Navigation Links
Growth factor stimulates rapid extension of key motor neurons in brain

A growth factor known to be important for the survival of many types of cells stimulates rapid extension of corticospinal motor neurons ?critical brain cells that connect the cerebral cortex with the spinal cord and that die in motor neuron diseases like amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease). In the November 2006 issue of Nature Neuroscience, two investigators from Massachusetts General Hospital (MGH) and the Harvard Stem Cell Institute describe how insulin-like growth factor 1 (IGF-1) dramatically increases the in vitro growth of corticospinal motor neuron (CSMN) axons ?projections that carry nerve impulses to the spinal motor neurons that connect to muscles ?and that blocking IGF-1 activity reduces that growth in both cultured cells and in living mice.

"Our findings that IGF-1 specifically enhances both the speed and extent of axon outgrowth of corticospinal motor neurons are the first direct evidence of growth factor control over the differentiation of these neurons, " says Jeffrey Macklis MD, DHST, director of the MGH-Harvard Medical School (HMS) Center for Nervous System Repair, the report's senior author. "In addition to providing insight into the development and circuit formation of this critical population of neurons, these results might lead to the future ability to treat motor neuron disorders and spinal cord injuries."

Although their cell bodies are located in the brain, CSMN axons extend down to the neurons they control in the spinal cord ?extending as far as three feet in adult humans. These neurons degenerate in ALS and related disorders, and their damage contributes to loss of motor function in spinal cord injuries. Since they are embedded among hundreds of other types of neurons in the cerebral cortex, it has been difficult to study CSMN, and little has been known about cellular and molecular factors that control their growth and development. In order to study growth factor controls over these cells, Mack
'"/>

Source:Massachusetts General Hospital


Page: 1 2

Related biology news :

1. Growth in the sea comes down to a struggle for iron
2. Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells
3. Growth in biomass could put US on road to energy independence
4. Embryonic Stem Cells Treated With Growth Factor Reverse Hemophilia In Mice: UNC Researchers
5. Missing Receptor Molecule Causes Tumor Growth
6. Growth hormone is made in the brain, report scientists
7. Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons
8. New Research Shows Artificial Light at Night Stimulates Breast Cancer Growth in Laboratory Mice
9. Growth hormone to boost athletic performance risks diabetes
10. Growth hormone is not the anti-aging bullet for healthy adults
11. Cracking the olfactory code in bees
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Growth factor stimulates rapid extension key motor neurons brain

(Date:10/15/2014)... awarded the 44th Rosenstiel Award for Distinguished Work in ... exploring the mechanisms of genomic instability and its implications ... the second alumnus to win the Rosenstiel Award; the ... , Alt is the Charles A. Janeway Professor of ... and an investigator at the Howard Hughes Medical Institute ...
(Date:10/14/2014)... DURHAM, N.C. – Like discriminating thieves, prostate cancer tumors ... in the body. But such avarice may be a ... found a way to kill prostate cancer cells by ... that selectively destroys the diseased cells brimming with the ... which uses two drugs already commercially available for other ...
(Date:10/14/2014)... Ohio (Oct. 14, 2014)—It,s been millions of years since ... a team led by Ohio University scientists is breathing ... model airflow through dinosaur snouts. The research has important ... only breathe but to enhance the sense of smell ... ,nosy, animals," said Ohio University doctoral student Jason Bourke, ...
Breaking Biology News(10 mins):Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2Prostate cancer's penchant for copper may be a fatal flaw 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3
... of the Eastern Illinois Foodbank shared results of a ... domestic hunger-relief organization. The study is completed every four ... effectiveness of emergency food distribution throughout the United States. ... Agricultural and Consumer Economics at the University of Illinois, ...
... homosexuality doesn,t make complete sense from an evolutionary point ... but because homosexual men are much less likely to ... this trait have been extinguished long ago? What value ... for eons even without any discernible reproductive advantage? ...
... at Washington University in St. Louis sheds light on one ... land by plants 480 million years ago. No would-be ... to deal with dehydration, a major threat for organisms accustomed ... land plants managed to avoid drying out might be provided ...
Cached Biology News:U of I faculty assist in evaluating US food security programs 2Study reveals potential evolutionary role for same-sex attraction 2Study reveals potential evolutionary role for same-sex attraction 3Moss helps chart the conquest of land by plants 2Moss helps chart the conquest of land by plants 3Moss helps chart the conquest of land by plants 4
(Date:10/19/2014)... (PRWEB) October 20, 2014 ... Industry Meeting (ABIM). ABIM will take ... More information about ABIM 2014 is now ... , Delegates representing companies and organizations from ... and obtain information on the latest products ...
(Date:10/19/2014)... The report "Chocolate, Cocoa Beans, Lecithin, Sugar and ... and Forecast (2011 - 2016)," analyzes the chocolate ... the major market drivers, restraints, and opportunities for the ... The global chocolate market is expected to grow from ... an estimated CAGR of 2.7% from 2011 to 2016. ...
(Date:10/18/2014)... The Asia-Pacific Bio-based Advanced Phase ... bio-based advanced phase change material market in Asia-Pacific ... through the TOC of the Asia-Pacific Bio-based Advanced ... idea of the in-depth analysis provided. This also ... Asia-Pacific bio-based advanced phase change material market, and ...
(Date:10/18/2014)... (PRWEB) October 18, 2014 The Asian Electronic ... market in Asian with analysis and forecast of revenue. The ... to grow to $2,328.0 million by 2018, at a CAGR ... TOC of the Asian Electronic Medical Record (EMR) market, to ... provides a glimpse of the segmentation of the market in ...
Breaking Biology Technology:Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 4The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 2The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 3The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 4The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 5
... 29, 2011 Texas Children,s Hospital in Houston announced today ... States to implant an artificial heart into the chest of ... life. The history-making patient underwent a rare 15-hour operation on ... He is one of three congenital heart patients in the ...
... 2011 UCB and Harvard University will officially launch ... to take place in Boston in the presence of ... The Alliance creates a unique drug discovery bridge between ... that holds potential for the development of new therapeutic ...
... (Nasdaq: VRNM ), a leading industrial biotechnology company ... announced the signing of a lease agreement for new office ... Diego, CA.  The lease is targeted to commence in the ... facility and the expiration of Verenium,s current sublease, which was ...
Cached Biology Technology:Texas Children's Hospital is First Pediatric Hospital in the Nation to Implant Artificial Heart 2Texas Children's Hospital is First Pediatric Hospital in the Nation to Implant Artificial Heart 3Texas Children's Hospital is First Pediatric Hospital in the Nation to Implant Artificial Heart 4Texas Children's Hospital is First Pediatric Hospital in the Nation to Implant Artificial Heart 5UCB to Launch Research Alliance With Harvard University 2UCB to Launch Research Alliance With Harvard University 3Verenium Announces Signing of Lease for New Office and Lab Space 2Verenium Announces Signing of Lease for New Office and Lab Space 3
...
Ultra-sensitive, non-radioactive detection of rat Osteopontin...
Agarose-LE, 250 g. Suitable for soft agarose cloning. Nuclease-free.Gel point (1.5%): 36 1.5 C, EEO (-mr): 1200 g/cm2. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Request Info...
Biology Products: