Navigation Links
Group proves it's possible to grow new lung alveoli by growing new blood vessels

ng growth and ultimately lung function can be restored."

Doing that involved a new gene therapy technique, explains Dr. Thébaud. Knowing that a particular protein, VEGF, a vascular endothelial growth factor, is crucial for the normal development of the lung, and that angiopoeitin-1, another angiogenic growth factor is crucial for blood vessel maturation, the team attached the proteins to an adenovirus and administered it through an aerosol directly into the lungs. In effect, the virus carried the protein to the heart of millions of lung cells. Once inside the cells, the growth factor proteins went to work doing the job they were programmed to do.

The results were striking: In microscopic images, the scientists have charted the growth of alveoli and lung capillaries. In a typically healthy lung, a complex network of capillaries encircles the alveoli. Oxygen flows from the lungs through ultra-fine epithelial and endothelial tissues into the blood; carbon dioxide diffuses from the blood into the alveoli. In an infant's underdeveloped lungs, the alveoli are larger and fewer and there are fewer developed capillaries. It's a condition that leaves them gasping--and one that is shared by people who have emphysema.

"At this stage it's simply proof of principle," says Dr. Thébaud, also a pediatrician at the Stollery Children's Hospital's Neonatal Intensive Care Unit. The next step is to prove it's possible to replicate safely in larger mammals. Once that's done, it's possible the concept--growing blood vessels to cure a disease that is traditionally thought of as an airway disease--could be tested clinically in people.


'"/>

Source:University of Alberta


Page: 1 2

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. FDA Approves Human Hookworm Vaccine for Phase I Safety Trials
3. Purdue proves concept of using nano-materials for drug discovery
4. FDA Approves New Drug to Treat Type I and Type II Diabetes
5. Canada approves marijuana-based pain spray
6. Bevacizumab Combined With Chemotherapy Improves Progression-Free Survival for Patients With Advanced Breast Cancer
7. Product improves peptide identification for proteomics research
8. FDA Approves New Treatment for Chronic Hepatitis B
9. Stem cell treatment improves mobility after spinal cord injury
10. FDA approves more generic AIDS drugs
11. Experimental shingles vaccine proves effective in nationwide study
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Group proves possible grow new lung alveoli growing new blood vessels

(Date:4/16/2014)... you cannot lift your upper eyelid. You walk through life with ... they are rolled down in the eye socket. Obviously, such a ... their head. In order to correct this condition, one would need ... the April 16 print issue of the journal Neuron , ...
(Date:4/16/2014)... from the north-central U.S. and beyond will convene in ... science, expand on existing science, and explore the unique ... special emphasis on applied geology, paleontology, and mid-continent geology. ... Thursday by Dr. Kirk Johnson, Sant Director of the ...
(Date:4/16/2014)... , , Everything we do all of our movements, thoughts ... one another, and recent studies have suggested that some of ... known as astrocytes may be listening in on, or even ... study suggests that astrocytes might only be tuning in part ...
Breaking Biology News(10 mins):Researchers track down cause of eye mobility disorder 2Walking with mammoths and exploring mid-continental geology 2Walking with mammoths and exploring mid-continental geology 3Walking with mammoths and exploring mid-continental geology 4Eavesdropping on brain cell chatter 2Eavesdropping on brain cell chatter 3
... YORK , Dec. 3, 2013 Usernames and passwords ... public domains from unwarranted access. Yet, identity theft and corporate ... can be easily spoofed. Today, biometrics veteran Hector Hoyos ... aims to address and solve the issues of secure identity ...
... to the Arctic, as part of the Catlin Arctic Survey, ... just beneath the ocean surface are likely to battle for ... that copepods that move large distances, migrating vertically across a ... surviving. The increasing level of carbon dioxide in ...
... Arts and Sciences has developed a system of techniques ... a protected marine mammal habitat. The techniques are the ... Bulletin , focusing on the bottlenose dolphin population in ... in the Department of Biology, co-authored the article with ...
Cached Biology News:Hoyos Labs, a Digital Infrastructure Security Company, Launches; Rethinks How We Authenticate and Secure Identity 2Hoyos Labs, a Digital Infrastructure Security Company, Launches; Rethinks How We Authenticate and Secure Identity 3Arctic study shows key marine food web species at risk from increasing CO2 2SU biologist develops method for monitoring shipping noise in dolphin habitat 2
(Date:1/15/2014)... January 15, 2014 Look inside the ... items for the lab, from fluid handling to instruments ... to ship when you order. , Preferred Solutions ... , from the L/S® model for precise flow control ...
(Date:1/15/2014)... A study has been launched to test ... track could help to tackle the problem of obesity.  This ... GP surgery based in Stowmarket) and academics at University Campus ... Telemetry technology, which is inspired by equipment used to collect ...
(Date:1/15/2014)... 2013 was a banner year of continued innovation ... continued independent research led by the team at Wake ... million grant from the Susanne Marcus Collins Foundation, had ... reviewed journal, Amy Grant highlighted Brainwave Optimization® in First ...
(Date:1/14/2014)... 14, 2014 Carahsoft and CDS Federal ... 23, 2014 at 2pm EST (11am PST), “Natural Language ... focuses on how technology can turn raw, heterogeneous data ... government agencies. The online webinar will last approximately one ...
Breaking Biology Technology:Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2
... erect as many as five more buildings on its new ... well beyond its existing base of 2,500 employees, according to ... said the company anticipates adding 1,500 more individual offices, about ... addition, there remains plenty of room on the 380-acre Verona ...
... As we saw in the last article, 2006 was a good year ... We also saw that it was a mixed bag for the large-cap ... for these much more solid companies, then how was it for the ... look, the chart below is a reminder of the overall key market ...
... Wis. - A new $140 million biomedical research ... to executives of the Medical College of Wisconsin ... , ,With Gov. Jim Doyle and Milwaukee ... Medical College and the Children's Research Institute ...
Cached Biology Technology:Epic Systems will build well beyond current staff size 2A Midwest small-cap, life-science surprise package 2A Midwest small-cap, life-science surprise package 3A Midwest small-cap, life-science surprise package 4A Midwest small-cap, life-science surprise package 5Medical College dedicates $140M research facility 2
... HT is taking automated patch clamping to a ... ability to generate thousands of high quality data ... paradigms in ion channel drug discovery and safety ... quality afforded by conventional patch clamping can now ...
... mouse embryonic stem cells to dopaminergic neurons. ... where they are mainly located in the ... the retrorubral field. These dopaminergic (DA) neurons ... ( e.g.projections to the caudate nucleus, putamen ...
... RNA aptamer screening and binding optimization and ... microfluidic on-chip synthesis platform. Thousands of customer ... and LC Sciences can provide assistance with ... as part of our comprehensive DNA/RNA Aptamer ...
... synthetic peptide whose sequence is from the C-terminal end of the mouse ... from amino acids 429 to 448 of RAR*. The sequence of ... V - S - P - S - S - V - ... Q - S - P - L - L - Q ...
Biology Products: