming tissues ... of compact and easy-to-use laboratory resources from Cold ... Mouse Hematology features step-by-step protocols for ... blood, bone marrow, and other hematopoietic tissues in ...
(Date:12/14/2009)... have identified a novel antifreeze molecule in a freeze-tolerant ... degrees Fahrenheit. Unlike all previously described biological antifreezes that ... or no protein. It is composed of a sugar ... places within the cells of organisms. , "The ... molecule is a whole new kind of antifreeze that ...
(Date:12/14/2009)... comprehensive study to date of the proteins in a ... important clues to how similar regeneration could be induced ... Science at Indiana University-Purdue University Indianapolis and colleagues investigated ... axolotls, a type of salamander that has the unique ... amputation, with the hope that this knowledge will contribute ...
Breaking Biology News(10 mins):New source of classical techniques for blood-based studies in the laboratory mouse 2Scientists isolate new antifreeze molecule in Alaska beetle 2IUPUI researchers tackle protein mechanisms behind limb regeneration 2BioConference Live Kicks off Three Day Online Event for Life Science and Biotech Communities Today at 9 3A00 AM Eastern 61505 1BioConference Live Kicks off Three Day Online Event for Life Science and Biotech Communities Today at 9 3A00 AM Eastern 61505 2BioConference Live Kicks off Three Day Online Event for Life Science and Biotech Communities Today at 9 3A00 AM Eastern 61505 3NYC Chiropractor Adds New Therapy for Chronic Back Neck and Joint Pain to Downtown Practice 61503 1NYC Chiropractor Adds New Therapy for Chronic Back Neck and Joint Pain to Downtown Practice 61503 2Obesity Rates Will Continue to Increase Drive Health Care Costs in New Jersey in Next Decade According to New Study 61501 1Obesity Rates Will Continue to Increase Drive Health Care Costs in New Jersey in Next Decade According to New Study 61501 2
... of New South Wales (UNSW) research has highlighted a link ... pregnancy. The work in animals proves that overweight expectant mothers ... who are at greater risk of diabetes and lipid metabolic ... 30 percent of women who become pregnant are overweight. , ...
... Oct. 21 Evolved Machines, Inc. has,been ... new Defense Advanced Research,Projects Agency (DARPA) program ... neural pattern recognition. The $5.1 million,dollar contract ... corporations to,develop a highly versatile and sensitive ...
... non-animal testing deadlines loom for manufacturers of chemicals for ... meeting in Philadelphia will bring together scientists, cosmetics formulators, ... 7th Amendment of the Cosmetics Directive, a series of ... REACH, a massive undertaking to identify potential hazards from ...
Other Biology News:Overweight mums have chubby bubs 2Spotlight on cosmetic ingredients conference 2
(Date:12/15/2009)... and LONDON, Dec. 15 ... Thomson Pharma ® has become the first drug ... protocol and outcome information. This highly anticipated new ... customers this month. ,, Thomson ... intelligence from registries, publications, press releases, conferences, and ...
(Date:12/15/2009)... The Prinz Law Office has announced the launch of ... businesses secure legal services in the current economic climate. ... them the opportunity to finance legal services over a ... requiring any equity in their start-up companies. The ... for fixed montly payment arrangements over 6 to 12 ...
(Date:12/14/2009)... Dec. 14 Vermillion, Inc. (Pink ... announced William C. Wallen, Ph.D. Chief Scientific ... for IDEXX Laboratories, will be joining its ... bankruptcy plan. ,, "Bill brings more ... in diagnostics and biotechnology," said Gail Page, ...
(Date:12/14/2009)... Rep. Patrick Kennedy Joins with State Biotech ... Leadership in Research and Development while Boosting ... Industry ,, PROVIDENCE, R.I., Dec. 14 ... prominent leaders in research, medicine and biotechnology ... Facility to discuss the importance of medical ...
Breaking Biology Technology:Thomson Reuters is First to Offer Fully Integrated Pipeline and Clinical Trials 2The Prinz Law Office Launches Innovative New Programs to Aid Cash-Strapped Entrepreneurs and Businesses 2Vermillion Announces Appointment of William C. Wallen, Ph.D. to Board of Directors 2Vermillion Announces Appointment of William C. Wallen, Ph.D. to Board of Directors 3Vermillion Announces Appointment of William C. Wallen, Ph.D. to Board of Directors 4Former Congressman Dick Gephardt Brings National Spotlight to Rhode Island with 'Best and Brightest Forum on Medical Innovation' 2Former Congressman Dick Gephardt Brings National Spotlight to Rhode Island with 'Best and Brightest Forum on Medical Innovation' 3Former Congressman Dick Gephardt Brings National Spotlight to Rhode Island with 'Best and Brightest Forum on Medical Innovation' 4
... LAVAL, QC, Sept. 15 /PRNewswire-FirstCall/ - Neptune ... reported today,that its distributor Schiff Nutrition International ... Oil (NKO(R)) in Walgreens,which represents the largest ... over 6,400 drug stores nationwide. Schiff(R) MegaRed(TM) ...
... - Oncentra(R) RT Viewer* Officially to Launch ... ASTRO 2008, Boston, USA, September,21-24, Nucletron, a ... release of Oncentra RT Viewer. This unique innovation,in ... review,radiotherapy plans that are generated with a wide ...
... Conference, MONTREAL, Sept. 12 /PRNewswire-FirstCall/ - ProMetic ... Pierre Laurin, President,and Chief Executive Officer, will present ... September 16, 2008 at 16:00 (PDT). This event,will ... in San Francisco., More information about the ...
Other Biology Technology:Neptune Krill Oil, NKO(R), enters WALGREENS, the largest U.S. retail pharmacy chain, under the brand name Schiff(R) MegaRed(TM) 2Neptune Krill Oil, NKO(R), enters WALGREENS, the largest U.S. retail pharmacy chain, under the brand name Schiff(R) MegaRed(TM) 3Nucletron Announces Market Release of First Commercially Available Software to Review and Share Dicom-Based Treatment Plans for Radiotherapy 2ProMetic to present at Merriman Curhan Ford's Investor Summit 2008 on September 16th 2
Dopamine D2 and D3 receptor, human and possibly mouse. AB1502 detects 40 ng of dopamine receptor peptide by ELISA. AB1502 is not neutralizing....
Rabbit polyclonal to Factor IX ( Abpromise for all tested applications). entrezGeneID: 2158 SwissProtID: P00740...
Adhesion Molecule Antibodies...
Rabbit polyclonal to Glutathione S Transferase alpha ( Abpromise for all tested applications). Antigen: Full length protein: Human Glutathione S Transferase alpha. Entrez GeneID: 2938 Swi...
Biology Products: