Navigation Links
Group proves it's possible to grow new lung alveoli by growing new blood vessels

The good news is that medical advances in perinatal care have allowed us to save many more premature babies. The bad news is they're often at risk of developing bronchopulmonary dysplasia--a chronic lung disease caused by having to place the tiny infants on ventilators and oxygen-rich therapy for acute respiratory failure.

It's really a win-lose situation: the babies are saved but they pay the price with dramatically underdeveloped lungs--forcing them to spend their early days outside the womb fighting for every breath. And now, with many of these premature babies reaching their adolescent years, clinicians and researchers are also waiting to see whether longer term health problems are going to begin occurring.

"Right now we simply don't have any treatments," says Bernard Thébaud, a clinician-scientist and neonatologist in the Department of Pediatrics. "So, if we can't prevent it, we've started to think about how we might repair it."

Using animal models, Dr. Thébaud and a team of University of Alberta researchers have taken what they say is the first important step towards a treatment--in effect, growing new blood vessels and alveoli--the tiny air sacs where gas exchange occurs between the lungs and blood vessels--in tiny rat lungs.

The results of their work were recently published in Circulation, entitled Vascular Endothelial Growth Factor Gene Therapy Increases Survival, Promotes Lung Angiogenesis, and Prevents Alveolar Damage in Hyperoxia-Induced Lung Injury: Evidence That Angiogenesis Participates in Alveolarization.

The results have caused a stir in the scientific community: In an accompanying editorial in the October 18 issue of the journal, Kurt Stenmark, a University of Colorado Divisions of Critical Care and Pulmonary Medicine researcher, said the studies "…raise new possibilities for the treatment of infants with severe chronic lung disease. It seems possible that by augmenting or restoring vascular growth, overall lu ng growth and ultimately lung function can be restored."

Doing that involved a new gene therapy technique, explains Dr. Thébaud. Knowing that a particular protein, VEGF, a vascular endothelial growth factor, is crucial for the normal development of the lung, and that angiopoeitin-1, another angiogenic growth factor is crucial for blood vessel maturation, the team attached the proteins to an adenovirus and administered it through an aerosol directly into the lungs. In effect, the virus carried the protein to the heart of millions of lung cells. Once inside the cells, the growth factor proteins went to work doing the job they were programmed to do.

The results were striking: In microscopic images, the scientists have charted the growth of alveoli and lung capillaries. In a typically healthy lung, a complex network of capillaries encircles the alveoli. Oxygen flows from the lungs through ultra-fine epithelial and endothelial tissues into the blood; carbon dioxide diffuses from the blood into the alveoli. In an infant's underdeveloped lungs, the alveoli are larger and fewer and there are fewer developed capillaries. It's a condition that leaves them gasping--and one that is shared by people who have emphysema.

"At this stage it's simply proof of principle," says Dr. Thébaud, also a pediatrician at the Stollery Children's Hospital's Neonatal Intensive Care Unit. The next step is to prove it's possible to replicate safely in larger mammals. Once that's done, it's possible the concept--growing blood vessels to cure a disease that is traditionally thought of as an airway disease--could be tested clinically in people.


'"/>

Source:University of Alberta


Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. FDA Approves Human Hookworm Vaccine for Phase I Safety Trials
3. Purdue proves concept of using nano-materials for drug discovery
4. FDA Approves New Drug to Treat Type I and Type II Diabetes
5. Canada approves marijuana-based pain spray
6. Bevacizumab Combined With Chemotherapy Improves Progression-Free Survival for Patients With Advanced Breast Cancer
7. Product improves peptide identification for proteomics research
8. FDA Approves New Treatment for Chronic Hepatitis B
9. Stem cell treatment improves mobility after spinal cord injury
10. FDA approves more generic AIDS drugs
11. Experimental shingles vaccine proves effective in nationwide study
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/18/2016)... 18, 2016 --> ... ICT, Manned & Unmanned Vehicles, Physical infrastructure and Perimeter Surveillance ... in the border security market and the continuing migration crisis ... Europe has led visiongain to publish this ... --> defence & security companies in the ...
(Date:3/14/2016)... , Allemagne, March 14, 2016 ... http://www.apimages.com ) - --> - Renvoi : ... - --> --> ... solutions biométriques, fournit de nouveaux lecteurs d,empreintes digitales ... LF10 de DERMALOG sera utilisé pour produire des ...
(Date:3/9/2016)... YORK , March 9, 2016 This ... and future states of the RNA Sequencing (RNA Seq) ... segments such as instruments, tools and reagents, data analysis, ... Analyze various segments of the RNA-Sequencing market such as ... services Identify the main factors affecting each segment and ...
Breaking Biology News(10 mins):
(Date:5/6/2016)... , May 6, 2016 According to ... Molecular Diagnostic Market for Group A Streptococcus (GAS) Nucleic Acid ... Growth, Trends, and Forecast, 2015 - 2023 ", the ... streptococcus (GAS) nucleic acid (NA) test products market was valued ... expand at a CAGR of 11.6% from 2015 to 2023 ...
(Date:5/5/2016)... ... 05, 2016 , ... American Process, Inc. (API) announced that ... Nos. 9,322,133 and 9,322,134, to API and its affiliated companies for BioPlus® nanocellulose ... nanocellulose compositions. In addition to these patents and U.S. Patent No. 9,187,865 ...
(Date:5/4/2016)... (PRWEB) , ... May 04, 2016 , ... Proove ... to announce a strategic partnership with McGill University . The partnership is designed ... the market in order to help patients in pain. With the new agreement, researchers ...
(Date:5/4/2016)... ... May 04, 2016 , ... ... in biotechnology to help treat hormonal and stress related hair loss. With patent-pending ... the hearts of key opinion leaders in the medical and salon channels nationwide. ...
Breaking Biology Technology: