Navigation Links
Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons

Scientists have discovered that a stem cell factor overexpressed both in brain tumor cells and in neurons following brain injury promotes tumor survival by inducing angiogenesis. The research study, published in the April issue of Cancer Cell, examines the interaction between tumor cells and surrounding tissues and may have substantial significance for design of more effective therapeutics for one of the most lethal types of tumor, malignant gliomas.

Stem cell factor (SCF) is an important growth factor for multiple cell types. Research has shown that SCF is expressed in glioma cells and as a result of various types of brain injury, but its significance is not fully understood. Dr. Howard A. Fine from the National Cancer Institute/National Institute of Neurological Disorders and Stroke at the National Institutes of Health and colleagues designed a study to investigate whether, as a result of tumor-induced brain injury, brain cell-mediated SCF expression contributes to tumor growth by setting up an environment that supports angiogenesis and tumor progression.

The researchers demonstrate that decreased SCF expression in vivo results in decreased angiogenesis and improved survival in mouse glioma models, whereas overexpression of SCF is associated with a worse prognosis and shorter survival in patients with glioblastomas. SCF expression is not directly linked to tumor cell proliferation but instead encourages the growth of blood vessels needed to support the expanding tumor. Importantly, these findings provide definitive evidence that factors promoting tumor progression extend beyond the tumor itself and involve a complex interaction between the cancer cells and the normal cells that are perturbed by expanding tumor.

These results suggest that SCF is a potent glioma-associated angiogenic factor that plays a prominent role in pathological angiogenesis both through direct tumor cell expression of SCF and by normal neurons that are damaged by the gr owing tumor. The researchers point out that the clinical significance of these findings extends beyond identification of SCF as a rational target for gliomas. "Normal neuronal expression of SCF in response to traumatic brain injury also raises the disturbing possibility that standard invasive procedures such as surgical biopsies or partial tumor resections may be inducing a proangiogenic response, or trigger, within the brain," cautions Dr. Fine.


'"/>

Source:Cell Press


Related biology news :

1. Growth in the sea comes down to a struggle for iron
2. Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells
3. Growth in biomass could put US on road to energy independence
4. Embryonic Stem Cells Treated With Growth Factor Reverse Hemophilia In Mice: UNC Researchers
5. Missing Receptor Molecule Causes Tumor Growth
6. Growth hormone is made in the brain, report scientists
7. New Research Shows Artificial Light at Night Stimulates Breast Cancer Growth in Laboratory Mice
8. Growth factor stimulates rapid extension of key motor neurons in brain
9. Growth hormone to boost athletic performance risks diabetes
10. Growth hormone is not the anti-aging bullet for healthy adults
11. New lead reported in tumor angiogenesis
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/2/2016)... 2, 2016 The Department of Transport ... the 44 million US Dollar project, for the , ... including Personalization, Enrolment, and IT Infrastructure , to ... production and implementation of Identity Management Solutions. Numerous renowned international ... Decatur was selected for the most compliant ...
(Date:6/1/2016)... YORK , June 1, 2016 ... Technology in Election Administration and Criminal Identification to Boost ... to a recently released TechSci Research report, " Global ... By Region, Competition Forecast and Opportunities, 2011 - 2021", ... 24.8 billion by 2021, on account of growing security ...
(Date:5/16/2016)... May 16, 2016   EyeLock LLC , a ... the opening of an IoT Center of Excellence in ... expand the development of embedded iris biometric applications. ... of convenience and security with unmatched biometric accuracy, making ... aside from DNA. EyeLock,s platform uses video technology to ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Parallel 6 , the ... today the Clinical Reach Virtual Patient Encounter CONSULT module which enables both ... physician and clinical trial team. , Using the CONSULT module, patients and physicians can ...
(Date:6/27/2016)... -- Liquid Biotech USA , Inc. ... Research Agreement with The University of Pennsylvania ("PENN") ... patients.  The funding will be used to assess ... outcomes in cancer patients undergoing a variety of ... to support the design of a therapeutic, decision-making ...
(Date:6/24/2016)... 24, 2016 Epic Sciences unveiled a ... susceptible to PARP inhibitors by targeting homologous recombination ... The new test has already been incorporated into ... cancer types. Over 230 clinical trials ... pathways, including PARP, ATM, ATR, DNA-PK and WEE-1. ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, a leader in ... Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical research professionals, Mosio ... practical tips, tools, and strategies for clinical researchers. , “The landscape of how ...
Breaking Biology Technology: