Navigation Links
H5N1 avian flu virus vaccine induces immune responses in healthy adults

greater the antibody response produced. Of the 99 people evaluated in the 90-mcg, high-dose group, 54 percent achieved a neutralizing antibody response to the vaccine at serum dilutions of 1:40 or greater, whereas only 22 percent of the 100 people evaluated who received the 15-mcg dose developed a similar response to the vaccine.

Generally, all dosages of the vaccine appeared to be well tolerated:

  • Almost all reported side effects were mild
  • The second dose of vaccine did not cause more local or systemic symptoms than the first
  • Systemic complaints of fever, malaise, muscle aches, headaches and nausea occurred with the same frequency in all dosage groups as in the placebo group
  • Lab tests did not reveal any clinically significant abnormalities

The vaccine, made from an inactivated H5N1 virus isolated in Southeast Asia in 2004, was manufactured by sanofi pasteur, Swiftwater, PA, under contract to NIAID. Because there are no manufacturers licensed in the United States to use adjuvants in inactivated influenza vaccines, NIAID's first step was to test an H5N1 influenza vaccine made in a way that mimics the process used to make conventional flu vaccines. The clinical data collected in this study are now available to support the potential use of this vaccine should it be needed for an emerging pandemic.


'"/>

Source:NIH/National Institute of Allergy and Infectious Diseases


Page: 1 2 3

Related biology news :

1. Bird samples from Mongolia confirmed as H5N1 avian flu
2. WCS says avian flu prevention should focus on farms, markets
3. Less virulent strains of avian influenza can infect humans
4. Drug resistant avian influenza viruses more common in Southeast Asia than North America
5. Volunteers sought for avian flu vaccine study
6. Vaccine provides 100 percent protection against avian flu virus in animal study
7. Medical experts: US unlikely to have enough vaccines to stop avian flu
8. Minor mutations in avian flu virus increase chances of human infection
9. H9N2 avian flu vaccine paired with adjuvant provokes strong human immune response at low doses
10. Pacific Rim researchers to collaborate on distributed bioinformatics analysis of avian flu
11. Map predicting spread of avian flu

Post Your Comments:
(Date:11/23/2009)...ra Romeo Casabona is Director of the Interuniversi...eusto University and the University of the Basque ...urists but also has other experts such as research...nd even specialists in ethics. , The Interuniver... the Universities of Deusto and the Basque Country...
(Date:11/23/2009)...ease is available in German . , Of all glob...late in the atmosphere where it contributes to glo...s and terrestrial ecosystems such as forests, gras...ice" of aquatic and terrestrial ecosystems is cons... of reducing climate change. However, new greenhou...
(Date:11/22/2009)...y inherited gene deletion can increase the likelih...transplantation, an international team of research...e of Nature Genetics . When the gene, called UGT2...t in the recipient,s, transplants have a significa...s graft-versus-host disease, in which immune cells...
Breaking Biology News(10 mins):Research and legislation should go hand in hand, as much as possible 2Intensive land management leaves Europe without carbon sinks 2Gene mismatch influences success of bone marrow transplants 2Gene mismatch influences success of bone marrow transplants 3Gene mismatch influences success of bone marrow transplants 4LCA Congratulates Nominee For Surgeon General 51696 1LCA Congratulates Nominee For Surgeon General 51696 2New RISI Report Analyzes South American Tree Farm and Biomass Energy Investment Opportunities 13027 1New RISI Report Analyzes South American Tree Farm and Biomass Energy Investment Opportunities 13027 2New RISI Report Analyzes South American Tree Farm and Biomass Energy Investment Opportunities 13027 3Warner Chilcott Announces Earnings Release Date and Conference Call For Second Quarter 2009 Financial Results 51693 1
...nce of life in outer space may have a surprisingly... of Houston professor. , Understanding how life e... to where else in the universe one might find life...UH professor of biology and biochemistry. Fox is f...NASA,s Exobiology Program that seeks to understand...
...ts have employed a computer simulation whose resul...NA transcription process. The study, funded by the...e 7 issue of the Proceedings of the National Acade...that chromatin--a chromosome,s substance consistin...dent conformations. Specifically, chains of nucleo...
...hat the brain,s central timekeeper - the biologica...- has two parts that fall out of synchrony during ...kes to fly across the Atlantic. , The finding may ...lers suffer from jet lag, the malaise experienced ...anding could eventually lead to the development of...
Other Biology News:Evolution of life on Earth may hold key to finding life in outer space 2Evolution of life on Earth may hold key to finding life in outer space 3New understanding of jet lag 2New understanding of jet lag 3
(Date:11/20/2009)... , ROCKVILLE, Md., Nov. 20 /PRNewswire-FirstCal...ed that it has priced an underwritten public offer...rice to the public of $3.30 per share. The approx...ng the underwriting discounts and commissions, wil...als of our VLP-based vaccines, internal research a...
(Date:11/20/2009)... , SEATTLE, Nov. 20 ...IC) announced today that the Ninth Circuit Court o... ruled that CTI should be allowed to pursue all of...se back to the District Court for trial. CTI file... third-party reimbursement consultant for CTI,s pr...
(Date:11/20/2009)... METTLER TOLEDO recently announc... webinar, “The Role of Process Analytical Te...ering” on December 1, 2009. , ... The Role of Process Analytical Technology (PAT) ...on December 1, Process Analytical Technology (PAT)...
(Date:11/19/2009)..., COPENHAGEN, Nov. 19 Danish Prin... cellulosic ethanol plant in Kalundborg, Denmark, ...the world,s first and largest 2nd generation ethan...rase enzymes are used in the plant,s innovative pr...vision of Danisco, was the first to market with co...
Breaking Biology Technology:Novavax Prices Public Offering of Common Stock 2Cell Therapeutics Wins Federal Appeal to Pursue $22.8 Million Claim Against The Lash Group 2Process Analytical Technology (PAT) in Green Chemistry and Green Engineering 2DONG Energy and Inbicon Inaugurate One of the World's Largest Demo Plants for 2nd Generation Biofuel 2
...sion this fall entitled, The Happy Marriage of IT ...nology (IT) and biotechnology are happily married,.... So, I talked with John Barni , CEO of TomoThe...titive advantage? TomoTherapy, a biotechnology co...or, is revolutionizing cancer treatment by targeti...
...ocessing Services selected BMC Software ,s MAINV...sponse time of its credit card and credit applicat...rvices provides outsourced credit receivables mana...iserv Credit Processing Services provides clients ...age credit decisions, account acquisition, account...
...any ways to share information. But most of us rely...int. , ,We all use portals of various types. News ...at portals. Some of us use project management, dat...ll these are now available not only as stand alone...s that are available 24/7. , ,The problem is that...
Other Biology Technology:TomoTherapy: A Marriage of IT and Biotech 2E-Mail Collaboration Problems 2E-Mail Collaboration Problems 3E-Mail Collaboration Problems 4
...lyclonal Antibody Production Conjugated peptide...bits ten-week protocol to produce antibodies in 2...-120 ml antiserum) ELISA test until the titer rea...ches target titer Protein G purification Antibod...
3' RACE Adapter Primer from Invitrogen
Normal Goat Serum from Calbiochem
Polyvalent HRP AEC Detection System from Spring Bioscience
Biology Products: